| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Acton, S R Choi, C Hou, K Plössl, H F Kun. Quantification of serotonin transporters in nonhuman primates using [(123)I]ADAM and SPECT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 42. issue 10. 2001-11-01. PMID:11585873. |
we reported recently a highly selective radioligand, 2-([2-([dimethylamino]methyl)phenyl]thio)-5-[(123)i]iodophenylamine (adam), for spect imaging of serotonin transporters (sert). |
2001-11-01 |
2023-08-12 |
Not clear |
| M Sas. [Function of monoamine neurotransmitter transporters]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 8. 2001-10-18. PMID:11519142. |
antiepileptic drugs such as ssri and tricyclic antidepressants bind with serotonin transporter(sert), noradrenaline transporter(net) and/or dopamine transporters(dat) to inhibit transport of monoamines into the cytoplasma, thereby increasing monoamine levels within the synaptic cleft. |
2001-10-18 |
2023-08-12 |
Not clear |
| S M Scanlon, D C Williams, P Schlos. Membrane cholesterol modulates serotonin transporter activity. Biochemistry. vol 40. issue 35. 2001-09-27. PMID:11523992. |
the synaptic actions of the neurotransmitter serotonin are terminated by a selective high-affinity reuptake mediated by the serotonin transporter (sert). |
2001-09-27 |
2023-08-12 |
human |
| C Gundlah, N Z Lu, S J Mirkes, C L Bethe. Estrogen receptor beta (ERbeta) mRNA and protein in serotonin neurons of macaques. Brain research. Molecular brain research. vol 91. issue 1-2. 2001-09-20. PMID:11457488. |
for double ish, monkey specific riboprobes for erbeta incorporating radiolabeled-utp and a riboprobe for the human serotonin reuptake transporter (sert) incorporating digoxigenin were applied to midbrain sections from spayed rhesus macaques. |
2001-09-20 |
2023-08-12 |
human |
| X Liu, S Nuwayhid, M J Christie, M Kassiou, L L Werlin. Trishomocubanes: novel sigma-receptor ligands modulate amphetamine-stimulated [3H]dopamine release. European journal of pharmacology. vol 422. issue 1-3. 2001-09-13. PMID:11430911. |
several trishomocubane analogues of the type 4-azahexacyclo [5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane exhibited moderate to high affinity at sigma-receptor subtypes and low or negligible affinity at dopamine and serotonin transporters (sert). |
2001-09-13 |
2023-08-12 |
Not clear |
| Y G Ni, J G Chen, A Androutsellis-Theotokis, C J Huang, E Moczydlowski, G Rudnic. A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109. The Journal of biological chemistry. vol 276. issue 33. 2001-09-06. PMID:11408487. |
inactivation of serotonin transporter (sert) expressed in hela cells by [2-(trimethylammonium)ethyl]methanethiosulfonate (mtset) occurred much more readily when na(+) in the reaction medium was replaced with li(+). |
2001-09-06 |
2023-08-12 |
xenopus_laevis |
| Y G Ni, J G Chen, A Androutsellis-Theotokis, C J Huang, E Moczydlowski, G Rudnic. A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109. The Journal of biological chemistry. vol 276. issue 33. 2001-09-06. PMID:11408487. |
the addition of either cocaine or serotonin (5-ht) protected sert against mtset inactivation. |
2001-09-06 |
2023-08-12 |
xenopus_laevis |
| Y G Ni, J G Chen, A Androutsellis-Theotokis, C J Huang, E Moczydlowski, G Rudnic. A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109. The Journal of biological chemistry. vol 276. issue 33. 2001-09-06. PMID:11408487. |
when sert was expressed in xenopus oocytes, inward currents were elicited by superfusing the cell with 5-ht (in the presence of na(+)) or by replacing na(+) with li(+) but not nmdg(+). |
2001-09-06 |
2023-08-12 |
xenopus_laevis |
| S Horschitz, R Hummerich, P Schlos. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447330. |
the serotonin transporter (sert) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-ht) into the nerve terminal or axonal varicosities. |
2001-09-06 |
2023-08-12 |
rat |
| S Horschitz, R Hummerich, P Schlos. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447330. |
sert represents the target of various antidepressants which inhibit 5-ht transport and are widely used for the pharmacotherapy of depression. |
2001-09-06 |
2023-08-12 |
rat |
| S Horschitz, R Hummerich, P Schlos. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447330. |
here, we have analyzed the function of sert stably expressed in hek 293 cells upon exposure to citalopram, a selective serotonin reuptake inhibitor (ssri), with respect to 5-ht transport activity and protein expression as estimated by ligand binding experiments. |
2001-09-06 |
2023-08-12 |
rat |
| R Ranganathan, E R Sawin, C Trent, H R Horvit. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487610. |
the two allelic mutations defined the gene mod-5 (modulation of locomotion defective), which encodes the only serotonin reuptake transporter (sert) in c. elegans. |
2001-08-30 |
2023-08-12 |
human |
| R Ranganathan, E R Sawin, C Trent, H R Horvit. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487610. |
by contrast, other responses of c. elegans to fluoxetine were independent of mod-5 sert and 5-ht. |
2001-08-30 |
2023-08-12 |
human |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
the enteric serotonin reuptake transporter (sert) has been proposed to play a critical role in serotonergic neurotransmission and in the initiation of peristaltic and secretory reflexes. |
2001-08-30 |
2023-08-12 |
mouse |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
the guts of these animals were found to lack mrna encoding sert; moreover, high-affinity uptake of 5-ht into epithelial cells, mast cells, and enteric neurons was present in the sert +/+ bowel but absent in the sert -/- bowel. |
2001-08-30 |
2023-08-12 |
mouse |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
however, both the sert +/+ gut and the -/- gut expressed molecules capable of transporting 5-ht, but with affinities and selectivity much lower than those of sert. |
2001-08-30 |
2023-08-12 |
mouse |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
5-ht was found in all of its normal sites in the sert -/- bowel, which contained mrna encoding tryptophan hydroxylase, but no 5-ht was present in the blood of sert -/- animals. |
2001-08-30 |
2023-08-12 |
mouse |
| J J Chen, Z Li, H Pan, D L Murphy, H Tamir, H Koepsell, M D Gersho. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11487658. |
the watery diarrhea is probably attributable to the potentiation of serotonergic signaling in sert -/- mice, whereas the transient constipation may be caused by episodes of enhanced 5-ht release leading to 5-ht receptor desensitization. |
2001-08-30 |
2023-08-12 |
mouse |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
we used rt-pcr to clone monoamine transporters from macaca mulatta, macaca fasicularis and saimiri sciureus (dopamine transporter; dat) and macaca mulatta (norepinephrine transporter; net and serotonin transporter; sert). |
2001-08-09 |
2023-08-12 |
human |
| M J Millan, A Gobert, F Lejeune, A Newman-Tancredi, J M Rivet, A Auclair, J L Peglio. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. vol 298. issue 2. 2001-08-09. PMID:11454918. |
s33005 displayed marked affinity for native, rat, and cloned human serotonin (5-ht) transporters (sert) and less pronounced affinity for norepinephrine (ne) transporters (net), while its affinity at dopamine (da) transporters and >50 other sites was negligible. |
2001-08-09 |
2023-08-12 |
human |