| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Brust, R Hinz, H Kuwabara, S Hesse, J Zessin, B Pawelke, H Stephan, R Bergmann, J Steinbach, O Sabr. In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 11. 2004-01-28. PMID:12931143. |
the radiolabeled serotonin transporter (sert) ligand [(11)c](+)-mcn5652 has recently been used in clinical positron emission tomography (pet) studies for sert imaging. |
2004-01-28 |
2023-08-12 |
Not clear |
| Charles B Nemeroff, Michael J Owen. Neuropharmacology of paroxetine. Psychopharmacology bulletin. vol 37 Suppl 1. 2004-01-28. PMID:14566196. |
paroxetine also has been shown to be a potent and selective inhibitor of the human serotonin transporter (sert) and has recently been demonstrated to have moderate affinity for the norepinephrine transporter (net). |
2004-01-28 |
2023-08-12 |
human |
| Charles B Nemeroff, Michael J Owen. Neuropharmacology of paroxetine. Psychopharmacology bulletin. vol 37 Suppl 1. 2004-01-28. PMID:14566196. |
paroxetine administration in laboratory animals has been shown to be associated with decreased sert density and function, maintenance of normal firing rates and release of 5-ht, and increased activation of postsynaptic 5-ht receptors. |
2004-01-28 |
2023-08-12 |
human |
| H Blair Simpson, Ilise Lombardo, Mark Slifstein, Henry Yiyun Huang, Dah Ren Hwang, Anissa Abi-Dargham, Michael R Liebowitz, Marc Laruell. Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biological psychiatry. vol 54. issue 12. 2004-01-26. PMID:14675806. |
this study examined whether brain serotonin transporter (sert) availability is altered in ocd using positron emission tomography (pet) and the sert pet radiotracer [(11)c]mcn 5652. |
2004-01-26 |
2023-08-12 |
Not clear |
| Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordwa. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression. Journal of psychiatric research. vol 37. issue 5. 2004-01-22. PMID:12849931. |
the specific binding of [(3)h]paroxetine to serotonin transporter (sert) and of [(3)h]lazabemide to monoamine oxidase (mao-b) were measured autoradiographically in tissue sections cut transversely at multiple levels along the rostro-caudal extent of the lc, as well as in the caudal portion of the dorsal raphe nucleus, from psychiatrically normal subjects and age-matched subjects with major depression. |
2004-01-22 |
2023-08-12 |
human |
| Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárit. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. Journal of medicinal chemistry. vol 46. issue 25. 2004-01-16. PMID:14640559. |
these compounds have been evaluated for their affinities for serotonin (5-ht) transporter (sert) and 5-ht(1a) and 5-ht(2a) receptors. |
2004-01-16 |
2023-08-12 |
Not clear |
| Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga, Ana Innerárit. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. Journal of medicinal chemistry. vol 46. issue 25. 2004-01-16. PMID:14640559. |
racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for sert than fluoxetine and resulted in lack of affinity for 5-ht(1a) and 5-ht(2a) receptors. |
2004-01-16 |
2023-08-12 |
Not clear |
| D L Murphy, G R Uhl, A Holmes, R Ren-Patterson, F S Hall, I Sora, S Detera-Wadleigh, K P Lesc. Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes, brain, and behavior. vol 2. issue 6. 2004-01-15. PMID:14653307. |
the serotonin transporter (sert, 5-htt, slc6a4) provides a relevant model for studying such interactions for several reasons: human variants in sert have been associated with several neuropsychiatric and other medical disorders and quantitative traits; sert blockers are effective treatments for a number of neuropsychiatric disorders; there is a good initial understanding of the phenotypic features of heterozygous and homozygous sert knockout mice; and there is an expanding understanding of the interactions between variations in sert expression and variations in the expression of a number of other genes of interest for neuropsychiatry and neuropharmacology. |
2004-01-15 |
2023-08-12 |
mouse |
| D L Murphy, G R Uhl, A Holmes, R Ren-Patterson, F S Hall, I Sora, S Detera-Wadleigh, K P Lesc. Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes, brain, and behavior. vol 2. issue 6. 2004-01-15. PMID:14653307. |
this paper provides examples of experimentally-obtained interactions between quantitative variations in sert gene expression and variations in the expression of five other mouse genes: dat, net, maoa, 5-ht(1b) and bdnf. |
2004-01-15 |
2023-08-12 |
mouse |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Alan Fraze. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622117. |
serotonin (5-ht) transporter (sert) function after graded destruction of serotonergic neurons. |
2004-01-14 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Alan Fraze. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622117. |
the degree of occupancy of the serotonin transporter (sert) by selective serotonin reuptake inhibitors (ssris) appears to be critical in determining therapeutic response. |
2004-01-14 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Alan Fraze. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622117. |
clearance of 5-ht was reduced only in rats with > 90% loss of sert. |
2004-01-14 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Alan Fraze. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622117. |
the ssri, fluvoxamine, prolonged clearance of 5-ht in sham, low and intermediate groups, whereas there was no effect of fluvoxamine in those rats with > 90% loss of sert. |
2004-01-14 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Alan Fraze. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622117. |
functional loss of sert activity occurs when destruction of serotonergic innervation is greater than 90% but serotonin clearance and efficacy of fluvoxamine is maintained with as few as one fifth of a full complement of serts. |
2004-01-14 |
2023-08-12 |
rat |
| C A Shively, S J Mirkes, N Z Lu, J A Henderson, C L Bethe. Soy and social stress affect serotonin neurotransmission in primates. The pharmacogenomics journal. vol 3. issue 2. 2004-01-07. PMID:12746737. |
tryptophan hydroxylase (tph) and serotonin reuptake transporter (sert) protein content were determined, and the in vitro degradation of macaque sert protein was examined in the presence and absence of protease inhibitors, serotonin (5-ht), and citalopram. |
2004-01-07 |
2023-08-12 |
monkey |
| C A Shively, S J Mirkes, N Z Lu, J A Henderson, C L Bethe. Soy and social stress affect serotonin neurotransmission in primates. The pharmacogenomics journal. vol 3. issue 2. 2004-01-07. PMID:12746737. |
thus, the hormone-induced increase in sert was accompanied by increased 5-ht synthesis and neuronal firing, which appears biologically reasonable as 5-ht prevented sert degradation in vitro. |
2004-01-07 |
2023-08-12 |
monkey |
| Tammy L Awtry, Linda L Werlin. Acute and chronic effects of nicotine on serotonin uptake in prefrontal cortex and hippocampus of rats. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515338. |
we sought to investigate the effect of nicotine exposure (chronic and acute) on serotonin transporter (sert) activity in two regions of the brain important for behavioral effects of nicotine. |
2004-01-06 |
2023-08-12 |
rat |
| Cecilia T Giambalvo, Lawrence H Pric. Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515339. |
fenfluramine releases serotonin (5-ht) via the 5-ht transporter (sert). |
2004-01-06 |
2023-08-12 |
rat |
| Cecilia T Giambalvo, Lawrence H Pric. Effects of fenfluramine and antidepressants on protein kinase C activity in rat cortical synaptoneurosomes. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515339. |
the 5-ht-mediated increase in pkc activity was attenuated by pretreatment with the 5-ht(2) antagonist ketanserin, but not with the sert inhibitor fluoxetine. |
2004-01-06 |
2023-08-12 |
rat |
| Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Bauman. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515341. |
administration of d-fenfluramine (d-fen) or parachloroamphetamine (pca) can produce long-lasting decreases in serotonin transporter (sert) binding and tissue levels of serotonin (5-ht) in rat forebrain. |
2004-01-06 |
2023-08-12 |
rat |