| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Daws, G M Toney, D J Davis, G A Gerhardt, A Fraze. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. Journal of neuroscience methods. vol 78. issue 1-2. 1998-04-14. PMID:9497010. |
under the experimental conditions used in this study, high-speed chronoamperometry proved to be a reliable method for directly measuring extracellular 5-ht and appears to be a valuable tool for the study of 5-ht clearance by the sert in vivo. |
1998-04-14 |
2023-08-12 |
rat |
| A K Dutta, L L Coffey, M E Reit. Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues. Journal of medicinal chemistry. vol 41. issue 5. 1998-04-14. PMID:9513598. |
biological activities of these new molecules for their binding to the dat and serotonin transporter (sert) were evaluated in rat striatal membranes. |
1998-04-14 |
2023-08-12 |
rat |
| S Ramamoorthy, E Giovanetti, Y Qian, R D Blakel. Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. The Journal of biological chemistry. vol 273. issue 4. 1998-03-03. PMID:9442097. |
17, 45-47), we demonstrated that protein kinase (pkc)-linked pathways in transfected hek-293 cells lead to the internalization of cell-surface human (h) sert protein and a reduction in 5ht uptake capacity. |
1998-03-03 |
2023-08-12 |
human |
| S A Burchett, M J Banno. Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387868. |
quantitative in situ hybridization was utilized to map the distribution and abundance of the serotonin, dopamine and norepinephrine transporter (sert, dat and net, respectively) mrnas. |
1998-02-11 |
2023-08-12 |
rat |
| A F Hoffman, G A Gerhard. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422361. |
to establish that da clearance within the sn was mediated primarily by the da transporter (dat) rather than the norepinephrine transporter (net) or the serotonin transporter (sert), we locally applied uptake inhibitors with different selectivity profiles for the various amine transporters. |
1998-02-02 |
2023-08-12 |
rat |
| M J Owens, W N Morgan, S J Plott, C B Nemerof. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400006. |
several new antidepressants that inhibit the serotonin (sert) and norepinephrine transporters (net) have been introduced into clinical practice the past several years. |
1998-01-15 |
2023-08-12 |
human |
| C Sur, P Schloss, H Bet. The rat serotonin transporter: identification of cysteine residues important for substrate transport. Biochemical and biophysical research communications. vol 241. issue 1. 1998-01-15. PMID:9405235. |
reduction and alkylation of disulfide bonds are known to affect substrate translocation by and antidepressant binding to the serotonin transporter (sert). |
1998-01-15 |
2023-08-12 |
rat |
| J G Chen, A Sachpatzidis, G Rudnic. The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding. The Journal of biological chemistry. vol 272. issue 45. 1997-12-12. PMID:9353288. |
twenty residues in the third transmembrane domain of the serotonin transporter (sert) were mutated, one at a time, to cysteine. |
1997-12-12 |
2023-08-12 |
Not clear |
| S Schroeter, A I Levey, R D Blakel. Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Molecular and cellular neurosciences. vol 9. issue 3. 1997-10-27. PMID:9245500. |
immunofluorescence experiments using antibodies specific for the sert cooh and nh2 termini, for 5ht, or for catecholamine biosynthetic enzymes suggest that sert mediates intra-cellular 5ht accumulation by epinephrine-secreting chromaffin cells. |
1997-10-27 |
2023-08-12 |
rat |
| S Schroeter, A I Levey, R D Blakel. Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Molecular and cellular neurosciences. vol 9. issue 3. 1997-10-27. PMID:9245500. |
rather, sert is highly expressed in membranes adjoining other chromaffin cells, consistent with a role for 5ht and sert in autocrine or paracrine control of chromaffin cell physiology. |
1997-10-27 |
2023-08-12 |
rat |
| S Schroeter, A I Levey, R D Blakel. Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Molecular and cellular neurosciences. vol 9. issue 3. 1997-10-27. PMID:9245500. |
these findings underscore a role for 5ht and sert in adrenal physiology, reveal unrecognized polarity of chromaffin cell plasma membranes, and warrant a consideration of common targeting mechanisms localizing amine transporters near release sites. |
1997-10-27 |
2023-08-12 |
rat |
| W E Schutzer, C L Bethe. Lack of ovarian steroid hormone regulation of norepinephrine transporter mRNA expression in the non-human primate locus coeruleus. Psychoneuroendocrinology. vol 22. issue 5. 1997-10-23. PMID:9279938. |
decreases in ovarian steroids can negatively affect mood, and drugs which block the norepinephrine transporter (net) or the serotonin transporter (sert) alleviate depression. |
1997-10-23 |
2023-08-12 |
monkey |
| W E Schutzer, C L Bethe. Lack of ovarian steroid hormone regulation of norepinephrine transporter mRNA expression in the non-human primate locus coeruleus. Psychoneuroendocrinology. vol 22. issue 5. 1997-10-23. PMID:9279938. |
we previously demonstrated that e and p alter gene expression for tryptophan hydroxylase (tph) and for the serotonin reuptake transporter (sert) in raphe neurons of the rhesus monkey. |
1997-10-23 |
2023-08-12 |
monkey |
| J K McQueen, H Wilson, G Fin. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105666. |
estradiol-17 beta increases serotonin transporter (sert) mrna levels and the density of sert-binding sites in female rat brain. |
1997-08-27 |
2023-08-12 |
rat |
| J K McQueen, H Wilson, G Fin. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105666. |
the aim of the present study was to determine the effect of estradiol-17 beta (e2), in its positive feedback mode for gonadotropin release, on the serotonin transporter (sert) in female rat brain. |
1997-08-27 |
2023-08-12 |
rat |
| J F Padbury, Y T Tseng, B McGonnigal, K Penado, M Stephan, G Rudnic. Placental biogenic amine transporters: cloning and expression. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105686. |
one is an ovine serotonin transporter (osert) with > 90% homology to the human neuronal sert. |
1997-08-27 |
2023-08-12 |
human |
| M Cinquanta, T Ratovitski, D Crespi, M Gobbi, T Mennini, R Simanto. Carrier-mediated serotonin release induced by d-fenfluramine: studies with human neuroblastoma cells transfected with a rat serotonin transporter. Neuropharmacology. vol 36. issue 6. 1997-08-18. PMID:9225308. |
the d-fenfluramine-induced [3h-]5-ht release is blocked by 0.3 microm citalopram and is dependent on the density of sert expressed per cell, but is not affected by removal of ca++ ions from the incubation medium. |
1997-08-18 |
2023-08-12 |
human |
| C Sur, H Betz, P Schlos. A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 14. 1997-08-05. PMID:9207145. |
the serotonin transporter (sert) is a member of the na+/cl--dependent neurotransmitter transporter family and constitutes the target of several clinically important antidepressants. |
1997-08-05 |
2023-08-12 |
rat |
| C Sur, H Betz, P Schlos. A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 14. 1997-08-05. PMID:9207145. |
here, replacement of serine-545 in the recombinant rat sert by alanine was found to alter the cation dependence of serotonin uptake. |
1997-08-05 |
2023-08-12 |
rat |
| C Sur, H Betz, P Schlos. A single serine residue controls the cation dependence of substrate transport by the rat serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 14. 1997-08-05. PMID:9207145. |
these results indicate that serine-545 is a crucial determinant of both the cation dependence of serotonin transport by sert and the imipramine binding properties of sert. |
1997-08-05 |
2023-08-12 |
rat |