| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher G Tate, Jana Haase, Cara Baker, Marco Boorsma, Francesca Magnani, Yvonne Vallis, D Clive William. Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. Biochimica et biophysica acta. vol 1610. issue 1. 2003-06-03. PMID:12586388. |
all the mammalian cell lines expressed functional sert, but sert expressed in e. coli or p. pastoris was nonfunctional as assessed by 5-hydroxytryptamine uptake and inhibitor binding assays. |
2003-06-03 |
2023-08-12 |
rat |
| David C Purselle, Charles B Nemerof. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655305. |
these findings, taken together, suggest that alterations in the serotonergic system might contribute to suicidal behavior, serving as an impetus for researchers to scrutinize the serotonin transporter (sert) as a potential substrate for the pathophysiology of suicide. |
2003-05-29 |
2023-08-12 |
Not clear |
| Paul A T Kelly, Isobel M Ritchie, Linda Quate, Douglas E McBean, Henry J Olverma. Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain. British journal of pharmacology. vol 137. issue 7. 2003-05-20. PMID:12429568. |
in this study we have examined methylenedioxymethamphetamine (mdma)-induced toxicity in perinatal rat brain, related this to normal development of serotonin transporter sites (sert), and determined whether early exposure to mdma subsequently alters cerebral function in adults. |
2003-05-20 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Zhihong Zhu, Sung-A Bae, Ningning Guo, Yasuhiko Sudo, Lawrence S Kegeles, Marc Laruell. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). Nuclear medicine and biology. vol 29. issue 7. 2003-05-19. PMID:12381454. |
a new pet radioligand for the serotonin transporter (sert), [11c]-5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11c]dapa (10), was synthesized and evaluated in vivo in rats and baboons. |
2003-05-19 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Zhihong Zhu, Sung-A Bae, Ningning Guo, Yasuhiko Sudo, Lawrence S Kegeles, Marc Laruell. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). Nuclear medicine and biology. vol 29. issue 7. 2003-05-19. PMID:12381454. |
moreover, such binding in sert-rich regions of the brain are blocked by pretreatment with either the selective serotonin reuptake inhibitor (ssri) citalopram and by the cold compound itself, demonstrating that [11c]dapa binding in the rat brain is saturable and specific to sert. |
2003-05-19 |
2023-08-12 |
rat |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| Carles Gil, Abderrahim Najib, José Aguiler. Serotonin transport is modulated differently by tetanus toxin and growth factors. Neurochemistry international. vol 42. issue 7. 2003-05-01. PMID:12590935. |
in spite of this, growth factors and tetx show an opposite effect on 5-ht transport, even though sert phosphorylation is enhanced in both cases. |
2003-05-01 |
2023-08-12 |
Not clear |
| J P Wisor, S W Wurts, F S Hall, K P Lesch, D L Murphy, G R Uhl, D M Edga. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport. vol 14. issue 2. 2003-04-30. PMID:12598736. |
the monoamine neurotransmitter serotonin has long been implicated in development and maintenance of sleep patterns, yet the role of the serotonin transporter (sert) in these processes has not been evaluated in detail. |
2003-04-30 |
2023-08-12 |
mouse |
| J P Wisor, S W Wurts, F S Hall, K P Lesch, D L Murphy, G R Uhl, D M Edga. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport. vol 14. issue 2. 2003-04-30. PMID:12598736. |
genetic differences in serotonin systems and developmental exposure to sert blockers are likely to exert effects on rems. |
2003-04-30 |
2023-08-12 |
mouse |
| Justine M Kent, Jeremy D Coplan, Ilise Lombardo, Dah-Ren Hwang, Yiyun Huang, Osama Mawlawi, Ronald L Van Heertum, Mark Slifstein, Anissa Abi-Dargham, Jack M Gorman, Marc Laruell. Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457263. |
although selective serotonin reuptake inhibitors (ssris) are widely used in the treatment of anxiety and depressive disorders, the occupancy of the serotonin reuptake transporter (sert) achieved in humans at typical clinical doses by these agents remains poorly characterized. |
2003-04-23 |
2023-08-12 |
Not clear |
| G Berding, Th Brücke, P Odin, D J Brooks, H Kolbe, P Gielow, H Harke, B O Knoop, R Dengler, W H Knap. [[123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin. Nuclear medicine. vol 42. issue 1. 2003-04-17. PMID:12601452. |
definition of the regional pattern of dopamine transporter (dat) dysfunction in advanced parkinson's disease (pd) and evaluation of a potential correlation between dat binding and symptoms; elucidation of the role of dat imaging in the differential diagnosis of pd and multiple system atrophy (msa); assessment and comparison of serotonin transporter (sert) binding in pd and msa. |
2003-04-17 |
2023-08-12 |
Not clear |
| Ralph Buchert, Rainer Thomasius, Bruno Nebeling, Kay Petersen, Jost Obrocki, Lars Jenicke, Florian Wilke, Lutz Wartberg, Pavlina Zapletalova, Malte Clause. Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 3. 2003-04-11. PMID:12621003. |
to address this question, pet was performed using the serotonin transporter (sert) ligand (11)c-(+)-mcn5652 in a total of 117 subjects subdivided into 4 groups: actual ecstasy users (n = 30), former ecstasy users (n = 29), drug-naive control subjects (n = 29), and subjects with abuse of psychoactive agents other than ecstasy (n = 29). |
2003-04-11 |
2023-08-12 |
human |
| Edgardo Vega, Maria Isolde Rudolp. Characterization of oxytocin receptors and serotonin transporters in mast cells. Endocrine. vol 18. issue 2. 2003-04-07. PMID:12374464. |
this also predicts the presence of oxytocin receptors (otrs) and transducing signals that will interact with 5ht transporters (sert) in mast cells. |
2003-04-07 |
2023-08-12 |
Not clear |
| Edgardo Vega, Maria Isolde Rudolp. Characterization of oxytocin receptors and serotonin transporters in mast cells. Endocrine. vol 18. issue 2. 2003-04-07. PMID:12374464. |
the signaling between the otr and the sert was analyzed by measuring the extent of inhibition of ot and pma (activator of protein kinase c on 5ht uptake and the capability of ro318220 (specific inhibitor of pkc) to increase 5ht uptake and block the effect of the above compounds in mast cells. |
2003-04-07 |
2023-08-12 |
Not clear |
| Edgardo Vega, Maria Isolde Rudolp. Characterization of oxytocin receptors and serotonin transporters in mast cells. Endocrine. vol 18. issue 2. 2003-04-07. PMID:12374464. |
the results showed that in murine peritoneal mast cells in vitro (1) ovarian hormones modulate otr but not sert expression, (2) the magnitude of ot action on 5ht uptake depends on the number of otrs expressed in mast cells, and (3) the signaling between otr and the sert is mediated through the activation of protein kinase c. it is concluded that the ovarian hormones have a modulatory action on 5ht uptake which involves ot-mediated mechanism. |
2003-04-07 |
2023-08-12 |
Not clear |
| Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemerof. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry. vol 46. issue 6. 2003-04-07. PMID:12620070. |
2beta-carbomethoxy-3beta-(4'-((z)-2-iodoethenyl)phenyl)nortropane (zient) (6) and 2beta-carbomethoxy-3beta-(4'-((e)-2-iodoethenyl)phenyl)nortropane (eient) (10) were prepared and evaluated in vitro and in vivo for serotonin transporter (sert) selectivity and specificity. |
2003-04-07 |
2023-08-12 |
human |
| Peter S Talbot, Marc Laruell. The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 6. 2003-03-25. PMID:12468013. |
for ssris, high occupancies at the serotonin transporter (sert) are achieved at therapeutic doses, although the minimum sert occupancy required for therapeutic response remains undefined. |
2003-03-25 |
2023-08-12 |
human |
| Julia Wellsow, Karl-Artur Kovar, Hans-Jürgen Machull. Molecular modeling of potential new and selective PET radiotracers for the serotonin transporter. Positron Emission Tomography. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 5. issue 3. 2003-03-17. PMID:12553893. |
imaging the serotonin transporter (sert) with positron emission tomography (pet) provides a useful tool for understanding alterations of the serotonergic system. |
2003-03-17 |
2023-08-12 |
Not clear |
| Toshihiro Dohi, Shigeo Kitayama, Key Kumagai, Wataru Hashimoto, Katsuya Morit. [Pharmacology of monoamine neurotransmitter transporters]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 5. 2003-03-12. PMID:12491807. |
following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, net, dat, and sert, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, vmat. |
2003-03-12 |
2023-08-12 |
Not clear |
| Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Soli. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422372. |
the [(18)f]fluoromethyl analog of (+)-mcn5652 ([(18)f]fme-mcn) for imaging serotonin transporter (sert) with positron emission tomography (pet) has recently been synthesized. |
2003-03-07 |
2023-08-12 |
rat |