| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael D Gersho. Plasticity in serotonin control mechanisms in the gut. Current opinion in pharmacology. vol 3. issue 6. 2004-05-13. PMID:14644011. |
in the central and enteric nervous systems, sert is located in serotonergic neurons; however, these neurons are not present in the gastrointestinal mucosa, where 5-ht initiates peristaltic and secretory reflexes. |
2004-05-13 |
2023-08-12 |
Not clear |
| Michael D Gersho. Plasticity in serotonin control mechanisms in the gut. Current opinion in pharmacology. vol 3. issue 6. 2004-05-13. PMID:14644011. |
the severity of gastrointestinal effects caused by drugs that inhibit sert, such as tricyclic antidepressants, selective serotonin reuptake inhibitors and cocaine, does not usually prevent their therapeutic or recreational use because backup transporters and alterations in receptor gene expression allow the gut to adapt, albeit imperfectly, to their toxicity. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lifen Xu, Santosh S Kulkarni, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Stacey A Lomenzo, Amy Hauck Newman, Mark L Trudel. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of medicinal chemistry. vol 47. issue 7. 2004-05-10. PMID:15027858. |
3 beta-aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (dat), serotonin transporter (sert), norepinephrine transporter (net), and muscarinic (m(1)) receptors. |
2004-05-10 |
2023-08-12 |
Not clear |
| Jessica A Couch, John Chen, Heather I Rieff, Ellen M Uri, Barry G Condro. robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiation. Development (Cambridge, England). vol 131. issue 5. 2004-04-28. PMID:14973268. |
we show that in drosophila, expression of the serotonin transporter (sert) is both temporally and physically related to midline crossing. |
2004-04-28 |
2023-08-12 |
drosophila_melanogaster |
| Philippe Maurer, Sandrine Rorive, Alban de Kerchove d'Exaerde, Serge N Schiffmann, Isabelle Salmon, Yvan de Launoi. The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons. Neuroscience letters. vol 357. issue 3. 2004-04-26. PMID:15003288. |
we showed that this transcription factor is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-ht transporter (sert) and tryptophan hydroxylase (tph), two markers of the 5-ht neurotransmitter system. |
2004-04-26 |
2023-08-12 |
mouse |
| Mitchell Quinlivan, Filomena Mattner, Vahan Papazian, Jia Zhou, Andrew Katsifis, Patrick Emond, Sylvie Chalon, Alan Kozikowski, Denis Guilloteau, Michael Kassio. Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter. Nuclear medicine and biology. vol 30. issue 7. 2004-04-20. PMID:14499332. |
the tricyclic tropane analogues (1s,3s,6r,10s)-(z)-10-(benzoyloxymethyl)-9-(3-chloro-4-iodobenzylidene)-7-azatricyclo[4.3.1.0(3,7)]decane, 1, and (1s,3s,6r,10s)-(z)-9-(3-chloro-4-iodobenzylidene)-7-azatricyclo[4.3.1.0(3,7)]decane-10-carboxylic acid methyl ester, 2, have been shown to be potent and selective serotonin transporter (sert) ligands. |
2004-04-20 |
2023-08-12 |
rat |
| Christopher H van Dyck, Robert T Malison, Julie K Staley, Leslie K Jacobsen, John P Seibyl, Marc Laruelle, Ronald M Baldwin, Robert B Innis, Joel Gelernte. Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. The American journal of psychiatry. vol 161. issue 3. 2004-04-19. PMID:14992979. |
a functional polymorphism has been described in the promoter region of the gene (slc6a4) coding for the serotonin transporter protein (sert). |
2004-04-19 |
2023-08-12 |
human |
| A M Dodson, G M Anderson, K J Rhode. Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cells. Pulmonary pharmacology & therapeutics. vol 17. issue 1. 2004-04-13. PMID:14643167. |
the aim of this study was to determine whether asm cells contribute to the inactivation of serotonin, and investigate the role of the serotonin transporter (sert) and monoamine oxidase (mao) in this process. |
2004-04-13 |
2023-08-12 |
Not clear |
| A M Dodson, G M Anderson, K J Rhode. Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cells. Pulmonary pharmacology & therapeutics. vol 17. issue 1. 2004-04-13. PMID:14643167. |
the results of this study suggest that asm contributes to the uptake and metabolism of serotonin via sert and mao, respectively, and may therefore play a role in the inactivation of endogenous serotonin generated within the airway wall. |
2004-04-13 |
2023-08-12 |
Not clear |
| Catherine Verne. Phenotypic expression of monoamines and GABA in the early development of human telencephalon, transient or not transient. Journal of chemical neuroanatomy. vol 26. issue 4. 2004-04-02. PMID:14729130. |
the specific transporter for serotonin, serotonin transporter (sert) has been detected in fibers of the internal capsule (ic) during the restricted time period of 12-14 gestational weeks in humans. |
2004-04-02 |
2023-08-12 |
mouse |
| Qian Li, Li Ma, Robert B Innis, Nicholas Seneca, Masanori Ichise, Henry Huang, Marc Laruelle, Dennis L Murph. Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB). The Journal of pharmacology and experimental therapeutics. vol 308. issue 2. 2004-03-11. PMID:14610240. |
the expression and function of the serotonin transporter (sert) is important in the regulation of mood and emotion. |
2004-03-11 |
2023-08-12 |
mouse |
| Grace G Shiue, Seok-Rye Choi, Ping Fang, Catherine Hou, Paul D Acton, Chris Cardi, Janet R Saffer, Joel H Greenberg, Joel S Karp, Hank F Kung, Chyng-Yann Shiu. N,N-dimethyl-2-(2-amino-4-(18)F-fluorophenylthio)-benzylamine (4-(18)F-ADAM): an improved PET radioligand for serotonin transporters. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 44. issue 12. 2004-03-08. PMID:14660713. |
there has been considerable interest in the development of pet radioligands that are useful for imaging serotonin transporter (sert) in the living human brain. |
2004-03-08 |
2023-08-12 |
human |
| Shannon N Saldaña, Eric L Barke. Temperature and 3,4-methylenedioxymethamphetamine alter human serotonin transporter-mediated dopamine uptake. Neuroscience letters. vol 354. issue 3. 2004-03-08. PMID:14700733. |
dopamine and serotonin uptake by human sert expressed in hek-293 cells was compared at 37 and 40 degrees c. elevated temperature was found to alter serotonin transport, but had no significant effect on dopamine transport. |
2004-03-08 |
2023-08-12 |
human |
| Jie Huang, Virginia M Picke. Serotonin transporters (SERTs) within the rat nucleus of the solitary tract: subcellular distribution and relation to 5HT2A receptors. Journal of neurocytology. vol 31. issue 8-9. 2004-02-26. PMID:14501206. |
serotonergic transmission is terminated by serotonin transporter (sert)-mediated uptake following activation of serotonin receptors, several subtypes of which are present in the medial nucleus of the solitary tract (mnts) at the area postrema level. |
2004-02-26 |
2023-08-12 |
rat |
| Melanie S Johnson, Eve M Lutz, Susan Firbank, Pamela J Holland, Rory Mitchel. Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporter. Cellular signalling. vol 15. issue 8. 2004-02-20. PMID:12781873. |
stable hek-293 cell lines expressing either wild-type or haemagglutinin (ha)-tagged human 5-ht transporter (sert) were selected and sert function was confirmed using [3h]5-ht transport. |
2004-02-20 |
2023-08-12 |
human |
| G J Johnson, L A Leis, P C Dunlop, E K Wei. The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. Journal of thrombosis and haemostasis : JTH. vol 1. issue 12. 2004-02-20. PMID:14675103. |
the effects of d-fenfluramine and d-norfenfluramine on platelet uptake and efflux of 3h-5-ht were measured in buffer at ph 6.7, to optimize serotonin transporter (sert) function, and at ph 7.4. |
2004-02-20 |
2023-08-12 |
human |
| S Hesse, H Barthel, W Hermann, T Murai, R Kluge, A Wagner, O Sabri, B Egger. Regional serotonin transporter availability and depression are correlated in Wilson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 8. 2004-02-19. PMID:12898347. |
the present prospective study revealed that depressive symptomatology is related to an alteration of presynaptic serotonin transporters (sert) availability as measured by [123i]-2beta-carbomethoxy-3beta-(iodophenyl)tropane ([123i]beta-cit) and high-resolution single-photon emission computed tomography (spect). |
2004-02-19 |
2023-08-12 |
Not clear |
| Massimo Bellini, Lucia Rappelli, Corrado Blandizzi, Francesco Costa, Cristina Stasi, Rocchina Colucci, Gino Giannaccini, Donatella Marazziti, Laura Betti, Stefano Baroni, Maria Gloria Mumolo, Santino Marchi, Mario Del Tacc. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron. The American journal of gastroenterology. vol 98. issue 12. 2004-02-06. PMID:14687821. |
serotonin reuptake is mediated by a transporter protein (sert), and its dysfunctions can alter serotonergic transmission. |
2004-02-06 |
2023-08-12 |
human |
| Massimo Bellini, Lucia Rappelli, Corrado Blandizzi, Francesco Costa, Cristina Stasi, Rocchina Colucci, Gino Giannaccini, Donatella Marazziti, Laura Betti, Stefano Baroni, Maria Gloria Mumolo, Santino Marchi, Mario Del Tacc. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron. The American journal of gastroenterology. vol 98. issue 12. 2004-02-06. PMID:14687821. |
the present study examines the binding profile of platelet sert in healthy volunteers as well as in patients with diarrhea-predominant irritable bowel syndrome (d-ibs), both before and after treatment with the 5-ht(3) receptor antagonist alosetron. |
2004-02-06 |
2023-08-12 |
human |
| Swen Hesse, Henryk Barthel, Toshiya Murai, Ulrich Müller, Dominic Müller, Anita Seese, Regine Kluge, Osama Sabr. Is correction for age necessary in neuroimaging studies of the central serotonin transporter? European journal of nuclear medicine and molecular imaging. vol 30. issue 3. 2004-02-02. PMID:12536247. |
however, results from post-mortem and in vivo neuroimaging studies of the influence of age on the number of presynaptic serotonin transporters (sert) are controversial. |
2004-02-02 |
2023-08-12 |
Not clear |