| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cynthia L Bethea, Stephanie J Mirkes, Annetta Su, David Michelso. Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques. Psychoneuroendocrinology. vol 27. issue 4. 2002-06-28. PMID:11911997. |
we previously showed that estrogen (e) treatment of female macaques via silastic implant alters gene expression for tryptophan hydroxylase (tph), the serotonin reuptake transporter (sert) and the 5ht1a autoreceptor. |
2002-06-28 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Stephanie J Mirkes, Annetta Su, David Michelso. Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques. Psychoneuroendocrinology. vol 27. issue 4. 2002-06-28. PMID:11911997. |
in conclusion, the selective estrogen receptor modulators, raloxifene and arzoxifene, act in a manner similar to natural e on tph and sert mrna expression in serotonin neurons. |
2002-06-28 |
2023-08-12 |
Not clear |
| I Scott Ramsey, Louis J DeFelic. Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor. The Journal of biological chemistry. vol 277. issue 17. 2002-05-31. PMID:11844791. |
we postulate that sert interacts allosterically with an endogenous factor of limited abundance to alter substrate and inhibitor potency and the balance of 5-ht transport and channel-like activity. |
2002-05-31 |
2023-08-12 |
xenopus_laevis |
| Evgeny A Budygin, Carrie E John, Yolanda Mateo, Sara R Jone. Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 10. 2002-05-29. PMID:12006604. |
additionally, fluoxetine, a serotonin transporter (sert) inhibitor, also had no effect on these parameters. |
2002-05-29 |
2023-08-12 |
mouse |
| Maxim L Filipenko, Alexandra G Beilina, Olga V Alekseyenko, Vadim V Dolgov, Natalia N Kudryavtsev. Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice. Neuroscience letters. vol 321. issue 1-2. 2002-05-23. PMID:11872248. |
serotonin transporter (sert) and monoamine oxidase a (maoa) mrna levels in the raphe nuclei area of the midbrain were measured by the multiplex reverse transcription-polymerase chain reaction method in male mice with repeated experience of social victories (winners) and defeats (losers) in ten daily agonistic confrontations. |
2002-05-23 |
2023-08-12 |
mouse |
| Maxim L Filipenko, Alexandra G Beilina, Olga V Alekseyenko, Vadim V Dolgov, Natalia N Kudryavtsev. Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice. Neuroscience letters. vol 321. issue 1-2. 2002-05-23. PMID:11872248. |
it has been supposed that sert and maoa genes are involved in enhancement of serotonin inactivation in response to the increase of serotonergic activity shown earlier in the losers. |
2002-05-23 |
2023-08-12 |
mouse |
| Zsolt Szabo, Una D McCann, Alan A Wilson, Ursula Scheffel, Taofeek Owonikoko, William B Mathews, Hayden T Ravert, John Hilton, Robert F Dannals, George A Ricaurt. Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 43. issue 5. 2002-05-23. PMID:11994534. |
there has been considerable interest in the development of a pet radioligand selective for the serotonin (5-hydroxytryptamine [5-ht]) transporter (sert) that can be used to image 5-ht neurons in the living human brain. |
2002-05-23 |
2023-08-12 |
human |
| R Weitzdoerfer, N Gerstl, H Hoeger, W Mosgoeller, W Dreher, E Engidawork, J Overgaard-Larsen, B Lube. Long-term sequelae of perinatal asphyxia in the aging rat. Cellular and molecular life sciences : CMLS. vol 59. issue 3. 2002-05-16. PMID:11964129. |
increased serotonin transporter (sert) immunoreactivity in the ca2 region of the hippocampus and a significant difference in the escape latency, when the platform of the mwm was moved to a new location, were observed in asphyxiated rats. |
2002-05-16 |
2023-08-12 |
human |
| Richard B Rothman, F Ivy Carroll, Marisela Morales, Daniel L Rowley, Kenner C Rice, Christina M Dersch, David M Donova. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). vol 44. issue 2. 2002-05-13. PMID:11891881. |
binding surface analysis of [(125)i]rti-55 binding to membranes prepared from the brains of wt mice, with 100 nm citalopram to block binding to the 5-ht transporter (sert), revealed two binding sites: the dat and a second site, replicating previous studies conducted with rat brains. |
2002-05-13 |
2023-08-12 |
mouse |
| Ao Zhang, Guochun Zhou, Alexander Hoepping, Jayanta Mukhopadhyaya, Kenneth M Johnson, Mei Zhang, Alan P Kozikowsk. Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. Journal of medicinal chemistry. vol 45. issue 9. 2002-05-10. PMID:11960503. |
most compounds in this series possessed a very low activity at the da transporter (dat) but a good to excellent affinity for the 5-ht transporter (sert). |
2002-05-10 |
2023-08-12 |
rat |
| Paolo Benedetti, Raimund Mannhold, Gabriele Cruciani, Manuel Pasto. GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931612. |
the aim of the study is to gain insight into the structural requirements that determine the affinity of the data set molecules to the dat and the serotonin transporter (sert) as well as their inhibitory potency on dopamine uptake. |
2002-05-06 |
2023-08-12 |
Not clear |
| Patrick Emond, Johnny Vercouillie, Robert Innis, Sylvie Chalon, Sylvie Mavel, Yves Frangin, Christer Halldin, Jean-Claude Besnard, Denis Guillotea. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881994. |
a series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (sert), and norepinephrine transporters. |
2002-04-26 |
2023-08-12 |
Not clear |
| Ling-Wei Hsin, Christina M Dersch, Michael H Baumann, David Stafford, John R Glowa, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11882001. |
the s enantiomers displayed higher dopamine transporter (dat) affinity and the r enantiomers were found to interact at the serotonin transporter (sert) with higher affinity. |
2002-04-26 |
2023-08-12 |
monkey |
| D Martinez, A Broft, M Laruell. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. vol 2. issue 3. 2002-04-18. PMID:11535111. |
this paper reviews brain imaging studies designed to evaluate the significance of polymorphisms in genes coding for important drug targets (e.g., the serotonin transporter [sert], the dopamine transporter [dat] and the dopamine d(2) receptor) in terms of expression or function. |
2002-04-18 |
2023-08-12 |
human |
| Ming Li, Robert A Farley, Henry A Leste. Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel ligands. FEBS letters. vol 513. issue 2-3. 2002-04-16. PMID:11904159. |
voltage-dependent transient currents of human and rat 5-ht transporters (sert) are blocked by hepes and ion channel ligands. |
2002-04-16 |
2023-08-12 |
human |
| Ming Li, Robert A Farley, Henry A Leste. Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel ligands. FEBS letters. vol 513. issue 2-3. 2002-04-16. PMID:11904159. |
the hyperpolarization-activated transient current of mammalian 5-hydroxytryptamine transporters (sert) expressed in xenopus oocytes was studied. |
2002-04-16 |
2023-08-12 |
human |
| Wenxia Zhou, Nina Koldzic-Zivanovic, Charlotte H Clarke, René de Beun, Karsten Wassermann, Paul S Bury, Kathryn A Cunningham, Mary L Thoma. Selective estrogen receptor modulator effects in the rat brain. Neuroendocrinology. vol 75. issue 1. 2002-03-26. PMID:11810032. |
based upon the hypothesis that serotonin (5-ht)-steroid hormone interactions are important in mood regulation, we have compared six serms (tamoxifen, raloxifene, levormeloxifene, nnc 45-0781, nnc 45-0320, nnc 45-1506) with 17beta-estradiol (e(2)) in terms of their ability to regulate mrna levels of estrogen receptor (er)alpha, er beta, 5-ht(1a) receptor, and 5-ht reuptake transporter (sert) in the midbrain, amygdala, and hypothalamus of ovariectomized (ovx) rats. |
2002-03-26 |
2023-08-12 |
rat |
| O S Brusov, M I Faktor, G P Zlobina, P V Bologov, V G Kaleda, I V Oleĭchik, A N Korenev, A N Piatnitskiĭ, A M Dupin, A B Katasonov, M A Morozova, A G Beniashvili, R Kh Lozier, E V Pavlova, O L Segal, Iu S Massino, A D Dmitrie. [Levels and molecular heterogeneity of serotonin transporter protein in platelets of patients with different mental diseases: a comparative analysis with the use of monoclonal and polyclonal antibodies]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 7. 2002-03-18. PMID:11523428. |
polyclonal (pab) and monoclonal (mab) antibodies to ct2-epitope of the c-terminal fragment of serotonin transporter (sert) protein were used to study the levels and molecular heterogeneity of platelet sert in healthy donors and patients with affective (ad) and somatoform (sd) disorders, schizoaffective disorder (sad) and schizophrenia. |
2002-03-18 |
2023-08-12 |
Not clear |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| J Haase, A M Killian, F Magnani, C William. Regulation of the serotonin transporter by interacting proteins. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709063. |
the serotonin transporter (sert) plays a critical role in the maintenance of normal neurotransmission by serotonin [5-hydroxytryptamine (5-ht)]. |
2002-03-12 |
2023-08-12 |
rat |