| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria Arango, Mark D Underwood, J John Man. Serotonin brain circuits involved in major depression and suicide. Progress in brain research. vol 136. 2002-09-19. PMID:12143401. |
we examined whether prefrontal cortical (pfc) serotonin transporter sites (sert) differ in major depression and suicide by quantitative receptor autoradiography. |
2002-09-19 |
2023-08-12 |
Not clear |
| Victoria Arango, Mark D Underwood, J John Man. Serotonin brain circuits involved in major depression and suicide. Progress in brain research. vol 136. 2002-09-19. PMID:12143401. |
the localized reduction in sert binding in ventral pfc found in suicide victims may reflect reduced serotonin input to that brain region, underlying the predisposition to act on suicidal thoughts. |
2002-09-19 |
2023-08-12 |
Not clear |
| Lankupalle D Jayanthi, Gricelly Vargas, Louis J DeFelic. Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts. British journal of pharmacology. vol 135. issue 8. 2002-09-17. PMID:11959795. |
ne transport in rat trophoblasts is sensitive to net-specific antagonists, desipramine (ds) and nisoxetine (nx), but not to the dopamine-transporter (dat) specific antagonist, gbr12909 or to the serotonin (5ht) transporter (sert) specific antagonist paroxetine (px). |
2002-09-17 |
2023-08-12 |
human |
| Cengiz Pata, M Emin Erdal, Ebru Derici, Aziz Yazar, Arzu Kanik, Oguz Ul. Serotonin transporter gene polymorphism in irritable bowel syndrome. The American journal of gastroenterology. vol 97. issue 7. 2002-09-16. PMID:12135035. |
serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is effectively cleansed from the neuronal gap by means of a high affinity substance called serotonin transporter (sert), which depends on the na+ and cl- ions localized in the presynaptic neuronal membranes. |
2002-09-16 |
2023-08-12 |
Not clear |
| Catherine Verney, Cécile Lebrand, Patricia Gaspa. Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter. The Anatomical record. vol 267. issue 2. 2002-09-12. PMID:11997877. |
we present novel data on the immunocytochemistry of the vesicular monoamine transporter (vmat2) and of the high-affinity serotonin transporter (sert) in human fetuses. |
2002-09-12 |
2023-08-12 |
human |
| Catherine Verney, Cécile Lebrand, Patricia Gaspa. Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter. The Anatomical record. vol 267. issue 2. 2002-09-12. PMID:11997877. |
sert is a marker of the serotoninergic axons and allows visualization of the serotonin afferents of the raphe in the human telencephalon. |
2002-09-12 |
2023-08-12 |
human |
| Catherine Verney, Cécile Lebrand, Patricia Gaspa. Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter. The Anatomical record. vol 267. issue 2. 2002-09-12. PMID:11997877. |
although the present observation does not allow ascertainment of which neurons transiently express sert, it lends support to the notion that serotonin and serotonin uptake could have important developmental roles, during the formation of brain connections in humans, as they have in rodents. |
2002-09-12 |
2023-08-12 |
human |
| Stephen J Kis. How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy? Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888575. |
to date, neuroimaging studies designed to establish whether levels of brain serotonin neurons are lower than normal in ecstasy users have employed radioligands that bind to one component of the serotonin neuron, the serotonin transporter (sert). |
2002-09-11 |
2023-08-12 |
human |
| Stephen J Kis. How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy? Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888575. |
because these studies are methodologically flawed in terms of reliability or validity of the sert measurement and appear to have employed polydrug users, no definitive information is yet available on the question of ecstasy toxicity to human brain serotonin neurons. |
2002-09-11 |
2023-08-12 |
human |
| Saloua Benmansour, William A Owens, Marco Cecchi, David A Morilak, Alan Fraze. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151556. |
serotonin uptake, mediated by the serotonin transporter (sert), is blocked acutely by antidepressants such as the selective serotonin reuptake inhibitors (ssris), but such blockade does not correlate temporally with the onset of therapeutic improvement. |
2002-09-03 |
2023-08-12 |
rat |
| Saloua Benmansour, William A Owens, Marco Cecchi, David A Morilak, Alan Fraze. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151556. |
to determine if there was a temporal correlation between the time when sertraline induced downregulation of the sert and when marked alteration in sert function occurred, clearance of locally applied 5-ht into the ca3 region of hippocampus was achieved using in vivo electrochemistry. |
2002-09-03 |
2023-08-12 |
rat |
| Saloua Benmansour, William A Owens, Marco Cecchi, David A Morilak, Alan Fraze. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151556. |
after 4 or 10 d treatment with sertraline, sert binding sites decreased very little (15-30%), and the chronoamperometric signals for serotonin in sertraline-treated rats were comparable with ones obtained in control animals. |
2002-09-03 |
2023-08-12 |
rat |
| Saloua Benmansour, William A Owens, Marco Cecchi, David A Morilak, Alan Fraze. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151556. |
by contrast, after 15 d of treatment, when sert binding sites were markedly reduced by 80%, there was robust decrease in the clearance of 5-ht. |
2002-09-03 |
2023-08-12 |
rat |
| Harald Pfaar, Alexander von Holst, Daniela M Vogt Weisenhorn, Claude Brodski, Jordi Guimera, Wolfgang Wurs. mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Development genes and evolution. vol 212. issue 1. 2002-08-23. PMID:11875656. |
in these regions mpet-1 expression co-localizes precisely with the serotonin transporter (sert),which it initially precedes. |
2002-08-23 |
2023-08-12 |
mouse |
| Michael Camilleri, Elena Atanasova, Paula J Carlson, Umraan Ahmad, H Jae Kim, Blanca E Viramontes, Sanna McKinzie, Raul Urruti. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology. vol 123. issue 2. 2002-08-16. PMID:12145795. |
5-ht undergoes reuptake by a transporter protein (sert). |
2002-08-16 |
2023-08-12 |
Not clear |
| Wenxia Zhou, Kathryn A Cunningham, Mary L Thoma. Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats. Brain research. Molecular brain research. vol 100. issue 1-2. 2002-08-13. PMID:12008023. |
twenty-seven days later, brain tissue was collected to study e(2) effects on mrna expression for da d(1)-like (d(1)) and d(2)-like (d(2s), d(2l), d(3)) receptors, da transporter (dat), 5-ht(1a), 5-ht(1b), 5-ht(2a), 5-ht(2c) receptors, and 5-ht transporter (sert) as well as eralpha and erbeta in amygdala, hypothalamus, nucleus accumbens, midbrain, and ventral tegmental area (vta). |
2002-08-13 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
pups subsequently remained undisturbed until sacrifice at pd 25 and pd 60 for assessment of serotonergic damage by measuring 5-ht transporter (sert) binding in the hippocampus and neocortex as well as 5-ht and 5-hiaa concentrations (pd 25 only). |
2002-08-02 |
2023-08-12 |
rat |
| Jerrold S Meyer, Syed F Al. Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105113. |
neonatal mdma exposure led to significant reductions in both sert binding and 5-ht levels in the hippocampus at pd 25, independent of body temperature during treatment. |
2002-08-02 |
2023-08-12 |
rat |
| Urda Jess, Oussama El Far, Joachim Kirsch, Heinrich Bet. Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C. Biochemical and biophysical research communications. vol 294. issue 2. 2002-07-16. PMID:12051706. |
interaction of the c-terminal region of the rat serotonin transporter with macmarcks modulates 5-ht uptake regulation by protein kinase c. the serotonin transporter (sert) mediates the re-uptake of released serotonin into presynaptic nerve terminals. |
2002-07-16 |
2023-08-12 |
rat |
| Urda Jess, Oussama El Far, Joachim Kirsch, Heinrich Bet. Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C. Biochemical and biophysical research communications. vol 294. issue 2. 2002-07-16. PMID:12051706. |
upon cotransfection with sert, macmarcks caused a reduction in the maximal rate of [(3)h]serotonin uptake and reduced its down-regulation elicited by activation of pkc. |
2002-07-16 |
2023-08-12 |
rat |