| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B E Sumner, K E Grant, R Rosie, C Hegele-Hartung, K H Fritzemeier, G Fin. Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine(2A) receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581405. |
estradiol-17beta (e(2)), in its positive feedback mode for gonadotropin release in the female rat, induces expression of the genes for the 5-hydroxytryptamine(2a) receptor (5-ht(2a)r) and the serotonin transporter (sert) in the dorsal raphe nucleus (drn) with a concomitant increase in the densities of 5-ht(2a)r and the sert in rat forebrain. |
2000-02-14 |
2023-08-12 |
rat |
| B E Sumner, K E Grant, R Rosie, C Hegele-Hartung, K H Fritzemeier, G Fin. Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine(2A) receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581405. |
acute treatment ( approximately 32 h) of ovariectomized rats with estradiol benzoate (eb) increased significantly the amount of 5-ht(2a)r mrna and sert mrna in the drn and the densities of 5-ht(2a)r and sert binding sites in the forebrain. |
2000-02-14 |
2023-08-12 |
rat |
| Y Smicun, S D Campbell, M A Chen, H Gu, G Rudnic. The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593887. |
chimeric transporters were constructed in which the predicted external loops of the serotonin transporter (sert) were replaced one at a time with a corresponding sequence from the norepinephrine transporter (net). |
2000-01-27 |
2023-08-12 |
Not clear |
| Y Smicun, S D Campbell, M A Chen, H Gu, G Rudnic. The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593887. |
chimeric transporters did not gain affinity for dopamine, a net substrate, or desipramine, an inhibitor, at the expense of affinity for serotonin or paroxetine, a selective sert inhibitor. |
2000-01-27 |
2023-08-12 |
Not clear |
| B G Condro. Serotonergic neurons transiently require a midline-derived FGF signal. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595507. |
in the grasshopper cns, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or sert. |
2000-01-04 |
2023-08-12 |
Not clear |
| O V Mortensen, A S Kristensen, G Rudnick, O Wibor. Molecular cloning, expression and characterization of a bovine serotonin transporter. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407194. |
the serotonin transporter (sert) is a member of a highly homologous family of sodium/chloride dependent neurotransmitter transporters responsible for reuptake of biogenic amines from the extracellular fluid. |
1999-12-22 |
2023-08-12 |
human |
| A R Belous, S Rammamoorthy, R D Blakely, M I Factor, A M Dupin, A B Katasonov, R Kh Lozier, A G Beniashvili, M A Morozova, O S Bruso. [The status of serotonin protein -- a serotonin transporter in thrombocytes in patients with somatoform disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 99. issue 11. 1999-12-21. PMID:10578533. |
the role of serotonin transporter (sert) protein in the development of somatoform disorders (sd) was investigated. |
1999-12-21 |
2023-08-12 |
Not clear |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
to investigate functional changes in the brain serotonin transporter (sert) after chronic antidepressant treatment, several techniques were used to assess sert activity, density, or its mrna content. |
1999-12-17 |
2023-08-12 |
rat |
| S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Fraze. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575045. |
the serotonin content of the hippocampus was unaffected by paroxetine or sertraline treatment, ruling out neurotoxicity as a possible explanation for the ssri-induced decrease in sert binding and alteration in 5-ht clearance. |
1999-12-17 |
2023-08-12 |
rat |
| G Fink, B Sumner, R Rosie, H Wilson, J McQuee. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behavioural brain research. vol 105. issue 1. 1999-12-10. PMID:10553690. |
our previous experimental findings in female rats suggest that these effects may be mediated, in part, by the action of estrogen on the 5-hydroxytryptamine2a receptor (5-ht(2a)r) and serotonin transporter (sert) in brain. |
1999-12-10 |
2023-08-12 |
human |
| G Fink, B Sumner, R Rosie, H Wilson, J McQuee. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behavioural brain research. vol 105. issue 1. 1999-12-10. PMID:10553690. |
here we review our recent findings on the effect of acute (approximately 32 h) testosterone manipulation on central 5-ht(2a)r and sert in male rats. |
1999-12-10 |
2023-08-12 |
human |
| G Fink, B Sumner, R Rosie, H Wilson, J McQuee. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behavioural brain research. vol 105. issue 1. 1999-12-10. PMID:10553690. |
castration decreased while testosterone or estrogen, but not 5alpha-dihydrotestosterone (5alpha-dht), increased significantly the content of 5-ht(2a)r mrna and sert mrna in the dorsal raphe nucleus (dr) and the density of 5-ht(2a)r and sert binding sites in higher centers of the brain. |
1999-12-10 |
2023-08-12 |
human |
| G Fink, B Sumner, R Rosie, H Wilson, J McQuee. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behavioural brain research. vol 105. issue 1. 1999-12-10. PMID:10553690. |
the estrogen induction of sert mrna is most prominent in the rostral dr and this together with the correlation between sensitivity of dr serotonin neurons to estrogen and neurotoxic amphetamine derivatives provides a potential topochemical handle with which to investigate testosterone/estrogen regulation of sert gene expression. |
1999-12-10 |
2023-08-12 |
human |
| A Bocchetta, M P Piccardi, M A Palmas, C Chillotti, A Oi, M Del Zomp. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490710. |
polymorphism at dopamine receptor genes drd2, drd4, and dopamine and serotonin transporter genes (dat, sert) has been used in previous association studies. |
1999-11-17 |
2023-08-12 |
Not clear |
| A Vicentic, G Battaglia, F I Carroll, M J Kuha. Serotonin transporter production and degradation rates: studies with RTI-76. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546982. |
the objective of this study was to examine the turnover of the serotonin transporter (sert) by determining its production rate (r), degradation rate constant (k) and half-life of recovery (t1/2). |
1999-11-17 |
2023-08-12 |
rat |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
in this study, the hypothesis was partially investigated by determining the potencies of haloperidol and reduced haloperidol and the corresponding pyridinium and tetrahydropyridine metabolites, compared with mpp+ and mptp, as inhibitors of the noradrenaline transporter (nat), dopamine transporter (dat) and 5-ht transporter (sert). |
1999-11-08 |
2023-08-12 |
human |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
two days after cos-7 cells were transiently transfected with the cdna for the human nat, dat or sert (lipofectamine method), the cells were incubated with 10 nm [3h]noradrenaline, dopamine or 5-ht, respectively, for 2 min at 37 c, in the absence or presence of various concentrations of the eight compounds or a specific uptake inhibitor (nat: nisoxetine 1 microm; dat: gbr 12909 1 microm; sert: citalopram 10 microm). |
1999-11-08 |
2023-08-12 |
human |
| M J Kuhar, K M McGirr, R G Hunter, P D Lambert, B E Garrett, F I Carrol. Studies of selected phenyltropanes at monoamine transporters. Drug and alcohol dependence. vol 56. issue 1. 1999-10-12. PMID:10462087. |
in this study, 18 3-phenyltropane analogues were characterized in uptake and binding studies at dopamine (dat), norepinephrine (net) and serotonin (sert) transporters from the rat, and in binding at dat in rat, rhesus monkey, and human brain tissue. |
1999-10-12 |
2023-08-12 |
human |
| M P Kung, C Hou, S Oya, M Mu, P D Acton, H F Kun. Characterization of [(123)I]IDAM as a novel single-photon emission tomography tracer for serotonin transporters. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436197. |
development of selective serotonin transporter (sert) tracers for single-photon emission tomography (spet) is important for studying the underlying pharmacology and interaction of specific serotonin reuptake site inhibitors, commonly used antidepressants, at the sert sites in the human brain. |
1999-10-07 |
2023-08-12 |
human |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
the 5-ht levels reflect vesicular release and plasmalemmal reuptake through the serotonin transporter (sert). |
1999-09-23 |
2023-08-12 |
rat |