| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brendon P Boot, Annis O Mechan, Una D McCann, George A Ricaurt. MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398910. |
low levels of serotonin may reduce the density of the serotonin transporter (sert) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". |
2003-07-08 |
2023-08-12 |
rat |
| Brendon P Boot, Annis O Mechan, Una D McCann, George A Ricaurt. MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398910. |
to determine whether 3,4-methylenedioxymethamphetamine (mdma)-induced reductions in sert density could be related to such a mechanism, p-chlorophenylalanine or mdma was administered to rats, and brain serotonin and sert density were measured. |
2003-07-08 |
2023-08-12 |
rat |
| Brendon P Boot, Annis O Mechan, Una D McCann, George A Ricaurt. MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398910. |
this observation suggests that mdma-induced reductions in sert density do not represent neuroadaptive responses to decreased levels of brain serotonin, but may occur in response to some other stimulus or to the neurotoxic effects of mdma. |
2003-07-08 |
2023-08-12 |
rat |
| Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C Daws, Randy D Blakel. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626658. |
termination of serotonergic transmission is the function of the plasma membrane 5-hydroxytryptamine (serotonin, 5-ht) transporter (sert), which is also a high-affinity target in vivo for antidepressants, amphetamines, and cocaine. |
2003-07-07 |
2023-08-12 |
mouse |
| Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C Daws, Randy D Blakel. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626658. |
because noradrenergic stimulation is reported to influence 5-ht release, we explored possible presynaptic adrenoceptor-mediated regulation of sert. |
2003-07-07 |
2023-08-12 |
mouse |
| J L Rausch, M E Johnson, K M Corley, H M Hobby, N Shendarkar, Y Fei, V Ganapathy, F H Leibac. Depressed patients have higher body temperature: 5-HT transporter long promoter region effects. Neuropsychobiology. vol 47. issue 3. 2003-07-03. PMID:12759553. |
depression has been associated with a decrease in intracellular serotonin (5-ht) reuptake through its transporter, sert. |
2003-07-03 |
2023-08-12 |
Not clear |
| J L Rausch, M E Johnson, K M Corley, H M Hobby, N Shendarkar, Y Fei, V Ganapathy, F H Leibac. Depressed patients have higher body temperature: 5-HT transporter long promoter region effects. Neuropsychobiology. vol 47. issue 3. 2003-07-03. PMID:12759553. |
the 5-ht transporter long promoter region (5-httlpr) deletion in the sert gene has also been associated with a decrease in 5-ht reuptake. |
2003-07-03 |
2023-08-12 |
Not clear |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |
| Christopher G Tate, Jana Haase, Cara Baker, Marco Boorsma, Francesca Magnani, Yvonne Vallis, D Clive William. Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. Biochimica et biophysica acta. vol 1610. issue 1. 2003-06-03. PMID:12586388. |
the rat serotonin transporter (rsert) is an n-glycosylated integral membrane protein with 12 transmembrane regions; the n-glycans improve the ability of the sert polypeptide chain to fold into a functional transporter, but they are not required for the transmembrane transport of serotonin per se. |
2003-06-03 |
2023-08-12 |
rat |
| Christopher G Tate, Jana Haase, Cara Baker, Marco Boorsma, Francesca Magnani, Yvonne Vallis, D Clive William. Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. Biochimica et biophysica acta. vol 1610. issue 1. 2003-06-03. PMID:12586388. |
in order to define the best system for the expression, purification and structural analysis of serotonin transporter (sert), we expressed sert in escherichia coli, pichia pastoris, the baculovirus expression system and in four different stable mammalian cell lines. |
2003-06-03 |
2023-08-12 |
rat |
| Christopher G Tate, Jana Haase, Cara Baker, Marco Boorsma, Francesca Magnani, Yvonne Vallis, D Clive William. Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. Biochimica et biophysica acta. vol 1610. issue 1. 2003-06-03. PMID:12586388. |
all the mammalian cell lines expressed functional sert, but sert expressed in e. coli or p. pastoris was nonfunctional as assessed by 5-hydroxytryptamine uptake and inhibitor binding assays. |
2003-06-03 |
2023-08-12 |
rat |
| David C Purselle, Charles B Nemerof. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655305. |
these findings, taken together, suggest that alterations in the serotonergic system might contribute to suicidal behavior, serving as an impetus for researchers to scrutinize the serotonin transporter (sert) as a potential substrate for the pathophysiology of suicide. |
2003-05-29 |
2023-08-12 |
Not clear |
| Paul A T Kelly, Isobel M Ritchie, Linda Quate, Douglas E McBean, Henry J Olverma. Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain. British journal of pharmacology. vol 137. issue 7. 2003-05-20. PMID:12429568. |
in this study we have examined methylenedioxymethamphetamine (mdma)-induced toxicity in perinatal rat brain, related this to normal development of serotonin transporter sites (sert), and determined whether early exposure to mdma subsequently alters cerebral function in adults. |
2003-05-20 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Zhihong Zhu, Sung-A Bae, Ningning Guo, Yasuhiko Sudo, Lawrence S Kegeles, Marc Laruell. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). Nuclear medicine and biology. vol 29. issue 7. 2003-05-19. PMID:12381454. |
a new pet radioligand for the serotonin transporter (sert), [11c]-5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11c]dapa (10), was synthesized and evaluated in vivo in rats and baboons. |
2003-05-19 |
2023-08-12 |
rat |
| Yiyun Huang, Dah-Ren Hwang, Zhihong Zhu, Sung-A Bae, Ningning Guo, Yasuhiko Sudo, Lawrence S Kegeles, Marc Laruell. Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). Nuclear medicine and biology. vol 29. issue 7. 2003-05-19. PMID:12381454. |
moreover, such binding in sert-rich regions of the brain are blocked by pretreatment with either the selective serotonin reuptake inhibitor (ssri) citalopram and by the cold compound itself, demonstrating that [11c]dapa binding in the rat brain is saturable and specific to sert. |
2003-05-19 |
2023-08-12 |
rat |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| Carles Gil, Abderrahim Najib, José Aguiler. Serotonin transport is modulated differently by tetanus toxin and growth factors. Neurochemistry international. vol 42. issue 7. 2003-05-01. PMID:12590935. |
in spite of this, growth factors and tetx show an opposite effect on 5-ht transport, even though sert phosphorylation is enhanced in both cases. |
2003-05-01 |
2023-08-12 |
Not clear |
| J P Wisor, S W Wurts, F S Hall, K P Lesch, D L Murphy, G R Uhl, D M Edga. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport. vol 14. issue 2. 2003-04-30. PMID:12598736. |
the monoamine neurotransmitter serotonin has long been implicated in development and maintenance of sleep patterns, yet the role of the serotonin transporter (sert) in these processes has not been evaluated in detail. |
2003-04-30 |
2023-08-12 |
mouse |
| J P Wisor, S W Wurts, F S Hall, K P Lesch, D L Murphy, G R Uhl, D M Edga. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport. vol 14. issue 2. 2003-04-30. PMID:12598736. |
genetic differences in serotonin systems and developmental exposure to sert blockers are likely to exert effects on rems. |
2003-04-30 |
2023-08-12 |
mouse |
| Justine M Kent, Jeremy D Coplan, Ilise Lombardo, Dah-Ren Hwang, Yiyun Huang, Osama Mawlawi, Ronald L Van Heertum, Mark Slifstein, Anissa Abi-Dargham, Jack M Gorman, Marc Laruell. Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652. Psychopharmacology. vol 164. issue 4. 2003-04-23. PMID:12457263. |
although selective serotonin reuptake inhibitors (ssris) are widely used in the treatment of anxiety and depressive disorders, the occupancy of the serotonin reuptake transporter (sert) achieved in humans at typical clinical doses by these agents remains poorly characterized. |
2003-04-23 |
2023-08-12 |
Not clear |