| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorganic & medicinal chemistry letters. vol 15. issue 4. 2005-06-15. PMID:15686927. |
among these, compound 4b exhibited very high affinity for the serotonin transporter (sert: k(i)=17 pm) and good selectivity over dopamine (dat: 710-fold) and norepinephrine transporters (net: 11,100-fold). |
2005-06-15 |
2023-08-12 |
Not clear |
| Jochanan Stessman, Yoram Maaravi, Robert Hammerman-Rozenberg, Aaron Cohen, Lubov Nemanov, Inga Gritsenko, Nelly Gruberman, Richard P Ebstei. Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. Mechanisms of ageing and development. vol 126. issue 2. 2005-06-13. PMID:15621215. |
in an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein e (apoe), methylenetetrahydrofolate reductase (mthfr), cathepsin d (cad), superoxide dismutase 2 (sod2), angiotensinogen (agt) and insulin-like growth factor 2 (igf2), leiden factor 7, p53 oncogene, dopamine d4 receptor (drd4) and the serotonin transporter (sert). |
2005-06-13 |
2023-08-12 |
human |
| Ilana Kremer, Rachel Bachner-Melman, Alon Reshef, Leonid Broude, Lubov Nemanov, Inga Gritsenko, Uriel Heresco-Levy, Yoel Elizur, Richard P Ebstei. Association of the serotonin transporter gene with smoking behavior. The American journal of psychiatry. vol 162. issue 5. 2005-06-08. PMID:15863794. |
in an ongoing molecular genetic study of temperament, participants were genotyped to examine the association of smoking with two polymorphisms of the serotonin transporter gene (sert): the promoter region, 5-httlpr, and an intronic variable-number-of-tandem-repeats region (vntr). |
2005-06-08 |
2023-08-12 |
human |
| Maartje M L de Win, Jan B A Habraken, Liesbeth Reneman, Wim van den Brink, Gerard J den Heeten, Jan Booi. Validation of [(123)I]beta-CIT SPECT to assess serotonin transporters in vivo in humans: a double-blind, placebo-controlled, crossover study with the selective serotonin reuptake inhibitor citalopram. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 5. 2005-05-12. PMID:15770240. |
the 5-ht system can be studied in vivo by measuring 5-ht transporter (sert) densities using (123)iodine-labeled 2beta-carbomethoxy-3beta(4-iodophenyl)tropane ([(123)i]beta-cit) and single photon emission computed tomography (spect). |
2005-05-12 |
2023-08-12 |
human |
| Peter S Talbot, W Gordon Frankle, Dah-Ren Hwang, Yiyun Huang, Raymond F Suckow, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans. Synapse (New York, N.Y.). vol 55. issue 3. 2005-05-11. PMID:15605360. |
here, we investigated in humans the effects of reduced synaptic 5-ht on the in vivo binding of the 5-ht transporter (sert) radioligand (11)c-dasb, using positron emission tomography (pet) and the rapid tryptophan depletion (rtd) technique. |
2005-05-11 |
2023-08-12 |
human |
| T Kakiuchi, H Tsukada, D Fukumoto, S Nishiyam. Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain: PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys. Synapse (New York, N.Y.). vol 40. issue 3. 2005-05-09. PMID:11304754. |
age-related changes in the serotonin transporter (sert) in the living brains of conscious young (5.9 +/- 1.8 years old) and aged (19.0 +/- 3.3 years old) monkeys (macaca mulatta) were evaluated in combination with [(11)c](+)mcn5652 and its inactive enantiomer [(11)c](-)mcn5652 by high-resolution positron emission tomography (pet). |
2005-05-09 |
2023-08-12 |
monkey |
| Débora C Hipólide, Karin M Moreira, Karen B L Barlow, Alan A Wilson, José N Nobrega, Sergio Tufi. Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 2. 2005-05-09. PMID:15694238. |
in the present study we examined the possibility that such changes may occur at the level of the norepinephrine (net) and serotonin (sert) and transporters. |
2005-05-09 |
2023-08-12 |
rat |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
the serotonin transporter (sert) is a neuronal plasma membrane protein whose primary function is to take up the neurotransmitter serotonin from the extracellular space, thereby controlling the spatial and temporal aspects of serotonergic signaling in the brain. |
2005-05-05 |
2023-08-12 |
mouse |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
in humans, a commonly expressed genetic variant of the serotonin transporter gene results in 40% reductions in sert expression that have been linked to increases in anxiety-related personality traits and susceptibility to stress-associated depression. |
2005-05-05 |
2023-08-12 |
mouse |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
mice have been engineered to express similar reductions in sert expression to investigate transporter-mediated control of serotonin neurotransmission and behavior. |
2005-05-05 |
2023-08-12 |
mouse |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
we employed carbon fiber microelectrode voltammetry (chronoamperometry) to examine serotonin clearance rates in brain liposomes (synaptosomes) prepared from mice with 50% (sert(+/)(-)) or complete (sert(-)(/)(-)) loss of sert expression. |
2005-05-05 |
2023-08-12 |
mouse |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
most notably, unlike prior studies using established radiochemical methods in synaptosomes, we determined 60% reductions in serotonin uptake rates in sert(+/)(-) mice in two different brain regions-striatum and frontal cortex. |
2005-05-05 |
2023-08-12 |
mouse |
| Xiomara A Perez, Anne M Andrew. Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice. Analytical chemistry. vol 77. issue 3. 2005-05-05. PMID:15679349. |
serotonin uptake was not detected in either brain region in sert(-)(/)(-) mice. |
2005-05-05 |
2023-08-12 |
mouse |
| Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruell. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801845. |
a series of new, fluorine-containing substituted diphenyl sulfides was synthesized to serve as candidate ligands for positron emission tomography (pet) imaging of the serotonin transporter (sert) and to further probe the structure-activity relationship (sar) of this class of compounds. |
2005-05-05 |
2023-08-12 |
human |
| Brian J Piper, Jerrold S Meye. Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacology, biochemistry, and behavior. vol 79. issue 4. 2005-04-29. PMID:15582680. |
brain tissues were collected at pd 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (sert) in the neocortex and hippocampus. |
2005-04-29 |
2023-08-12 |
human |
| Yinglin Liu, Yuichiro J Suzuki, Regina M Day, Barry L Fanbur. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circulation research. vol 95. issue 6. 2005-04-26. PMID:15297378. |
5-ht activated rock, and the activation was blocked by gr 55562 and gr127935, 5-ht 1b/1d receptor antagonists, but not by serotonin transport (sert) inhibitors. |
2005-04-26 |
2023-08-12 |
Not clear |
| Markus Mitterhauser, Wolfgang Wadsak, Leonhard-Key Mien, Alexander Hoepping, Helmut Viernstein, Robert Dudczak, Kurt Klette. Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter. Synapse (New York, N.Y.). vol 55. issue 2. 2005-04-25. PMID:15529336. |
an important improvement, yielding in higher affinity to the dopamine transporter (dat) vs. serotonin transporter (sert), can be achieved by a simple replacement of the carboxylic methyl ester group in beta-cit by a fluoroethyl ester. |
2005-04-25 |
2023-08-12 |
rat |
| Scott F Stoltenber. Epistasis among presynaptic serotonergic system components. Behavior genetics. vol 35. issue 2. 2005-04-14. PMID:15685432. |
because 5-ht dysregulation is associated with several common psychiatric disorders, the potential for epistasis among genetic variants in the 5-ht transporter (sert), 5-ht1b terminal autoreceptor and the 5-ht1a somatodendritic autoreceptor should be examined. |
2005-04-14 |
2023-08-12 |
Not clear |
| Scott F Stoltenber. Epistasis among presynaptic serotonergic system components. Behavior genetics. vol 35. issue 2. 2005-04-14. PMID:15685432. |
parameters representing extracellular 5-ht clearance rates (sert), 5-ht release levels (5-ht1b) and inhibitory thresholds (the amount of extracellular 5-ht above which cell firing is inhibited, an indication of 5-ht1a autoreceptor sensitivity) were varied to simulate genetic deletion (i.e. |
2005-04-14 |
2023-08-12 |
Not clear |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & medicinal chemistry. vol 12. issue 23. 2005-04-13. PMID:15519172. |
both cis and trans 2,4- and 3,6-disubstituted derivatives were synthesized to determine the positional importance of n-substitution on affinity for monoamine transporters, that is the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain. |
2005-04-13 |
2023-08-12 |
rat |