| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anu J Airaksinen, Marko Huotari, Alexander Shvetsov, Pirjo Vainiotalo, Pekka T Männisto, Leena Tuomisto, Kim A Bergström, Jouko Vepsäläine. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. European journal of medicinal chemistry. vol 40. issue 3. 2005-08-29. PMID:15725499. |
the effect of 6/7-groups was evaluated by in vitro receptor binding to dopamine (dat), serotonin (sert) and norepinephrine (net) transporters. |
2005-08-29 |
2023-08-12 |
mouse |
| Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, Sándor Antu. Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15831439. |
mdma and eight chemically defined byproducts of mdma synthesis were investigated for their interaction with the primary sites of action of mdma, namely the human plasmalemmal monamine transporters for norepinephrine, serotonin, and dopamine [(norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat)]. |
2005-08-26 |
2023-08-12 |
human |
| Alexander D Dmitriev, Magnolia I Factor, Olga L Segal, Elena V Pavlova, Yulia S Massino, Maria B Smirnova, Dinora A Yakovleva, Dmitriy A Dmitriev, Elena A Kizim, Galina I Kolyaskina, Oleg S Bruso. Western blot analysis of human and rat serotonin transporter in platelets and brain using site-specific antibodies: evidence that transporter undergoes endoproteolytic cleavage. Clinica chimica acta; international journal of clinical chemistry. vol 356. issue 1-2. 2005-08-25. PMID:15936305. |
serotonin transporter (sert) is important target molecule for many antidepressive drugs and substances of abuse and is implicated in psychiatric disorders. |
2005-08-25 |
2023-08-12 |
human |
| Aroldo Cupello, Emilio Favale, Daniela Audenino, Simona Scarrone, Stefania Gastaldi, Claudio Alban. Decrease of serotonin transporters in blood platelets after epileptic seizures. Neurochemical research. vol 30. issue 4. 2005-08-24. PMID:16076011. |
serotonin transporter (sert) was studied by [3h]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. |
2005-08-24 |
2023-08-12 |
Not clear |
| Karen Søeby, Svend A Larsen, Line Olsen, Henrik B Rasmussen, Thomas Werg. Serotonin transporter: evolution and impact of polymorphic transcriptional regulation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 136B. issue 1. 2005-08-23. PMID:15858819. |
the serotonin transporter (sert) is the primary drug target in the current antidepressant therapy. |
2005-08-23 |
2023-08-12 |
monkey |
| Karen Søeby, Svend A Larsen, Line Olsen, Henrik B Rasmussen, Thomas Werg. Serotonin transporter: evolution and impact of polymorphic transcriptional regulation. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 136B. issue 1. 2005-08-23. PMID:15858819. |
a functional polymorphism in the 2nd intron of the 5htt gene encoding the sert has been identified and associated with susceptibility to affective disorders and treatment response to antidepressants. |
2005-08-23 |
2023-08-12 |
monkey |
| Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. Journal of medicinal chemistry. vol 48. issue 13. 2005-08-23. PMID:15974579. |
a series of n,n-dimethylated and n-monomethylated analogues of n,n-dimethyl-2-(2'-amino-4'-iodophenylthio)benzylamine substituted at the 4'-phenyl position have been prepared and evaluated in vitro for serotonin transporter (sert) selectivity. |
2005-08-23 |
2023-08-12 |
human |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033275. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]-5-ht, and [(3)h]ne, respectively. |
2005-08-23 |
2023-08-12 |
Not clear |
| Brett C Ginsburg, Heather L Kimmel, F Ivy Carroll, Mark M Goodman, Leonard L Howel. Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys. Pharmacology, biochemistry, and behavior. vol 80. issue 3. 2005-08-16. PMID:15740791. |
among the drugs characterized, rti-112 is reportedly the least selective for binding to dat, net, and serotonin transporters (sert). |
2005-08-16 |
2023-08-12 |
human |
| Michael D Gersho. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. Journal of clinical gastroenterology. vol 39. issue 5 Suppl 3. 2005-08-11. PMID:15798484. |
serotonergic signaling in the mucosa and the ens is terminated by a transmembrane 5-ht transporter, sert. |
2005-08-11 |
2023-08-12 |
mouse |
| Michael D Gersho. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. Journal of clinical gastroenterology. vol 39. issue 5 Suppl 3. 2005-08-11. PMID:15798484. |
potentiation of 5-ht due to the sert decrease could account for the discomfort and diarrhea of ibs-d, while receptor desensitization may cause constipation. |
2005-08-11 |
2023-08-12 |
mouse |
| Andrew B Newberg, Jay D Amsterdam, Nancy Wintering, Karl Ploessl, Randel L Swanson, Justine Shults, Abass Alav. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 46. issue 6. 2005-08-09. PMID:15937308. |
few imaging studies have examined serotonin transporter (sert) binding in patients with mdd. |
2005-08-09 |
2023-08-12 |
Not clear |
| Per Plenge, Ove Wibor. High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15955412. |
the serotonin transporter (sert) is responsible for terminating or modulating the action of serotonin released from the presynaptic neuron and is the major target for most antidepressants including the tricyclic antidepressants and the selective serotonin uptake inhibitors. |
2005-08-09 |
2023-08-12 |
human |
| Per Plenge, Ove Wibor. High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15955412. |
two binding sites for uptake inhibitors and serotonin (5-ht) have been found on sert. |
2005-08-09 |
2023-08-12 |
human |
| Per Plenge, Ove Wibor. High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15955412. |
at one site, uptake inhibitors bind with high-affinity to sert, thereby blocking the uptake of 5-ht. |
2005-08-09 |
2023-08-12 |
human |
| Pirjo Irmeli Saarinen, Johannes Lehtonen, Mikko Joensuu, Tommi Tolmunen, Pasi Ahola, Ritva Vanninen, Jyrki Kuikka, Jari Tiihone. An outcome of psychodynamic psychotherapy: a case study of the change in serotonin transporter binding and the activation of the dream screen. American journal of psychotherapy. vol 59. issue 1. 2005-08-08. PMID:15895769. |
we explored the outcome of psychodynamic psychotherapy of a female patient with major depression using clinical evaluation and serotonin transporter (sert) binding assessed with [123i]nor-beta-cit spect. |
2005-08-08 |
2023-08-12 |
Not clear |
| W Gordon Frankle, Rajesh Narendran, Yiyun Huang, Dah-Ren Hwang, Ilise Lombardo, Claudine Cangiano, Roberto Gil, Marc Laruelle, Anissa Abi-Dargha. Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB. Biological psychiatry. vol 57. issue 12. 2005-08-02. PMID:15953487. |
postmortem studies have reported several alterations in serotonin transporter (sert) binding parameters in patients with schizophrenia. |
2005-08-02 |
2023-08-12 |
human |
| G Zalsman, G M Anderson, M Peskin, A Frisch, R A King, M Vekslerchik, E Sommerfeld, E Michaelovsky, L Sher, A Weizman, A Apte. Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 2. 2005-07-29. PMID:15657646. |
relationships between the serotonin transporter promoter polymorphism (5-httlpr), platelet serotonin transporter (sert) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal ashkenazi israeli adolescent psychiatric inpatients. |
2005-07-29 |
2023-08-12 |
Not clear |
| Devadoss J Samuvel, Lankupalle D Jayanthi, Narayan R Bhat, Sammanda Ramamoorth. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 1. 2005-07-20. PMID:15634764. |
the serotonin transporter (sert) is regulated by various signaling mechanisms that may operate to maintain appropriate levels of synaptic serotonin (5-ht). |
2005-07-20 |
2023-08-12 |
human |
| Devadoss J Samuvel, Lankupalle D Jayanthi, Narayan R Bhat, Sammanda Ramamoorth. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 1. 2005-07-20. PMID:15634764. |
cotransfection of hek-293 cells with sert and a constitutively active form of map kinase kinase 3b(e) [mkk3b(e)] increased 5-ht transport, and rna interference targeted to p38 mapk inhibited 5-ht uptake, confirming the involvement of active p38 mapk in sert expression. |
2005-07-20 |
2023-08-12 |
human |