| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
a dual inhibitor of acetylcholinesterase (ache) and serotonin transporter (sert), rs-1259 (4-[1s)-methylamino-3-(4-nitrophenoxy)]propylphenyl n,n-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized. |
2004-07-09 |
2023-08-12 |
mouse |
| Santosh S Kulkarni, Peter Grundt, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of medicinal chemistry. vol 47. issue 13. 2004-07-09. PMID:15189035. |
these compounds were evaluated for binding at dat, serotonin (sert) and norepinephrine (net) transporters, and muscarinic m1 receptors in rat brain. |
2004-07-09 |
2023-08-12 |
rat |
| Susan M Mitchell, Emily Lee, Mayra L Garcia, Megan M Stepha. Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15140876. |
residues 386-423 of the rat brain serotonin transporter (sert) are predicted to form a hydrophilic loop connecting transmembrane spans 7 and 8 (extracellular loop 4 or el4). |
2004-07-08 |
2023-08-12 |
rat |
| Susan M Mitchell, Emily Lee, Mayra L Garcia, Megan M Stepha. Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15140876. |
with the exception of a single mutant, f407c, neither mutation to cysteine nor treatment with mts reagents affected sert affinities for serotonin or the cocaine analog beta-cit. |
2004-07-08 |
2023-08-12 |
rat |
| David S Paterson, Richard A Belliveau, Felicia Trachtenberg, Hannah C Kinne. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. The Journal of comparative neurology. vol 472. issue 2. 2004-07-01. PMID:15048689. |
tissue receptor autoradiography with 3h-lysergic acid diethylamide (3h-lsd), 3h-8-hydroxy-2-[di-n-propylamine] tetralin (3h-8-oh-dpat), and 125i-rti-55 was used to map the distribution and developmental profile of 5-ht(1a-1d) and 5-ht2 receptors, 5-ht1a receptors, and the serotonin (5-ht) transporter (sert), respectively, to nuclei with cardiorespiratory function in the human medulla from midgestation to maturity. |
2004-07-01 |
2023-08-12 |
human |
| David S Paterson, Richard A Belliveau, Felicia Trachtenberg, Hannah C Kinne. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. The Journal of comparative neurology. vol 472. issue 2. 2004-07-01. PMID:15048689. |
with the exception of the hypoglossal nucleus, where 5-ht1a receptor binding increases while sert binding remains stable, the medullary 5-ht markers analyzed in the study are essentially "in place" at birth. |
2004-07-01 |
2023-08-12 |
human |
| Zsolt Szabo, Taofeek Owonikoko, Mark Peyrot, Jozsef Varga, William B Mathews, Hayden T Ravert, Robert F Dannals, Gary Wan. Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism. Biological psychiatry. vol 55. issue 7. 2004-06-25. PMID:15039007. |
our purpose was to investigate the serotonin transporter (sert) in various brain regions of alcoholics using positron emission tomography and c-11 mcn5652. |
2004-06-25 |
2023-08-12 |
human |
| Liesbeth Reneman, Jan Booij, Jan B A Habraken, Kora De Bruin, George Hatzidimitriou, Gerard J Den Heeten, George A Ricaurt. Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity. Synapse (New York, N.Y.). vol 46. issue 3. 2004-06-21. PMID:12325046. |
recent [123i]beta-cit single-photon emission computed tomography (spect) studies revealed decreased serotonin transporters (sert) density in the brain of humans with a history of mdma ("ecstasy") use. |
2004-06-21 |
2023-08-12 |
rat |
| Chong-Bin Zhu, William A Hewlett, Igor Feoktistov, Italo Biaggioni, Randy D Blakel. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Molecular pharmacology. vol 65. issue 6. 2004-06-21. PMID:15155839. |
whereas p38 mapk inhibition blocks neca stimulation of 5-ht activity, it fails to blunt stimulation of sert surface density. |
2004-06-21 |
2023-08-12 |
rat |
| Janet C Wanstall, Steven A Fiore, Agatha Gambino, Russell Chess-William. Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14605793. |
the aim was to determine whether uptake of 5-hydroxytryptamine (5-ht) by the 5-ht transporter (sert) modulates contractile responses to 5-ht in rat pulmonary arteries and whether this modulation is altered by exposure of rats to chronic hypoxia (10% oxygen; 8 h/day; 5 days). |
2004-06-17 |
2023-08-12 |
rat |
| Janet C Wanstall, Steven A Fiore, Agatha Gambino, Russell Chess-William. Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14605793. |
the effects of the sert inhibitor, citalopram (100 nm), on contractions to 5-ht were determined in isolated ring preparations of pulmonary artery (intralobar and main) and compared with data obtained in systemic arteries. |
2004-06-17 |
2023-08-12 |
rat |
| Janet C Wanstall, Steven A Fiore, Agatha Gambino, Russell Chess-William. Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14605793. |
it is concluded that sert can influence the concentration of 5-ht in the vicinity of the vasoconstrictor receptors in pulmonary arteries. |
2004-06-17 |
2023-08-12 |
rat |
| Janet C Wanstall, Steven A Fiore, Agatha Gambino, Russell Chess-William. Potentiation of 5-hydroxytryptamine (5-HT) responses by a 5-HT uptake inhibitor in pulmonary and systemic vessels: effects of exposing rats to hypoxia. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14605793. |
the data are compatible with reports that, in the pulmonary circulation, hypoxia induces/up-regulates sert, and hence increases 5-ht uptake, in vascular smooth muscle. |
2004-06-17 |
2023-08-12 |
rat |
| Kun-Ju Lin, Tzu-Chen Yen, Shiaw-Pyng Wey, Jeng-Jong Hwang, Xin-Xian Ye, Kai-Yuan Tzen, Ying-Kai Fu, Jin-Chung Che. Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 45. issue 4. 2004-06-03. PMID:15073265. |
imaging of serotonin transporter (sert) in the central nervous system may provide an important tool to evaluate some psychiatric disorders. |
2004-06-03 |
2023-08-12 |
mouse |
| W Gordon Frankle, Yiyun Huang, Dah-Ren Hwang, Peter S Talbot, Mark Slifstein, Ronald Van Heertum, Anissa Abi-Dargham, Marc Laruell. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 45. issue 4. 2004-06-03. PMID:15073266. |
alterations of serotonin transporters (sert) are implicated in a large number of psychiatric conditions. |
2004-06-03 |
2023-08-12 |
Not clear |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 20. 2004-06-01. PMID:13129577. |
depression seen in ad patients has been treated with serotonin transporter (sert) inhibitors. |
2004-06-01 |
2023-08-12 |
Not clear |
| Anders S Kristensen, Mads B Larsen, Laust B Johnsen, Ove Wibor. Mutational scanning of the human serotonin transporter reveals fast translocating serotonin transporter mutants. The European journal of neuroscience. vol 19. issue 6. 2004-05-28. PMID:15066148. |
the serotonin transporter (sert) belongs to a family of sodium-chloride-dependent transporters responsible for uptake of amino acids and biogenic amines from the extracellular space. |
2004-05-28 |
2023-08-12 |
human |
| Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guillotea. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. Synapse (New York, N.Y.). vol 52. issue 2. 2004-05-21. PMID:15034919. |
this may indicate in vivo competition between adam and 5-ht for binding to the sert. |
2004-05-21 |
2023-08-12 |
human |
| Sylvie Chalon, Cécile Bronquard, Johnny Vercouillie, Ercem Kodas, Lucette Garreau, Sylvie Bodard, Patrick Emond, Jean-Claude Besnard, Denis Guillotea. ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. Synapse (New York, N.Y.). vol 52. issue 2. 2004-05-21. PMID:15034919. |
the present findings thus demonstrate that adam is a specific sert radioligand which can be used for in vivo study of central serotonin systems, and supports its use as a tracer for spect studies in human disorders involving dysfunction of serotonergic neurotransmission. |
2004-05-21 |
2023-08-12 |
human |
| Michael D Gersho. Plasticity in serotonin control mechanisms in the gut. Current opinion in pharmacology. vol 3. issue 6. 2004-05-13. PMID:14644011. |
enzymes that catabolize 5-ht are all intracellular; therefore, 5-ht inactivation requires a high affinity transporter, known as serotonin transporter (sert or 5-htt). |
2004-05-13 |
2023-08-12 |
Not clear |