| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Magnani, Christopher G Tate, Samantha Wynne, Clive Williams, Jana Haas. Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin. The Journal of biological chemistry. vol 279. issue 37. 2004-10-19. PMID:15226315. |
here we show that sert associates with lipid rafts in both heterologous expression systems and rat brain and that the inclusion of the transporter into lipid microdomains is critical for serotonin uptake activity. |
2004-10-19 |
2023-08-12 |
rat |
| René Hummerich, Gerald Reischl, Walter Ehrlichmann, Hans-Jürgen Machulla, Andreas Heinz, Patrick Schlos. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312176. |
the efficiency of serotonergic signal transduction is controlled by the density of serotonegic synapses and by the activity of the serotonin transporter (sert), which selectively clears the synaptic cleft of the neurotransmitter. |
2004-09-30 |
2023-08-12 |
human |
| René Hummerich, Gerald Reischl, Walter Ehrlichmann, Hans-Jürgen Machulla, Andreas Heinz, Patrick Schlos. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312176. |
our results show that dasb selectively binds to sert with high affinity (kd = 3.5 nm) to a site distinct from the serotonin (5-ht) recognition/translocation site. |
2004-09-30 |
2023-08-12 |
human |
| René Hummerich, Gerald Reischl, Walter Ehrlichmann, Hans-Jürgen Machulla, Andreas Heinz, Patrick Schlos. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312176. |
5-ht inhibits dasb binding to sert with more than one order of magnitude lower affinity than that of dasb binding (ic50 = 82.4 nm). |
2004-09-30 |
2023-08-12 |
human |
| Zsolt Cselényi, Johan Lundberg, Christer Halldin, Lars Farde, Balázs Gulyá. Joint explorative analysis of neuroreceptor subsystems in the human brain: application to receptor-transporter correlation using PET data. Neurochemistry international. vol 45. issue 5. 2004-09-16. PMID:15234122. |
in the present study, we propose an unsupervised, unbiased data-mining tool for this task and demonstrate its usefulness by using quantitative receptor maps, obtained with positron emission tomography, from five healthy subjects on (pre-synaptic) serotonin transporters (5-htt or sert) and (post-synaptic) 5-ht(1a) receptors. |
2004-09-16 |
2023-08-12 |
human |
| Teijamari Laasonen-Balk, Heimo Viinamäki, Jyrki T Kuikka, Minna Husso-Saastamoinen, Johannes Lehtonen, Jari Tiihone. 123I-beta-CIT binding and recovery from depression. A six-month follow-up study. European archives of psychiatry and clinical neuroscience. vol 254. issue 3. 2004-08-30. PMID:15205968. |
eighteen depressive outpatients were investigated using single-photon emission computerized tomography (spect) with a high-affinity dopamine (da) and serotonin transporter (sert) specific radioligand, (123)i-labeled beta-cit (2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane). |
2004-08-30 |
2023-08-12 |
Not clear |
| Annalina Lapucci, Susanna Nencetti, Gian Carlo Demonti. Synthesis and affinity for serotonin and dopamine transporters of some benzophenone oxime ether derivatives. Farmaco (Societa chimica italiana : 1989). vol 58. issue 9. 2004-08-24. PMID:13679194. |
the present study describes the preparation of some new oxime derivatives and their capacity to inhibit serotonin (sert) and dopamine (dat) transporters expressed at the level of the rabbit cortex and the striatal membranes, respectively. |
2004-08-24 |
2023-08-12 |
rabbit |
| Olga A Tjurmina, Ines Armando, Juan M Saavedra, Qian Li, Dennis L Murph. Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Annals of the New York Academy of Sciences. vol 1018. 2004-08-18. PMID:15240357. |
this study examined whether serotonin transporter (sert) deficiency influences adrenal serotonin (5-ht), catecholamine and angiotensin ii (ang ii) systems, and the hormonal response to acute restraint stress. |
2004-08-18 |
2023-08-12 |
mouse |
| Olga A Tjurmina, Ines Armando, Juan M Saavedra, Qian Li, Dennis L Murph. Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Annals of the New York Academy of Sciences. vol 1018. 2004-08-18. PMID:15240357. |
sert-deficient mice did not express sert binding sites; their adrenal 5-ht was significantly depleted and further reduced after stress. |
2004-08-18 |
2023-08-12 |
mouse |
| Ugur Salli, Arubala P Reddy, Nurgul Salli, Nick Z Lu, Hung-Chih Kuo, Francis K-Y Pau, Don P Wolf, Cynthia L Bethe. Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons. Experimental neurology. vol 188. issue 2. 2004-08-10. PMID:15246835. |
most (>95%) of the mature cells (both small and large) were immunopositive for neuron-specific nuclear protein (neun), synaptophysin, microtubule-associated protein (map2c), tau-1, neurofilament 160 (nf-160), beta-tubulin (tujiii), tryptophan hydroxylase (tph), serotonin, the serotonin reuptake transporter (sert), estrogen receptor-beta (erbeta), and progestin receptor (pr), but not estrogen receptor-alpha (eralpha). |
2004-08-10 |
2023-08-12 |
human |
| Yuichiro Sato, Yuan-Wei Zhang, Andreas Androutsellis-Theotokis, Gary Rudnic. Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis. The Journal of biological chemistry. vol 279. issue 22. 2004-07-29. PMID:15044496. |
rat serotonin transporter (sert) tm2 was investigated by cysteine scanning mutagenesis. |
2004-07-29 |
2023-08-12 |
rat |
| Søren G F Rasmussen, Erika M Adkins, F Ivy Carroll, Martin J Maresch, Ulrik Gethe. Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612134. |
in our studies, we have focused on the serotonin transporter (sert) for which we have established a purification procedure upon expression of the transporter in sf-9 insect cells. |
2004-07-20 |
2023-08-12 |
Not clear |
| Richard B Rothman, Michael H Bauman. Monoamine transporters and psychostimulant drugs. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612135. |
we conclude that the brain contains high abundance nonclassical binding sites for cocaine-like drugs that have micromolar affinity for cocaine and that none of the clinically available amphetamine-type appetite suppressants are equipotent substrates for dopamine transporter (dat) and serotonin transporter (sert) proteins. |
2004-07-20 |
2023-08-12 |
Not clear |
| David L Roman, Crystal C Walline, Gustavo J Rodriguez, Eric L Barke. Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612137. |
the development of treatments for this disorder, beginning with the tricyclic antidepressants and leading to the development of selective serotonin reuptake inhibitors, has focused on compounds that block the function of the serotonin transporter (sert). |
2004-07-20 |
2023-08-12 |
rat |
| George R Uhl, Zhicheng Li. The top 20 dopamine transporter mutants: structure-function relationships and cocaine actions. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612139. |
third, most are also conserved in the serotonin transporter (sert), a transporter that is now strongly implicated in cocaine reward based on data from knockout mice. |
2004-07-20 |
2023-08-12 |
mouse |
| Beatriz A Roch. Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612142. |
however, the fact that cocaine similarly binds to the serotonin and norepinephrine transporters (sert and net, respectively), raises the possibility that modulation of mesocorticolimbic dopaminergic transmission might be achieved through alternate pathways. |
2004-07-20 |
2023-08-12 |
mouse |
| Claus Juul Loland, Kristine Norgaard-Nielsen, Ulrik Gethe. Probing dopamine transporter structure and function by Zn2+-site engineering. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612149. |
the biogenic amine transporters belong to the class of na+/cl--coupled solute carriers and include the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert). |
2004-07-20 |
2023-08-12 |
human |
| Patricia Gaspa. [Genetic models to understand how serotonin acts during development]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146951. |
pet-1 is selectively expressed in the raphe and controls directly the transcription of the genes, encoding the biosynthetic enzyme of 5-ht, tryptophan hydroxylase (tph), and the serotonin plasma membrane transporter (sert). |
2004-07-19 |
2023-08-12 |
mouse |
| Patricia Gaspa. [Genetic models to understand how serotonin acts during development]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146951. |
expression of sert can however occur independently of tph during development and allows subpopulations of glutamatergic neurons to take up and to store 5-ht into synaptic vesicles via the vesicular monoamine transporter (vmat). |
2004-07-19 |
2023-08-12 |
mouse |
| N Ozaki, D Goldman, W H Kaye, K Plotnicov, B D Greenberg, J Lappalainen, G Rudnick, D L Murph. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Molecular psychiatry. vol 8. issue 11. 2004-07-16. PMID:14593431. |
two common serotonin transporter (sert) untranslated region gene variants have been intensively studied, but remain inconclusively linked to depression and other neuropsychiatric disorders. |
2004-07-16 |
2023-08-12 |
Not clear |