| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fenghua Chen, Mads Breum Larsen, Henrik Amtoft Neubauer, Connie Sánchez, Per Plenge, Ove Wibor. Characterization of an allosteric citalopram-binding site at the serotonin transporter. Journal of neurochemistry. vol 92. issue 1. 2005-02-02. PMID:15606893. |
in the present study we show that the dissociation rate, of [3h]s-citalopram from human sert, is retarded by the presence of serotonin, as well as by several antidepressants, when present in the dissociation buffer. |
2005-02-02 |
2023-08-12 |
human |
| Fenghua Chen, Mads Breum Larsen, Henrik Amtoft Neubauer, Connie Sánchez, Per Plenge, Ove Wibor. Characterization of an allosteric citalopram-binding site at the serotonin transporter. Journal of neurochemistry. vol 92. issue 1. 2005-02-02. PMID:15606893. |
dissociation of [3h]s-citalopram from sert is most potently inhibited by s-citalopram followed by r-citalopram, sertraline, serotonin and paroxetine. |
2005-02-02 |
2023-08-12 |
human |
| Bang-mao Wang, Yu-ming Wang, Wei-ming Zhang, Qing-yu Zhang, Wen-tian Liu, Kui Jiang, Jie Zhan. [Serotonin transporter gene polymorphism in irritable bowel syndrome]. Zhonghua nei ke za zhi. vol 43. issue 6. 2005-02-01. PMID:15312441. |
to investigate the association of serotonin transporter (sert) gene polymorphism with irritable bowel syndrome (ibs). |
2005-02-01 |
2023-08-12 |
Not clear |
| D Jeffrey Newport, Michael J Owens, David L Knight, Kim Ragan, Neal Morgan, Charles B Nemeroff, Zachary N Stow. Alterations in platelet serotonin transporter binding in women with postpartum onset major depression. Journal of psychiatric research. vol 38. issue 5. 2005-01-24. PMID:15380396. |
in the present study, platelet serotonin transporter (sert) binding was assessed using [(3)h]paroxetine in 14 depressed pregnant women, 31 normal healthy pregnant women, 39 depressed postpartum women, and 27 normal healthy postpartum women; all of the subjects were drug-free. |
2005-01-24 |
2023-08-12 |
human |
| Lisa J Smith, Jessica A Henderson, Creed W Abell, Cynthia L Bethe. Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 11. 2005-01-11. PMID:15199371. |
in the monkey dorsal raphe, we reported that 1-month (mo) of estrogen replacement, with or without progesterone supplementation for 14 days, significantly increased tryptophan hydroxylase-1 (tph-1) mrna; decreased serotonin reuptake transporter (sert) mrna and decreased monoamine oxidase (mao)-a mrna, but had no effect on mao-b mrna. |
2005-01-11 |
2023-08-12 |
monkey |
| Swen Hesse, Henryk Barthel, Johannes Schwarz, Osama Sabri, Ulrich Mülle. Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders. Neuroscience and biobehavioral reviews. vol 28. issue 6. 2005-01-11. PMID:15527862. |
alterations of central serotonergic neurotransmission, particularly changes in the presynaptically located serotonin transporter (sert) availability, are thought to be one of the major pathomechanisms of neuropsychiatric symptoms. |
2005-01-11 |
2023-08-12 |
Not clear |
| Swen Hesse, Henryk Barthel, Johannes Schwarz, Osama Sabri, Ulrich Mülle. Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders. Neuroscience and biobehavioral reviews. vol 28. issue 6. 2005-01-11. PMID:15527862. |
we furthermore elucidate the potential of sert imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors. |
2005-01-11 |
2023-08-12 |
Not clear |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. Bioorganic & medicinal chemistry letters. vol 14. issue 12. 2005-01-06. PMID:15149693. |
a series of racemic 6-hydroxy and carboalkoxy substituted-4('),4"-difluorobenztropines was synthesized and evaluated for binding at the dopamine (dat), the serotonin (sert), the norepinephrine (net) transporters, and the muscarinic m1 receptor. |
2005-01-06 |
2023-08-12 |
Not clear |
| Tommi Tolmunen, Mikko Joensuu, Pirjo Irmeli Saarinen, Hanna Mussalo, Pasi Ahola, Ritva Vanninen, Jyrki Kuikka, Jari Tiihonen, Johannes Lehtone. Elevated midbrain serotonin transporter availability in mixed mania: a case report. BMC psychiatry. vol 4. 2004-12-30. PMID:15363105. |
results obtained from brain imaging studies indicate that serotonin transporter (sert) and dopamine transporter (dat) densities are altered in major depression. |
2004-12-30 |
2023-08-12 |
Not clear |
| Frederic Bois, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis, Gilles Tamagna. Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorganic & medicinal chemistry letters. vol 14. issue 9. 2004-12-22. PMID:15080991. |
all 3'-substituted compounds displayed affinity for both serotonin (sert) and dopamine (dat), but much less for norepinephrine transporters (net), with selectivity for rat (r) or human (h) sert over net, but only 3'-iodo-substituted phenyltropanes showed selectivity for sert versus dat. |
2004-12-22 |
2023-08-12 |
human |
| Ping Fang, Grace G Shiue, Tomokazu Shimazu, Joel H Greenberg, Chyng-Yann Shiu. Synthesis and evaluation of N,N-dimethyl-2-(2-amino-5-[18F]fluorophenylthio)benzylamine (5-[18F]-ADAM) as a serotonin transporter imaging agent. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 61. issue 6. 2004-12-22. PMID:15388117. |
the synthesis and evaluation of a new serotonin transporter (sert) imaging agent, n,n-dimethyl-2-(2-amino-5-[18f]fluorophenylthio)benzylamine (5-[18f]-adam) is reported. |
2004-12-22 |
2023-08-12 |
rat |
| Akira Kugaya, Gerard Sanacora, Julie K Staley, Robert T Malison, Ali Bozkurt, Shaukat Khan, Amit Anand, Christopher H Van Dyck, Ronald M Baldwin, John P Seibyl, Dennis Charney, Robert B Inni. Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors. Biological psychiatry. vol 56. issue 7. 2004-12-21. PMID:15450785. |
few studies have investigated the predictive value of central serotonin transporter (sert) availability for treatment response to serotonin reuptake inhibitors (ssris). |
2004-12-21 |
2023-08-12 |
Not clear |
| E Keating, C Lemos, R Monteiro, I Azevedo, F Marte. The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT. Life sciences. vol 76. issue 1. 2004-12-21. PMID:15501483. |
the effect of a series of organic cations upon the plasmalemmal serotonin transporter, sert. |
2004-12-21 |
2023-08-12 |
human |
| E Keating, C Lemos, R Monteiro, I Azevedo, F Marte. The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT. Life sciences. vol 76. issue 1. 2004-12-21. PMID:15501483. |
the aim of this work was to test the effect of a series of organic cations upon the activity of the plasma membrane serotonin transporter (sert). |
2004-12-21 |
2023-08-12 |
human |
| B Bottalico, I Larsson, J Brodszki, E Hernandez-Andrade, B Casslén, K Marsál, S R Hansso. Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. Placenta. vol 25. issue 6. 2004-12-17. PMID:15135235. |
norepinephrine transporter (net), serotonin transporter (sert), vesicular monoamine transporter (vmat2) and organic cation transporters (oct1, 2 and emt) in human placenta from pre-eclamptic and normotensive pregnancies. |
2004-12-17 |
2023-08-12 |
human |
| Yiyun Huang, Dah-Ren Hwang, Sung-A Bae, Yasuhiko Sudo, Ningning Guo, Zhihong Zhu, Raj Narendran, Marc Laruell. A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM). Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219271. |
the synthesis, radiolabeling, and in vitro and in vivo evaluation of a new positron emission tomography (pet) radioligand for the serotonin transporter (sert), [(11)c]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([(11)c]afm) is reported. |
2004-12-14 |
2023-08-12 |
human |
| Xin-Xian Ye, Jyh-Cheng Chen, Ren-Shen Liu, Shiaw-Pyng Wey, Jin-Shin Lee, Chia-Chieh Chen, Ying-Kai Fu, Gann Ting, Jeng-Jong Hwan. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219272. |
a radiopharmaceutical, (123)i-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([(123)i]adam), has been developed recently for evaluation of how serotonin transporters (sert) function in the brain. |
2004-12-14 |
2023-08-12 |
mouse |
| Xin-Xian Ye, Jyh-Cheng Chen, Ren-Shen Liu, Shiaw-Pyng Wey, Jin-Shin Lee, Chia-Chieh Chen, Ying-Kai Fu, Gann Ting, Jeng-Jong Hwan. Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219272. |
fluoxetine and desipramine, both are psychotropics and specific sert ligands and decreased the affinity of [(123)i]adam, while p-chloroamphetamine (pca), a narcotic, destroyed most of serotonergic neurons, as well as reducing the concentration of serotonin and the number of sert in the brain as shown by the biodistribution of [(123)i]adam. |
2004-12-14 |
2023-08-12 |
mouse |
| Jos L H Eersels, Rob P Klok, Joost Verbeek, Allard J Jonker, Jacobus D M Herschei. Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter. Nuclear medicine and biology. vol 31. issue 5. 2004-12-14. PMID:15219273. |
to evaluate their potential as spect ligands for the serotonin transporter (sert), the biodistribution of both ligands was determined and pretreatment "blocking" studies performed. |
2004-12-14 |
2023-08-12 |
Not clear |
| Signe í Stórustovu, Connie Sánchez, Peter Pörzgen, Lise T Brennum, Anna Kirstine Larsen, Monica Pulis, Bjarke Eber. R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter. British journal of pharmacology. vol 142. issue 1. 2004-12-07. PMID:15037515. |
since r-citalopram is at least 20-fold weaker than s-citalopram as inhibitor of the 5-ht transporter (sert) in preclinical studies, the clinical data suggest an unexpected antagonistic interaction between the two enantiomers. |
2004-12-07 |
2023-08-12 |
human |