| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Haase, A M Killian, F Magnani, C William. Regulation of the serotonin transporter by interacting proteins. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709063. |
using 5-ht uptake assays, confocal microscopy and glutathione s-transferase (gst) pull-down assays we showed that syn1a also interacts with sert and alters the subcellular localization of the transporter, resulting in a reduction of 5-ht transport. |
2002-03-12 |
2023-08-12 |
rat |
| S Horschitz, R Hummerich, P Schlos. Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709064. |
the serotonin transporter (sert), which terminates serotonergic neurotransmission by rapid re-uptake of 5-hydroxytryptamine (5-ht) back into the nerve terminal was the subject of two studies. |
2002-03-12 |
2023-08-12 |
human |
| X H Gu, R Zong, N S Kula, R J Baldessarini, J L Neumeye. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 11. issue 23. 2002-03-05. PMID:11714608. |
a series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined via competitive binding assays. |
2002-03-05 |
2023-08-12 |
Not clear |
| M Goulet, G M Miller, J Bendor, S Liu, P C Meltzer, B K Madra. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746710. |
the serotonin transporter (sert) is a principal site of action of therapeutic antidepressants in the brain. |
2002-02-05 |
2023-08-12 |
human |
| M Goulet, G M Miller, J Bendor, S Liu, P C Meltzer, B K Madra. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746710. |
the present study investigated whether, in the absence of an amine nitrogen, certain non-amines bind selectively to the sert and block the transport of serotonin. |
2002-02-05 |
2023-08-12 |
human |
| M Goulet, G M Miller, J Bendor, S Liu, P C Meltzer, B K Madra. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746710. |
the affinities of non-amines for [(3)h]citalopram binding sites on the sert and their potencies for blocking [(3)h]serotonin transport were measured in cloned human sert stably or transiently expressed in hek-293. |
2002-02-05 |
2023-08-12 |
human |
| M Goulet, G M Miller, J Bendor, S Liu, P C Meltzer, B K Madra. Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse (New York, N.Y.). vol 42. issue 3. 2002-02-05. PMID:11746710. |
the similar affinities of non-amines and conventional antidepressant drugs for the sert support the view that an amine nitrogen is not essential for drugs to block serotonin transport with high affinity. |
2002-02-05 |
2023-08-12 |
human |
| Terri L Whitworth, Laura C Herndon, Michael W Quic. Psychostimulants differentially regulate serotonin transporter expression in thalamocortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756522. |
chronic treatment with sert substrates (5-ht, 3,4-methylenedioxymethamphetamine) increased both peak sert protein levels (fourfold) and the time course of sert expression. |
2002-02-04 |
2023-08-12 |
rat |
| Terri L Whitworth, Laura C Herndon, Michael W Quic. Psychostimulants differentially regulate serotonin transporter expression in thalamocortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756522. |
these data (1) show that endogenous sert is differentially regulated by 5-ht and psychostimulants, (2) indicate that sert modulation occurs via changes in both total sert protein levels and subcellular redistribution of the transporter, and (3) suggest that some of the actions of drugs of abuse in neocortical development may be attributable to alterations in sert expression and concomitant changes in 5-ht signaling. |
2002-02-04 |
2023-08-12 |
rat |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
in suicides, there is a reduction in serotonin transporter (sert) sites and an increase in postsynaptic 5-ht(1a) receptors in localized regions of the prefrontal cortex. |
2002-01-28 |
2023-08-12 |
Not clear |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
we, therefore, examined postmortem sert binding and mrna expression, as well as 5-ht(1a) autoreceptor binding in the drn of 10 matched pairs of controls and depressed suicide victims. |
2002-01-28 |
2023-08-12 |
Not clear |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
the concentration of sert sites, sert mrna, and 5-ht(1a) binding was not different between controls and suicides (p >.05). |
2002-01-28 |
2023-08-12 |
Not clear |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
in the serotonin neurons that expressed the sert gene, expression per neuron was greater in suicides. |
2002-01-28 |
2023-08-12 |
Not clear |
| V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Man. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 6. 2002-01-28. PMID:11750182. |
less total 5-ht(1a) and sert binding is consistent with results of in vivo studies in depression. |
2002-01-28 |
2023-08-12 |
Not clear |
| S K Michelhaugh, C Fiskerstrand, E Lovejoy, M J Bannon, J P Quin. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739616. |
the dopamine (dat) and serotonin (sert) transporter genes both contain variable number of tandem repeats (vntr) in non-coding gene regions which have been correlated with a predisposition to a variety of cns disorders. |
2002-01-17 |
2023-08-12 |
human |
| A Androutsellis-Theotokis, F Ghassemi, G Rudnic. A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11592963. |
serotonin transporter (sert) contains a single reactive external cysteine residue at position 109 (chen, j. g., liu-chen, s., and rudnick, g. (1997) biochemistry 36, 1479-1486) and seven predicted cytoplasmic cysteines. |
2002-01-10 |
2023-08-12 |
rat |
| A Androutsellis-Theotokis, F Ghassemi, G Rudnic. A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11592963. |
both serotonin and cocaine protected sert from inactivation by mtsea at cys-357. |
2002-01-10 |
2023-08-12 |
rat |
| N Ginovart, A A Wilson, J H Meyer, D Hussey, S Houl. Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 11. 2001-12-18. PMID:11702049. |
[(11) c]-dasb, namely [(11) c]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile, is a new highly selective radioligand for the in vivo visualization of the serotonin transporter (sert) using positron emission tomography (pet). |
2001-12-18 |
2023-08-12 |
human |
| K Yoshimoto, B Kato, S Ueda, K Noritake, K Sakai, M Shibata, M Hori, H Kawano, Y Takeuchi, Y Wakabayashi, M Yasuhar. Dopamine and serotonin uptake inhibitors on the release of dopamine and serotonin in the nucleus accumbens of young and aged rats. Mechanisms of ageing and development. vol 122. issue 15. 2001-12-07. PMID:11557275. |
nucleus accumbens (acc) of young (4 months old) and aged (24 months old) wistar rats were perfused with dopamine (da) uptake blocker, cocaine, or the serotonin (5-ht) selective reuptake inhibitor, fluoxetine, through the microdialysis probe membrane, used to assess the dopamine transporter (dat) or serotonin transporter (sert) modulation. |
2001-12-07 |
2023-08-12 |
rat |
| O V Mortensen, A S Kristensen, O Wibor. Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants. Journal of neurochemistry. vol 79. issue 2. 2001-12-04. PMID:11677251. |
the serotonin transporter (sert) is a high-affinity sodium/chloride-dependent neurotransmitter transporter responsible for reuptake of serotonin from the extracellular space. |
2001-12-04 |
2023-08-12 |
human |