| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
in this study, mice with constitutive reductions in the serotonin transporter (sert) or bdnf were investigated to further assess the functional relationship between serotonin neurotransmission and bdnf expression. |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
these data illustrate that a 50% decrease in bdnf does not appear to be sufficient to cause measurable changes in basal extracellular 5-ht concentrations and, furthermore, that constitutive reductions in sert expression are not associated with altered bdnf protein levels at the ages and in the brain regions examined in this study. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
many therapeutic and illicit drugs that modulate these functions act at the serotonin transporter (sert), thus a mouse model with reduced transporter expression was created to further investigate the effects of differential serotonin reuptake. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
in the present study, in vivo microdialysis was used to determine homeostatic alterations in extracellular 5-ht levels in unanesthetized sert knockout mice. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
sert(-/-) mice had significantly higher levels of basal dialysate 5-ht than sert(+/+) mice in striatum and frontal cortex. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
using this method, a gene dose-dependent increase in extraneuronal 5-ht was observed in striatum (2.8 +/- 1, 9.4 +/- 1 and 18 +/- 3 nm) and frontal cortex (1.4 +/- 0.4, 3.5 +/- 0.9 and 14 +/- 1 nm) in sert(+/+), sert(+/-) and sert(-/-) mice, respectively. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
potassium stimulation revealed greater depolarization-induced increases in striatal 5-ht but not dopamine in sert(-/-) mice. |
2005-04-12 |
2023-08-12 |
mouse |
| Tiffany A Mathews, Denise E Fedele, Francesca M Coppelli, Amy M Avila, Dennis L Murphy, Anne M Andrew. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589347. |
overall, these results demonstrate that constitutive reductions in sert are associated with increases in 5-ht in the extracellular signaling space in the absence of changes in dopamine neurochemistry. |
2005-04-12 |
2023-08-12 |
mouse |
| A K Larsen, L T Brennum, J Egebjerg, C Sánchez, C Halldin, P H Anderse. Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects. British journal of pharmacology. vol 141. issue 6. 2005-04-11. PMID:14993096. |
binding of the novel radioligand (3)h-2-(2-dimethylaminomethyl-phenylsulphanyl)-5-methyl-phenylamine ((3)h-madam) to the serotonin transporter (sert) was used to characterise a range of selective serotonin re-uptake inhibitors (ssris) in vitro and in vivo. |
2005-04-11 |
2023-08-12 |
mouse |
| Michael J Owens, Jerrold F Rosenbau. Escitalopram: a second-generation SSRI. CNS spectrums. vol 7. issue 4 Suppl 1. 2005-04-04. PMID:15131491. |
furthermore, all drugs known to be selective (a relative term) serotonin transporter (sert) inhibitors are effective antidepressants. |
2005-04-04 |
2023-08-12 |
Not clear |
| Chong-Bin Zhu, William A Hewlett, Sharron H Francis, Jackie D Corbin, Randy D Blakel. Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. European journal of pharmacology. vol 504. issue 1-2. 2005-03-23. PMID:15507214. |
the serotonin (5-hydroxtryptamine, 5-ht) transporter (sert) plays a critical role in the inactivation of synaptic 5-ht and has been implicated in multiple psychiatric and peripheral disorders. |
2005-03-23 |
2023-08-12 |
Not clear |
| Chong-Bin Zhu, William A Hewlett, Sharron H Francis, Jackie D Corbin, Randy D Blakel. Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. European journal of pharmacology. vol 504. issue 1-2. 2005-03-23. PMID:15507214. |
sildenafil stimulation of 5-ht uptake arises from an increase in 5-ht transport vmax and is paralleled by elevated sert surface antagonist binding, also h8-sensitive. |
2005-03-23 |
2023-08-12 |
Not clear |
| Xuemei Peng, Ao Zhang, Nora S Kula, Ross J Baldessarini, John L Neumeye. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorganic & medicinal chemistry letters. vol 14. issue 22. 2005-03-22. PMID:15482938. |
novel compounds were evaluated for affinity and selectivity in competitive radioligand binding assays selective for cerebral serotonin (5-ht), dopamine (da), and norepinephrine (ne) transporters (sert, dat, and net). |
2005-03-22 |
2023-08-12 |
Not clear |
| M L Rudd, A N Nicolas, B L Brown, K Fischer-Stenger, J K Stewar. Peritoneal macrophages express the serotonin transporter. Journal of neuroimmunology. vol 159. issue 1-2. 2005-03-18. PMID:15652409. |
in this study, mrna coding for the serotonin transporter (sert) was detected with the reverse transcription-polymerase chain reaction (rt-pcr) in recruited mouse peritoneal macrophages. |
2005-03-18 |
2023-08-12 |
mouse |
| Nina Koldzic-Zivanovic, Patricia K Seitz, Cheryl S Watson, Kathryn A Cunningham, Mary L Thoma. Intracellular signaling involved in estrogen regulation of serotonin reuptake. Molecular and cellular endocrinology. vol 226. issue 1-2. 2005-03-17. PMID:15489003. |
rn46a cells express the serotonin transporter (sert) and estrogen receptor (er)beta, but not eralpha. |
2005-03-17 |
2023-08-12 |
rat |
| Matthew S Milak, R Todd Ogden, Daniel N Vinocur, Ronald L Van Heertum, Thomas B Cooper, J John Mann, Ramin V Parse. Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency. Biological psychiatry. vol 57. issue 1. 2005-03-14. PMID:15607307. |
the objective of this study was to evaluate the sensitivity of [(11)c]-n,n-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine (dasb) binding to the brain serotonin transporter (sert) to changes in endogenous serotonin (5-hydroxytryptamine [5-ht]) levels. |
2005-03-14 |
2023-08-12 |
Not clear |
| Matthew S Milak, R Todd Ogden, Daniel N Vinocur, Ronald L Van Heertum, Thomas B Cooper, J John Mann, Ramin V Parse. Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency. Biological psychiatry. vol 57. issue 1. 2005-03-14. PMID:15607307. |
a ligand insensitive to ec can provide a measure of sert unaffected by levels of 5-ht. |
2005-03-14 |
2023-08-12 |
Not clear |
| Matthew S Milak, R Todd Ogden, Daniel N Vinocur, Ronald L Van Heertum, Thomas B Cooper, J John Mann, Ramin V Parse. Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency. Biological psychiatry. vol 57. issue 1. 2005-03-14. PMID:15607307. |
alternatively, serotonin depletion could accelerate internalization of sert and reduce binding. |
2005-03-14 |
2023-08-12 |
Not clear |
| Tetsurou Ikeda, Masaru Kurosawa, Chiharu Uchikawa, Shigeo Kitayama, Nobuyuki Nukin. Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629452. |
down-regulation of serotonin transporter (sert) mrna levels and the subsequent decrease in serotonin uptake and binding were observed after chronic rtms. |
2005-03-11 |
2023-08-12 |
mouse |
| Hideki Mochizuki, Taku Amano, Takahiro Seki, Hiroaki Matsubayashi, Chieko Mitsuhata, Katsuya Morita, Shigeo Kitayama, Toshihiro Dohi, Hiromu K Mishima, Norio Saka. Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT). Neurochemistry international. vol 46. issue 2. 2005-03-09. PMID:15627510. |
role of c-terminal region in the functional regulation of rat serotonin transporter (sert). |
2005-03-09 |
2023-08-12 |
rat |