| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
the serotonin transporters (sert) are the primary binding sites for selective serotonin reuptake inhibitors, commonly used antidepressants such as fluoxetine, sertraline, and paroxetine. |
2000-07-27 |
2023-08-12 |
rat |
| V Fabre, B Boutrel, N Hanoun, L Lanfumey, C M Fattaccini, B Demeneix, J Adrien, M Hamon, M P Martre. Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864964. |
with the aim of exploring the relationship between the serotonin transporter (5-htt or sert) and the activity level of serotonin (5-ht) neurotransmission, in vivo expression of this protein was specifically altered using a nonviral dna transfer method. |
2000-07-26 |
2023-08-12 |
rat |
| M J Owens, D L Knight, C B Nemerof. Paroxetine binding to the rat norepinephrine transporter in vivo. Biological psychiatry. vol 47. issue 9. 2000-07-18. PMID:10812044. |
the antidepressant paroxetine is believed to produce its therapeutic effects primarily by acting as a highly selective antagonist of the serotonin transporter (sert). |
2000-07-18 |
2023-08-12 |
rat |
| M M Goodman, C D Kilts, R Keil, B Shi, L Martarello, D Xing, J Votaw, T D Ely, P Lambert, M J Owens, V M Camp, E Malveaux, J M Hoffma. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755640. |
competition binding in cells stably expressing the transfected human dat serotonin transporter (sert) and norepinephrine transporter (net) labeled by [3h]win 35428, [3h]citalopram, and [3h]nisoxetine, respectively, indicated the following order of dat affinity: gbr 12909 > cit >> 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(3-fluoropropyl) nortropane (fpct) > fecnt. |
2000-07-07 |
2023-08-12 |
human |
| A Hoepping, K M Johnson, C George, J Flippen-Anderson, A P Kozikowsk. Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. Journal of medicinal chemistry. vol 43. issue 10. 2000-06-29. PMID:10821718. |
its p-methoxy analogue 5c is a mixed inhibitor of norepinephrine and serotonin reuptake (k(i) = 187 nm at the net and 56 nm at the sert). |
2000-06-29 |
2023-08-12 |
rat |
| W Liu, N Gu, G Feng, S Li, S Bai, J Zhang, T Shen, H Xue, G Breen, D St Clair, L H. Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics. vol 9. issue 4. 2000-05-12. PMID:10780268. |
the serotonin transporter gene (sert) plays an important role in the serotonin uptake into neurons. |
2000-05-12 |
2023-08-12 |
Not clear |
| V Faivre, P Manivet, J C Callaway, M M Airaksinen, H Morimoto, A Baszkin, J M Launay, V Rosili. Ligand interaction with the purified serotonin transporter in solution and at the air/water interface. FEBS letters. vol 471. issue 1. 2000-05-09. PMID:10760512. |
the purified serotonin transporter (sert) was spread at the air/water interface and the effects both of its surface density and of the temperature on its interfacial behavior were studied. |
2000-05-09 |
2023-08-12 |
Not clear |
| F Kilic, G Rudnic. Oligomerization of serotonin transporter and its functional consequences. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 7. 2000-04-24. PMID:10716733. |
two forms of serotonin transporter (sert) were prepared with different epitope tags. |
2000-04-24 |
2023-08-12 |
Not clear |
| G A Siebert, S M Pond, L J Bryan-Lluk. Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 3. 2000-04-13. PMID:10731037. |
we recently showed that haloperidol and its metabolites are inhibitors of the human noradrenaline transporter (nat), dopamine transporter (dat) and serotonin transporter (sert), and determined their ki values for inhibition of the three transporters expressed in transfected cos-7 cells. |
2000-04-13 |
2023-08-12 |
human |
| M Laruelle, A Abi-Dargham, C van Dyck, R Gil, D C D'Souza, J Krystal, J Seibyl, R Baldwin, R Inni. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. Biological psychiatry. vol 47. issue 5. 2000-03-28. PMID:10704949. |
the aim of this study was to investigate potential alterations of striatal dopamine transporters (dat) and brainstem serotonin transporters (sert) density in schizophrenia. |
2000-03-28 |
2023-08-12 |
Not clear |
| N L Flattem, R D Blakel. Modified structure of the human serotonin transporter promoter. Molecular psychiatry. vol 5. issue 1. 2000-03-17. PMID:10673778. |
recently, several studies have reported an association between anxiety traits, affective disorders and autism and alleles of a functional promoter polymorphism (5htt-lpr) in the human serotonin transporter (5htt, sert).1-3 the mechanistic basis for allelic differences in transporter transcription are presently unknown. |
2000-03-17 |
2023-08-12 |
human |
| D Xing, P Chen, R Keil, C D Kilts, B Shi, V M Camp, G Malveaux, T Ely, M J Owens, J Votaw, M Davis, J M Hoffman, R A BaKay, T Subramanian, R L Watts, M M Goodma. Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography. Journal of medicinal chemistry. vol 43. issue 4. 2000-03-16. PMID:10691690. |
competition binding in cells stably expressing the transfected human dat and serotonin transporter (sert) labeled by [(3)h]win 35428 and [(3)h]citalopram, respectively, demonstrated the following order of dat affinity (k(i) in nm): gbr 12909 (0.36) > cit (0.48) > (s)-fipct (0.67) >> (r)-fipct (3.2). |
2000-03-16 |
2023-08-12 |
human |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
in an effort to assess the role of 5-ht in drug-mediated reward, this study analyzed the serotonergic innervation of nac using immunocytochemistry for 5-ht and the 5-ht transporter (sert). |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
we report that in control rats the nac receives two distinct types of 5-ht axons that differ in regional distribution, morphology, and sert expression. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
most regions of the nac are innervated by thin 5-ht axons that express sert, but in the caudal nac shell nearly all 5-ht axons lack sert and have large spherical varicosities. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
these drug-resistant 5-ht axons that lack sert densely innervate the caudal one-third of the accumbens shell, the same location where dopamine axons are spared after methamphetamine. |
2000-03-09 |
2023-08-12 |
rat |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
the results demonstrate that two functionally different 5-ht projections innervate separate regions of the nac and that selective vulnerability to amphetamines may result from differential expression of sert. |
2000-03-09 |
2023-08-12 |
rat |
| T Sato, S Kitayama, C Mitsuhata, T Ikeda, K Morita, T Doh. Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 2. 2000-03-08. PMID:10685879. |
procaine also inhibited uptake of norepinephrine (ne) and serotonin (5-ht) by the norepinephrine transporter (net) or serotonin transporter (sert) expressed in cos cells. |
2000-03-08 |
2023-08-12 |
mouse |
| J G Chen, G Rudnic. Permeation and gating residues in serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 3. 2000-03-02. PMID:10655481. |
the third transmembrane domain (tm3) of serotonin transporter (sert) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin. |
2000-03-02 |
2023-08-12 |
Not clear |
| P D Acton, M Mu, K Plössl, C Hou, M Siciliano, Z P Zhuang, S Oya, S R Choi, H F Kun. Single-photon emission tomography imaging of serotonin transporters in the nonhuman primate brain with [(123)I]ODAM. European journal of nuclear medicine. vol 26. issue 10. 2000-02-17. PMID:10541838. |
we have described previously a selective serotonin transporter (sert) radioligand, [(123)i]idam. |
2000-02-17 |
2023-08-12 |
Not clear |