| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Z Lu, A J Eshleman, A Janowsky, C L Bethe. Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660809. |
immunofluorescent sert in serotonin soma was intracellular and similar among treatments. |
2003-11-04 |
2023-08-12 |
Not clear |
| N Z Lu, A J Eshleman, A Janowsky, C L Bethe. Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660809. |
these findings suggest that ovarian hormones regulate sert protein expression and distribution, perhaps via extracellular serotonin or mrna stability, but not solely at the level of gene transcription. |
2003-11-04 |
2023-08-12 |
Not clear |
| David Lewis, Ying Zhang, Thomas Prisinzano, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. Bioorganic & medicinal chemistry letters. vol 13. issue 7. 2003-11-03. PMID:12657288. |
a series of n-aromatic, n-heteroaromatic, and oxygenated n-phenylpropyl derivatives of 1-(2-benzhydryloxyethyl)-piperazine and 1-[2-[bis-(4-fluorophenyl)methoxy]ethyl]piperazine, analogues of gbr 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (dat) and serotonin (sert) transporter binding properties. |
2003-11-03 |
2023-08-12 |
Not clear |
| Marion Kretzschmar, Peter Brust, Jörg Zessin, Paul Cumming, Ralf Bergmann, Bernd Johannse. Autoradiographic imaging of the serotonin transporter in the brain of rats and pigs using S-([18F]fluoromethyl)-(+)-McN5652. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 13. issue 5. 2003-11-03. PMID:12957338. |
the [18f]fluoromethyl analogue of (+)-mcn5652 ([18f]fme-mcn) has recently been developed as a radioligand for imaging the neuronal serotonin transporter (sert) with positron emission tomography (pet). |
2003-11-03 |
2023-08-12 |
rat |
| Aina Westrheim Ravna, Ingebrigt Sylte, Svein G Dah. Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters. The Journal of pharmacology and experimental therapeutics. vol 307. issue 1. 2003-10-23. PMID:12944499. |
the selective serotonin reuptake inhibitors (ssris) and cocaine bind to the neural serotonin (5-ht) transporter (sert) and thus inhibit presynaptic reuptake of 5-ht and elevate its concentration in the synaptic cleft. |
2003-10-23 |
2023-08-12 |
Not clear |
| Georgianna G Gould, Marie-Christine Pardon, David A Morilak, Alan Fraze. Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12825093. |
to study this, we examined changes in binding sites in rat brain for norepinephrine (net) and serotonin transporters (sert), alpha1, alpha2, and beta1 adrenergic receptors after chronic administration of paroxetine (prx), reboxetine (rbx), or prx followed by rbx. |
2003-10-06 |
2023-08-12 |
rat |
| Cynthia L Bethea, Nicholas Z Lu, Arubala Reddy, Terry Shlaes, John M Streicher, Scott R Whittemor. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. Journal of neuroscience methods. vol 127. issue 1. 2003-09-30. PMID:12865146. |
in addition, immunofluorescence for the serotonin reuptake transporter (sert) was observed in the cell body region of undifferentiated b14 cells. |
2003-09-30 |
2023-08-12 |
rat |
| Raul R Gainetdinov, Marc G Caro. Monoamine transporters: from genes to behavior. Annual review of pharmacology and toxicology. vol 43. 2003-09-09. PMID:12359863. |
these transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. |
2003-09-09 |
2023-08-12 |
mouse |
| Ruth E Urwin, Bruce H Bennetts, Bridget Wilcken, Pierre J V Beumont, Janice D Russell, Kenneth P Nun. Investigation of epistasis between the serotonin transporter and norepinephrine transporter genes in anorexia nervosa. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12784104. |
weight-restored patients with anorexia nervosa (an) respond favorably to the selective serotonin reuptake inhibitor fluoxetine, which justifies association studies of the serotonin transporter gene (slc6a4, alias sert) and an. |
2003-09-02 |
2023-08-12 |
Not clear |
| Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vay. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. vol 20. issue 2. 2003-08-18. PMID:12794307. |
ovarian steroid hormones, estrogen and progestin, affect the function of the serotonin neural system by inhibiting serotonin re-uptake through allosteric interaction with the serotonin transporter (sert) in a nongenomic mechanism. |
2003-08-18 |
2023-08-12 |
human |
| Ling-Wei Hsin, Thomas Prisinzano, Chavon R Wilkerson, Christina M Dersch, Robert Horel, Arthur E Jacobson, Richard B Rothman, Kenner C Ric. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & medicinal chemistry letters. vol 13. issue 3. 2003-08-15. PMID:12565970. |
the analogues with a hydroxyl group in the s configuration were more selective for the dat over the serotonin transporter (sert) than the corresponding r enantiomers. |
2003-08-15 |
2023-08-12 |
Not clear |
| Tomi A Kauppinen, Kim A Bergström, Pertti Heikman, Jukka Hiltunen, Aapo K Ahone. Biodistribution and radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results. European journal of nuclear medicine and molecular imaging. vol 30. issue 1. 2003-08-01. PMID:12483421. |
[(123)i]adam [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (adam)] has recently been shown to be a very promising imaging ligand for the detection of serotonin transporters (sert) in human brain, because of its high specificity for sert. |
2003-08-01 |
2023-08-12 |
human |
| Scott V Adams, Louis J DeFelic. Flux coupling in the human serotonin transporter. Biophysical journal. vol 83. issue 6. 2003-07-31. PMID:12496095. |
the serotonin (5-hydroxytryptamine; 5ht) transporter (sert) catalyzes the movement of 5ht across cellular membranes. |
2003-07-31 |
2023-08-12 |
human |
| Scott V Adams, Louis J DeFelic. Flux coupling in the human serotonin transporter. Biophysical journal. vol 83. issue 6. 2003-07-31. PMID:12496095. |
in the brain, sert clears 5ht from extracellular spaces, modulating the strength and duration of serotonergic signaling. |
2003-07-31 |
2023-08-12 |
human |
| Scott V Adams, Louis J DeFelic. Flux coupling in the human serotonin transporter. Biophysical journal. vol 83. issue 6. 2003-07-31. PMID:12496095. |
analysis of the time course of net transport, the equilibrium 5ht gradient sustained, and the ratio of the unidirectional influx to efflux of 5ht indicate that mechanistically, human sert functions as a 5ht channel rather than a classical carrier. |
2003-07-31 |
2023-08-12 |
human |
| David R Linden, Jing-Xian Chen, Michael D Gershon, Keith A Sharkey, Gary M Maw. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 1. 2003-07-24. PMID:12646422. |
5-ht's actions are terminated by a serotonin reuptake transporter (sert). |
2003-07-24 |
2023-08-12 |
Not clear |
| David R Linden, Jing-Xian Chen, Michael D Gershon, Keith A Sharkey, Gary M Maw. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 1. 2003-07-24. PMID:12646422. |
sert inhibition increased the 5-ht concentration in media bathing-stimulated control tissue to a level comparable to that of the stimulated colitis tissue. |
2003-07-24 |
2023-08-12 |
Not clear |
| Fatima Martel, Rosario Monteiro, Clara Lemo. Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12682218. |
uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (caco-2) cells occurs through the neuronal serotonin transporter (sert). |
2003-07-24 |
2023-08-12 |
human |
| Fatima Martel, Rosario Monteiro, Clara Lemo. Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12682218. |
reverse transcriptase-polymerase chain reaction indicates that mrna of the neuronal serotonin transporter (sert) is present in caco-2 cells and in human small intestine. |
2003-07-24 |
2023-08-12 |
human |
| Irache Visiers, Harel Weinstein, Gary Rudnick, Megan M Stepha. A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry. vol 42. issue 22. 2003-07-17. PMID:12779333. |
transmembrane span 7 (tm7) of the serotonin transporter (sert) was previously subjected to random mutagenesis, and the mutation v382p was found to abolish transport activity. |
2003-07-17 |
2023-08-12 |
Not clear |