| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Inazu, H Takeda, H Ikoshi, M Sugisawa, Y Uchida, T Matsumiy. Pharmacological characterization and visualization of the glial serotonin transporter. Neurochemistry international. vol 39. issue 1. 2001-08-02. PMID:11311448. |
glial serotonin transporter (sert) plays an important role in the re-uptake of 5-hydroxytryptamine (5-ht). |
2001-08-02 |
2023-08-12 |
rat |
| M Inazu, H Takeda, H Ikoshi, M Sugisawa, Y Uchida, T Matsumiy. Pharmacological characterization and visualization of the glial serotonin transporter. Neurochemistry international. vol 39. issue 1. 2001-08-02. PMID:11311448. |
we examined the pharmacological characterization of 5-ht uptake into rat cortical synaptosomes and cultured rat astrocytes, and the immunodetection of glial sert proteins using specific site-directed monoclonal antibodies (moab). |
2001-08-02 |
2023-08-12 |
rat |
| N Kubota, Y Kiuchi, M Nemoto, H Oyamada, M Ohno, H Funahashi, S Shioda, K Oguch. Regulation of serotonin transporter gene expression in human glial cells by growth factors. European journal of pharmacology. vol 417. issue 1-2. 2001-07-19. PMID:11301061. |
the cdna sequence of the "glial" serotonin transporter in astrocytes was consistent with that reported for the "neuronal" serotonin transporter (sert). |
2001-07-19 |
2023-08-12 |
human |
| S G Rasmussen, F I Carroll, M J Maresch, A D Jensen, C G Tate, U Gethe. Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11062247. |
to explore the biophysical properties of the binding site for cocaine and related compounds in the serotonin transporter sert, a high affinity cocaine analogue (3beta-(4-methylphenyl)tropane-2beta-carboxylic acid n-(n-methyl-n-(4-nitrobenzo-2-oxa-1,3-diazol-7-yl)ethanolamine ester hydrochloride (rti-233); k(i) = 14 nm) that contained the environmentally sensitive fluorescent moiety 7-nitrobenzo-2-oxa-1,3-diazole (nbd) was synthesized. |
2001-06-28 |
2023-08-12 |
rat |
| K Muneoka, T Ogawa, K Kamei, Y Mimura, H Kato, M Takigaw. Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain. European journal of pharmacology. vol 411. issue 3. 2001-06-21. PMID:11164385. |
we examined the effects of nicotine exposure during pregnancy on serotonin transporter (sert) expression in the brain. |
2001-06-21 |
2023-08-12 |
rat |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
recent studies reveal that dopamine (da), norepinephrine (ne), and serotonin (5-ht) transporters (dat, net, and sert, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase c (pkc). |
2001-06-07 |
2023-08-12 |
human |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
phorbol esters, which trigger sert phosphorylation, also diminish sert/pp2ac associations, effects that can be blocked by pkc antagonists as well as the sert substrate 5-ht. |
2001-06-07 |
2023-08-12 |
human |
| A P Tamiz, B C Bandyopadhyay, J Zhang, J L Flippen-Anderson, M Zhang, C Z Wang, K M Johnson, S Tella, A P Kozikowsk. Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. Journal of medicinal chemistry. vol 44. issue 10. 2001-06-07. PMID:11334571. |
in this series, the bivalent ligand 16, comprised of two (+)-trans-piperidine units linked by a pentamethylene spacer, exhibits a combination of high da transporter (dat) and 5-ht transporter (sert) activity (k(i) = 39 nm and 7 nm, respectively). |
2001-06-07 |
2023-08-12 |
mouse |
| S Houle, N Ginovart, D Hussey, J H Meyer, A A Wilso. Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB. European journal of nuclear medicine. vol 27. issue 11. 2001-05-31. PMID:11105830. |
two novel radioligands, n,n-dimethyl-2-(2-amino-4-methoxyphenylthio) b enzylamine (dapp) and (n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine (d asb), were radiolabeled with carbon-11 and evaluated as in vivo probes of the serotonin transporter (sert) using positron emission tomography (pet). |
2001-05-31 |
2023-08-12 |
human |
| S Houle, N Ginovart, D Hussey, J H Meyer, A A Wilso. Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB. European journal of nuclear medicine. vol 27. issue 11. 2001-05-31. PMID:11105830. |
inhibition of specific binding to the sert was demonstrated in three additional subjects imaged with [11c]dasb following an oral dose of the selective serotonin reuptake blocker citalopram. |
2001-05-31 |
2023-08-12 |
human |
| D C Mash, J K Staley, S Izenwasser, M Basile, A J Ruttenbe. Serotonin transporters upregulate with chronic cocaine use. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207425. |
we have examined the status of the 5-ht transporter (sert) using ligand binding and autoradiographic methods in subgroups of cocaine overdose deaths. |
2001-05-24 |
2023-08-12 |
human |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (dat), serotonin (sert), and norepinephrine (net). |
2001-05-21 |
2023-08-12 |
mouse |
| A K Dutta, X S Fei, P M Beardsley, J L Newman, M E Reit. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. Journal of medicinal chemistry. vol 44. issue 6. 2001-05-03. PMID:11300876. |
novel analogues were tested for potency in inhibiting [3h]win 35,428, [3h]citalopram, and [3h]nisoxetine binding at the dat, serotonin transporter (sert), and norepinepherine transporter (net). |
2001-05-03 |
2023-08-12 |
mouse |
| A K Dutta, M E Reith, B K Madra. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180505. |
the compound 1b was characterized for its binding both in monkey and rat striatum tissue, which demonstrated its high selectivity for the dopamine transporter (dat) when its binding was compared with that at the serotonin transporter (sert). |
2001-04-19 |
2023-08-12 |
rat |
| A K Dutta, X S Fei, R A Vaughan, J D Gaffaney, N Wang, J R Lever, M E Reit. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life sciences. vol 68. issue 16. 2001-04-19. PMID:11292062. |
gbr 12909 when their selectivity was compared with the serotonin transporter (sert). |
2001-04-19 |
2023-08-12 |
Not clear |
| V Faivre, V Rosilio, P Manivet, D Langevin, J M Launay, A Baszki. Molecular organization of the human serotonin transporter at the air/water interface. FEBS letters. vol 492. issue 1-2. 2001-04-12. PMID:11248229. |
the serotonin transporter (sert) is the target of several important antidepressant and psychostimulant drugs. |
2001-04-12 |
2023-08-12 |
human |
| E M Adkins, E L Barker, R D Blakel. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular pharmacology. vol 59. issue 3. 2001-03-22. PMID:11179447. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) is responsible for the inactivation of synaptic 5-ht and is also a target for multiple psychostimulants. |
2001-03-22 |
2023-08-12 |
human |
| E M Adkins, E L Barker, R D Blakel. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular pharmacology. vol 59. issue 3. 2001-03-22. PMID:11179447. |
despite the critical role of sert in 5-ht inactivation and psychostimulant response, many aspects of the transporter's recognition of ligands are poorly defined. |
2001-03-22 |
2023-08-12 |
human |
| E M Adkins, E L Barker, R D Blakel. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular pharmacology. vol 59. issue 3. 2001-03-22. PMID:11179447. |
tryptamine derivatives with substitutions at the 4 and 7 positions on the phenyl ring, the indole nitrogen, and the beta position show up to 40-fold potency differences for inhibiting [(3)h]5-ht transport in cells transfected with either human or drosophila melanogaster sert cdnas. |
2001-03-22 |
2023-08-12 |
human |
| R A Lea, A Dohy, K Jordan, S Quinlan, P J Brimage, L R Griffith. Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine. Neurogenetics. vol 3. issue 1. 2001-02-22. PMID:11085595. |
polymorphisms within the dopamine beta-hydroxylase (dbh) gene, serotonin transporter gene (sert), and dopamine receptor gene (drd2) were tested in 177 unrelated caucasian migraineurs and 182 control individuals. |
2001-02-22 |
2023-08-12 |
Not clear |