| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Lebrand, O Cases, R Wehrlé, R D Blakely, R H Edwards, P Gaspa. Transient developmental expression of monoamine transporters in the rodent forebrain. The Journal of comparative neurology. vol 401. issue 4. 1999-01-07. PMID:9826275. |
neurons in first-order sensory thalamic nuclei have been shown to express functional plasma membrane serotonin (sert) and vesicular monoamine (vmat2) transporters during early postnatal development. |
1999-01-07 |
2023-08-12 |
Not clear |
| G Fink, B E Sumner, J K McQueen, H Wilson, R Rosi. Sex steroid control of mood, mental state and memory. Clinical and experimental pharmacology & physiology. vol 25. issue 10. 1998-12-07. PMID:9784914. |
our studies in the female rat show that oestradiol, in its positive feedback mode for gonadotrophin release, increases the expression of genes for the 5-hydroxytryptamine 5-ht2a receptor and the serotonin transporter (sert) in the dorsal raphe nucleus and the density of 5-ht2a receptor and sert sites in regions of the forebrain that, in the human, are concerned with cognition, mental state, emotion and memory. |
1998-12-07 |
2023-08-12 |
human |
| A F Hoffman, C R Lupica, G A Gerhard. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. The Journal of pharmacology and experimental therapeutics. vol 287. issue 2. 1998-12-07. PMID:9808671. |
however, neither the serotonin transporter (sert) inhibitor citalopram nor the norepinephrine transporter (net) inhibitor desipramine (dmi) produced significant effects on da clearance. |
1998-12-07 |
2023-08-12 |
rat |
| H K Kramer, J C Poblete, E C Azmiti. Characterization of the translocation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) in synaptosomes: evidence for a presynaptic localization involving the serotonin transporter (SERT). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 4. 1998-11-25. PMID:9718590. |
characterization of the translocation of protein kinase c (pkc) by 3,4-methylenedioxymethamphetamine (mdma/ecstasy) in synaptosomes: evidence for a presynaptic localization involving the serotonin transporter (sert). |
1998-11-25 |
2023-08-12 |
Not clear |
| H K Kramer, J C Poblete, E C Azmiti. Characterization of the translocation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) in synaptosomes: evidence for a presynaptic localization involving the serotonin transporter (SERT). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 4. 1998-11-25. PMID:9718590. |
3, 4-methylenedioxymethamphetamine (mdma or ecstasy) is a substituted amphetamine whose acute and long-term effects on the serotonin system are dependent on an interaction with the 5-ht uptake transporter (sert). |
1998-11-25 |
2023-08-12 |
Not clear |
| B Gutiérrez, L Pintor, C Gastó, A Rosa, J Bertranpetit, E Vieta, L Fañaná. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Human genetics. vol 103. issue 3. 1998-11-19. PMID:9799087. |
the serotonin transporter (sert) gene is a particularly interesting candidate for genetic involvement in affective disorders owing to its role in both the regulation of serotonergic neurotransmission and the mechanism of action of many antidepressant drugs. |
1998-11-19 |
2023-08-12 |
human |
| R D Blakely, S Ramamoorthy, S Schroeter, Y Qian, S Apparsundaram, A Galli, L J DeFelic. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological psychiatry. vol 44. issue 3. 1998-11-06. PMID:9693389. |
although we have been aware for decades that sert-mediated 5-ht clearance can be modulated by exogenous agents including serotonin-selective reuptake inhibitors, amphetamines, and cocaine, we have had little reason to speculate that sert activity was actively controlled through endogenous pathways. |
1998-11-06 |
2023-08-12 |
Not clear |
| R D Blakely, S Ramamoorthy, S Schroeter, Y Qian, S Apparsundaram, A Galli, L J DeFelic. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological psychiatry. vol 44. issue 3. 1998-11-06. PMID:9693389. |
although many elements of this model remain hypothetical, our findings suggest a much more dynamic picture of transporter-mediated 5-ht reuptake than typically described and suggest opportunities both for the development of new sert regulatory agents and for the identification of regulatory pathways that may be compromised in mental illness. |
1998-11-06 |
2023-08-12 |
Not clear |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
we investigated the possible relationships between dna polymorphisms in the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) genes and csf concentrations of homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n = 66). |
1998-10-06 |
2023-08-12 |
human |
| A S Chang, D M Starnes, S M Chan. Possible existence of quaternary structure in the high-affinity serotonin transport complex. Biochemical and biophysical research communications. vol 249. issue 2. 1998-09-11. PMID:9712711. |
deletion-mutants of the cloned mouse serotonin transporter (sert) rendered dominant negative-mutant effects upon wild-type transporter activities in heterologous expression studies; such effects were transporter-selective and did not influence the activities of co-expressed neuronal gaba transporter. |
1998-09-11 |
2023-08-12 |
mouse |
| A K Dutta, C Xu, M E Reit. Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. Journal of medicinal chemistry. vol 41. issue 17. 1998-09-09. PMID:9703474. |
thus the potency of the compound 4a for the dat was 9.4 and 30 nm in rat striatal tissue and in the cloned transporter cells, and its binding selectivity for the dat compared to the serotonin transporter (sert) for these two systems was 62 and 195, respectively. |
1998-09-09 |
2023-08-12 |
human |
| L C Daws, G M Toney, G A Gerhardt, A Fraze. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694957. |
the effects of blockade of serotonin (5-ht) and norepinephrine (ne) transporters (sert and net, respectively) on the removal of locally applied 5-ht from extracellular fluid (ecf) were examined using in vivo chronoamperometry. |
1998-09-02 |
2023-08-12 |
rat |
| L C Daws, G M Toney, G A Gerhardt, A Fraze. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694957. |
from these data, it is inferred that in certain regions of brain (dentate gyrus), both the sert and net contribute to the active clearance of exogenously applied 5-ht. |
1998-09-02 |
2023-08-12 |
rat |
| H Ewald, T Flint, B Degn, O Mors, T A Krus. A functional variant of the serotonin transporter gene in families with bipolar affective disorder. Journal of affective disorders. vol 48. issue 2-3. 1998-07-13. PMID:9543202. |
the serotonin transporter protein (sert) reuptakes serotonin from synapses and has been implied as the site of therapeutic action of many antidepressant drugs. |
1998-07-13 |
2023-08-12 |
Not clear |
| J G Chen, S Liu-Chen, G Rudnic. Determination of external loop topology in the serotonin transporter by site-directed chemical labeling. The Journal of biological chemistry. vol 273. issue 20. 1998-06-12. PMID:9575231. |
the transmembrane topology of the serotonin transporter (sert) has been examined by measuring the reactivity of selected lysine and cysteine residues with extracellular reagents. |
1998-06-12 |
2023-08-12 |
Not clear |
| R B Rothman, M L Silverthorn, J R Glowa, D Matecka, K C Rice, F I Carroll, J S Partilla, G R Uhl, D J Vandenbergh, C M Dersc. Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517841. |
quantitative ligand binding studies revealed a novel high affinity [125i]rti-55 binding site assayed under 5-ht transporter (sert) conditions which has low affinity for almost all classic biogenic amine transporter ligands, including high affinity 5-ht transporter inhibitors such as paroxetine, but which retains high affinity for cocaine analogs. |
1998-04-30 |
2023-08-12 |
human |
| R B Rothman, M L Silverthorn, J R Glowa, D Matecka, K C Rice, F I Carroll, J S Partilla, G R Uhl, D J Vandenbergh, C M Dersc. Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517841. |
this site, termed sert(site2) for its detection under 5-ht transporter conditions (not for an association with the sert) occurs in monkey caudate, human caudate, and guinea pig caudate membranes, but not in rat caudate membranes. |
1998-04-30 |
2023-08-12 |
human |
| M Pecins-Thompson, N A Brown, C L Bethe. Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques. Brain research. Molecular brain research. vol 53. issue 1-2. 1998-04-20. PMID:9473622. |
this study examined the effect of e and p on the expression of mrna for the serotonin re-uptake transporter (sert) in monkeys using in situ hybridization and a 253 bp human sert crna probe. |
1998-04-20 |
2023-08-12 |
human |
| L C Daws, G M Toney, D J Davis, G A Gerhardt, A Fraze. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. Journal of neuroscience methods. vol 78. issue 1-2. 1998-04-14. PMID:9497010. |
male sprague-dawley rats were anaesthetized and a nafion-coated, carbon fiber electrode, attached to a multibarrel pipette, was lowered into the subgranular layer of the dentate gyrus, a region which receives dense serotonergic innervation, or the corpus callosum, a fiber tract relatively devoid of the 5-ht transporter (sert). |
1998-04-14 |
2023-08-12 |
rat |
| L C Daws, G M Toney, D J Davis, G A Gerhardt, A Fraze. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. Journal of neuroscience methods. vol 78. issue 1-2. 1998-04-14. PMID:9497010. |
taken together, these data demonstrate that in intact rats, the sert contributes to the clearance of exogenously applied 5-ht from the extracellular space. |
1998-04-14 |
2023-08-12 |
rat |