| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephan Verleysdonk, Bernd Hamprecht, Mirna Rapp, John Wellar. Uptake and metabolism of serotonin by ependymal primary cultures. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453270. |
serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter sert, exhibiting a vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent michaelis-menten constant of 0.41+/-0.03 microm. |
2004-12-07 |
2023-08-12 |
Not clear |
| A Yeo, P Boyd, S Lumsden, T Saunders, A Handley, M Stubbins, A Knaggs, S Asquith, I Taylor, B Bahari, N Crocker, R Rallan, S Varsani, D Montgomery, D H Alpers, G E Dukes, I Purvis, G A Hick. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut. vol 53. issue 10. 2004-11-29. PMID:15361494. |
removal from its sites of action is mediated by a specific protein called the serotonin reuptake transporter (sert or 5-htt). |
2004-11-29 |
2023-08-12 |
Not clear |
| A Yeo, P Boyd, S Lumsden, T Saunders, A Handley, M Stubbins, A Knaggs, S Asquith, I Taylor, B Bahari, N Crocker, R Rallan, S Varsani, D Montgomery, D H Alpers, G E Dukes, I Purvis, G A Hick. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut. vol 53. issue 10. 2004-11-29. PMID:15361494. |
polymorphisms in the promoter region of the sert gene have effects on transcriptional activity, resulting in altered 5-ht reuptake efficiency. |
2004-11-29 |
2023-08-12 |
Not clear |
| Jennifer R O'Hara, Winnie Ho, David R Linden, Gary M Mawe, Keith A Sharke. Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis. American journal of physiology. Gastrointestinal and liver physiology. vol 287. issue 5. 2004-11-24. PMID:15231483. |
the action of mucosal 5-ht is terminated by a 5-ht reuptake transporter (sert). |
2004-11-24 |
2023-08-12 |
Not clear |
| Sandra L Hrometz, Andrew W Brown, David E Nichols, Jon E Spragu. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308297. |
several studies have suggested that dopamine (da) uptake into serotonin (5-ht) terminals by the 5-ht reuptake transporter (sert) and subsequent deamination by monoamine oxidase-b (mao-b) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. |
2004-11-24 |
2023-08-12 |
human |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
cocaine conditioned place preference (cpp) is intact in dopamine transporter (dat) knockout (ko) mice and enhanced in serotonin transporter (sert) ko mice. |
2004-11-22 |
2023-08-12 |
mouse |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
the selective sert blocker fluoxetine increases daex in cpu of dat-ko mice, while cocaine and the selective dat blocker gbr12909 increase 5-ht(ex) in cpu of sert-ko mice. |
2004-11-22 |
2023-08-12 |
mouse |
| Hao-Wei Shen, Yoko Hagino, Hideaki Kobayashi, Keiko Shinohara-Tanaka, Kazutaka Ikeda, Hideko Yamamoto, Toshifumi Yamamoto, Klaus-Peter Lesch, Dennis L Murphy, F Scott Hall, George R Uhl, Ichiro Sor. Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15226739. |
these data provide evidence that (a) cocaine increases daex in pfc independently of dat and that (b), in the absence of sert, cpu levels of 5-ht(ex) can be increased by blocking dat. |
2004-11-22 |
2023-08-12 |
mouse |
| Oliver Pogarell, Klaus Tatsch, Georg Juckel, Christine Hamann, Christoph Mulert, Gabriele Pöpperl, Malte Folkerts, Martina Choukèr, Michael Riedel, Michael Zaudig, Hans-Jürgen Möller, Ulrich Heger. Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15292904. |
the loudness dependence (ld) of the n1/p2 component of auditory evoked potentials has been proposed as a noninvasive indicator of central serotonergic function, whereas single photon emission computed tomography (spect) and [123i]beta-cit can be used to visualize both serotonin (sert) and dopamine transporters (dat). |
2004-11-22 |
2023-08-12 |
human |
| Mads Breum Larsen, Betina Elfving, Ove Wibor. The chicken serotonin transporter discriminates between serotonin-selective reuptake inhibitors. A species-scanning mutagenesis study. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15271993. |
the serotonin transporter (sert) belongs to a family of sodium chloride-dependent transporters responsible for uptake of amino acids and biogenic amines from extracellular spaces. |
2004-11-15 |
2023-08-12 |
human |
| Xiaoying Wang, Michael H Baumann, Heng Xu, Richard B Rothma. 3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266556. |
previous experiments conducted in this laboratory showed that administration of high-dose d-fenfluramine (d-fen) and p-chloroamphetamine (pca) decreased 5-ht transporter (sert) binding and tissue 5-ht by 30-60% in caudate and whole brain tissue 2 days and 2 weeks after drug administration. |
2004-11-10 |
2023-08-12 |
rat |
| Xiaoying Wang, Michael H Baumann, Heng Xu, Richard B Rothma. 3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein. Synapse (New York, N.Y.). vol 53. issue 4. 2004-11-10. PMID:15266556. |
in the present study, we studied the effect of mdma and 5,7-dihydroxytryptamine (5,7-dht) on tissue 5-ht levels and the protein expression level of sert and glial fibrillary acidic protein (gfap), a validated neurotoxicity marker. |
2004-11-10 |
2023-08-12 |
rat |
| Rohit Kolhatkar, Charles D Cook, Sujit K Ghorai, Jeffrey Deschamps, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Journal of medicinal chemistry. vol 47. issue 21. 2004-11-10. PMID:15456254. |
all synthesized derivatives were tested for their affinity at the dat, serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [(3)h]win 35, 428, [(3)h]citalopram, and [(3)h]nisoxetine, respectively. |
2004-11-10 |
2023-08-12 |
mouse |
| Hank F Kung, Suzanne Newman, Seok-Rye Choi, Shunichi Oya, Catherine Hou, Zhi-Ping Zhuang, Paul D Acton, Karl Plössl, Jeffrey Winkler, Mei-Ping Kun. 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent. Journal of medicinal chemistry. vol 47. issue 21. 2004-11-10. PMID:15456270. |
imaging serotonin transporters (sert) is an emerging research tool potentially useful to cast light on the mechanisms of drug action as well as to monitor the treatment of depressed patients. |
2004-11-10 |
2023-08-12 |
rat |
| Eugene E Nattie, Aihua Li, George B Richerson, George Richerson, Douglas A Lapp. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. The Journal of physiology. vol 556. issue Pt 1. 2004-11-09. PMID:14724193. |
we injected (2 x 100 nl) (a) substance p-saporin (sp-sap; 1 microm) to kill nk1r-expressing neurones, (b) a novel conjugate of a monoclonal antibody to the serotonin transporter (sert) and saporin (anti-sert-sap; 1 microm) to kill serotonergic neurones, or (c) sp-sap and anti-sert-sap together to kill both types. |
2004-11-09 |
2023-08-12 |
Not clear |
| Ayon Nandi, Christina M Dersch, Manish Kulshrestha, Subramaniam Ananthan, Richard B Rothma. Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter. Synapse (New York, N.Y.). vol 53. issue 3. 2004-11-09. PMID:15236350. |
in the present study we describe a novel agent, sori-6238 (ethyl 5-amino-3-(3,4-dichlorophenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-ylcarbamate) that partially inhibits 5-ht transporter (sert) binding and allosterically modulates sert function. |
2004-11-09 |
2023-08-12 |
rat |
| Adam L Numis, Erica L Unger, Douglas L Sheridan, Angela C Chisnell, Anne M Andrew. The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP). Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322265. |
mice with genetically controlled decreases in serotonin transporter (sert) expression were studied to corroborate pharmacologic evidence implicating sert in 2'-nh(2)-mptp-induced serotonin neurotoxicity. |
2004-11-03 |
2023-08-12 |
mouse |
| Adam L Numis, Erica L Unger, Douglas L Sheridan, Angela C Chisnell, Anne M Andrew. The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP). Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322265. |
in addition, complete loss of sert attenuated cortical and hippocampal depletions in 5-ht but not ne. |
2004-11-03 |
2023-08-12 |
mouse |
| James M Dorsey, Maria G Miranda, Nicholas V Cozzi, Kevin G Pinne. Synthesis and biological evaluation of 2-(4-fluorophenoxy)-2-phenyl-ethyl piperazines as serotonin-selective reuptake inhibitors with a potentially improved adverse reaction profile. Bioorganic & medicinal chemistry. vol 12. issue 6. 2004-10-21. PMID:15018922. |
preliminary data indicates that the hydrochloride (hcl) salts 10, 11, and 12 each exhibit single-site binding at the site of the serotonin reuptake transporter (sert). |
2004-10-21 |
2023-08-12 |
Not clear |
| Francesca Magnani, Christopher G Tate, Samantha Wynne, Clive Williams, Jana Haas. Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin. The Journal of biological chemistry. vol 279. issue 37. 2004-10-19. PMID:15226315. |
the serotonin transporter (sert) is an integral membrane protein responsible for the clearance of serotonin from the synaptic cleft following the release of the neurotransmitter. |
2004-10-19 |
2023-08-12 |
rat |