| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allan Lawrie, Edda Spiekerkoetter, Eliana C Martinez, Noona Ambartsumian, W John Sheward, Margaret R MacLean, Anthony J Harmar, Ann-Marie Schmidt, Eugene Lukanidin, Marlene Rabinovitc. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circulation research. vol 97. issue 3. 2005-10-20. PMID:16002749. |
because 5-ht induces release of s100beta, we investigated the codependence of 5-ht receptors and sert in regulating s100a4/mts1 in human pulmonary artery smooth muscle cells (hpa-smc). |
2005-10-20 |
2023-08-12 |
human |
| Allan Lawrie, Edda Spiekerkoetter, Eliana C Martinez, Noona Ambartsumian, W John Sheward, Margaret R MacLean, Anthony J Harmar, Ann-Marie Schmidt, Eugene Lukanidin, Marlene Rabinovitc. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circulation research. vol 97. issue 3. 2005-10-20. PMID:16002749. |
5-ht signaling mediated phosphorylation (p) of extracellular signal-regulated kinase 1/2 (perk1/2), but perk1/2 nuclear translocation depended on sert, monoamine oxidase activity, and reactive oxygen species. |
2005-10-20 |
2023-08-12 |
human |
| P Brust, U Scheffel, Z Szab. Radioligands for the study of the 5-HT transporter in vivo. IDrugs : the investigational drugs journal. vol 2. issue 2. 2005-10-13. PMID:16160948. |
loss of 5-ht transporter (sert) sites has been implicated in various neurodegenerative diseases and users of some amphetamine derivatives such as mdma. |
2005-10-13 |
2023-08-12 |
human |
| Kirsten R Müller-Vahl, Geerd J Meyer, Wolfram H Knapp, Hinderk M Emrich, Peter Gielow, Thomas Brücke, Georg Berdin. Serotonin transporter binding in Tourette Syndrome. Neuroscience letters. vol 385. issue 2. 2005-10-11. PMID:15936877. |
we, therefore, used [i-123]2[beta]-carbomethoxy-3[beta]-(4-iodophenyl)tropane ([123i]beta-cit) and single photon emission computed tomography (spect) to investigate serotonin transporter (sert) binding capacity in 12 patients with ts with various degrees of associated obsessive compulsive behaviour (ocb) and 16 age-matched healthy controls. |
2005-10-11 |
2023-08-12 |
Not clear |
| Ana M Catafau, Víctor Pérez, María M Penengo, Santiago Bullich, Mónica Danús, Dolors Puigdemont, Juan C Pascual, Iluminada Corripio, Jordi Llop, Javier Perich, Enric Alvare. SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 8. 2005-10-03. PMID:16085586. |
(123)i-adam (2-([2-([dimethylamino]methyl)phenyl]thio)-5-(123)i-iodophenylamine) has been recently proposed as a new serotonin transporter (sert) ligand for spect. |
2005-10-03 |
2023-08-12 |
human |
| Barbara Nightingale, Christina M Dersch, Terrence L Boos, Elisabeth Greiner, William J Calhoun, Arthur E Jacobson, Kenner C Rice, Richard B Rothma. Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15860577. |
we report here on a partial inhibitor of 5-ht transporter (sert) binding identified among a group of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine analogs (4-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-1-(2-trifluoromethyl-benzyl)-piperidine; tb-1-099). |
2005-09-30 |
2023-08-12 |
human |
| Nachwa Jarkas, John R Votaw, Ronald J Voll, Larry Williams, Vernon M Camp, Michael J Owens, David C Purselle, J Douglas Bremner, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. Nuclear medicine and biology. vol 32. issue 3. 2005-09-29. PMID:15820756. |
carbon-11-labeled n,n-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (homadam) was synthesized as a new serotonin transporter (sert) imaging agent. |
2005-09-29 |
2023-08-12 |
Not clear |
| Skirmantas Janusoni. Serotonergic paradoxes of autism replicated in a simple mathematical model. Medical hypotheses. vol 64. issue 4. 2005-09-27. PMID:15694691. |
the serotonin transporter (sert) controls 5-ht uptake by blood platelets and has been implicated in autism, but recent studies have found no correlation between sert polymorphisms and autism. |
2005-09-27 |
2023-08-12 |
Not clear |
| James S Sutcliffe, Ryan J Delahanty, Harish C Prasad, Jacob L McCauley, Qiao Han, Lan Jiang, Chun Li, Susan E Folstein, Randy D Blakel. Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American journal of human genetics. vol 77. issue 2. 2005-09-23. PMID:15995945. |
elevated platelet serotonin (5-ht) in 20%-25% of cases and efficacy of selective 5-ht reuptake inhibitors (ssris) in treating anxiety, depression, and repetitive behaviors points to the 5-ht transporter (5-htt; sert) as a strong candidate gene. |
2005-09-23 |
2023-08-12 |
Not clear |
| Kazufumi Hirano, Ryohei Kimura, Yumi Sugimoto, Jun Yamada, Shinya Uchida, Yasuhiro Kato, Hisakuni Hashimoto, Shizuo Yamad. Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. British journal of pharmacology. vol 144. issue 5. 2005-09-22. PMID:15678084. |
the present study was undertaken to characterise the relationship between in vivo brain serotonin transporter (sert) binding, plasma concentration and pharmacological effect of selective serotonin reuptake inhibitors (ssris) in mice. |
2005-09-22 |
2023-08-12 |
mouse |
| Stephen J Kish, Yoshiaki Furukawa, Li-Jan Chang, Junchao Tong, Nathalie Ginovart, Alan Wilson, Sylvain Houle, Jeffrey H Meye. Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? Nuclear medicine and biology. vol 32. issue 2. 2005-09-08. PMID:15721757. |
the primary approach in assessing the status of brain serotonin neurons in human conditions such as major depression and exposure to the illicit drug ecstasy has been the use of neuroimaging procedures involving radiotracers that bind to the serotonin transporter (sert). |
2005-09-08 |
2023-08-12 |
human |
| Andrea Cappelli, Germano Giuliani, Andrea Gallelli, Salvatore Valenti, Maurizio Anzini, Laura Mennuni, Francesco Makovec, Aroldo Cupello, Salvatore Vomer. Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor. Bioorganic & medicinal chemistry. vol 13. issue 10. 2005-09-08. PMID:15848758. |
a series of quipazine derivatives, previously synthesized to probe the 5-ht(3) receptor, was evaluated for its potential interaction with serotonin transporter (sert). |
2005-09-08 |
2023-08-12 |
Not clear |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
pma-evoked release could be partially blocked by pre-treatment with a serotonin (5-ht) reuptake inhibitor, suggesting that evoked 5-ht release contributed to the electrochemical signal and was mediated by the 5-ht transporter (sert). |
2005-09-08 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
to study the effect of these amphetamines on clearance of 5-ht mediated specifically by the sert, clearance of exogenously applied 5-ht was measured in the ca3 region of the hippocampus. |
2005-09-08 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
in contrast to the striatum where 5-ht is cleared by both the sert and the dopamine transporter (dat), 5-ht is cleared primarily by the sert in the ca3 region. |
2005-09-08 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
these data demonstrate in vivo (1) brain region variability in the ability of pma and mdma to evoke release of neurotransmitter; (2) that clearance of 5-ht in the striatum is mediated by both the sert and the dat; (3) distinct differences in the amount and nature of neurotransmitter released in the striatum after local application of pma and mdma and (4) that pma is a more efficacious inhibitor of 5-ht clearance in the hippocampus than mdma. |
2005-09-08 |
2023-08-12 |
rat |
| D R Linden, K F Foley, C McQuoid, J Simpson, K A Sharkey, G M Maw. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 17. issue 4. 2005-09-06. PMID:16078946. |
during inflammation, sert transcript levels and immunoreactivity were reduced, and the uptake of [3h] 5-ht was impaired. |
2005-09-06 |
2023-08-12 |
mouse |
| Michael T Williams, Tori L Schaefer, Lisa A Ehrman, Jessica A Able, Gary A Gudelsky, Renu Sah, Charles V Vorhee. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research. vol 1039. issue 1-2. 2005-08-30. PMID:15781051. |
3,4-methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering sert activity. |
2005-08-30 |
2023-08-12 |
rat |
| Catherine M Dempsey, Scott M Mackenzie, Andrew Gargus, Gabriela Blanco, Ji Ying Sz. Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. Genetics. vol 169. issue 3. 2005-08-29. PMID:15654117. |
using the well-established serotonergic response in c. elegans egg-laying behavior as a paradigm, we show that action of fluoxetine and imipramine at the 5ht reuptake transporter (sert) and at 5ht receptors are separable mechanisms. |
2005-08-29 |
2023-08-12 |
caenorhabditis_elegans |
| Catherine M Dempsey, Scott M Mackenzie, Andrew Gargus, Gabriela Blanco, Ji Ying Sz. Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior. Genetics. vol 169. issue 3. 2005-08-29. PMID:15654117. |
even mutants completely lacking 5ht or sert can partially respond to fluoxetine and imipramine. |
2005-08-29 |
2023-08-12 |
caenorhabditis_elegans |