| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberto Perrone, Francesco Berardi, Nicola A Colabufo, Enza Lacivita, Carmela Larizza, Marcello Leopoldo, Vincenzo Tortorell. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. The Journal of pharmacy and pharmacology. vol 57. issue 10. 2006-04-18. PMID:16259761. |
among the compounds studied, 2-[4-(2-methoxyphenyl)piperazin-1-yl]-n-(6-nitro-2-quinolyl)ethylamine (21) and 1-(5-bromo-1,2,3,4-tetrahydronaphthalen-1-yl)-3-[4-(2-methoxyphenyl)-piperazin-1-yl]-1-propanone (24) showed good affinity values for sert and 5-ht(1a) receptors (sert: k(i) (inhibition constant)=71.8 and 62.8 nm; 5-ht(1a)k(i)=14.2 and 0.82 nm, respectively). |
2006-04-18 |
2023-08-12 |
Not clear |
| Kjell Erlandsson, Tharani Sivananthan, Dominic Lui, Andrea Spezzi, Caroline E Townsend, Song Mu, Richard Lucas, Steven Warrington, Peter J El. Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study. European journal of nuclear medicine and molecular imaging. vol 32. issue 11. 2006-04-17. PMID:16133377. |
[123i]adam is a novel spect tracer which binds with high affinity to serotonin transporters (sert). |
2006-04-17 |
2023-08-12 |
Not clear |
| Mads Breum Larsen, Anja Winther Fjorback, Ove Wibor. The C-terminus is critical for the functional expression of the human serotonin transporter. Biochemistry. vol 45. issue 4. 2006-04-14. PMID:16430230. |
the plasma membrane serotonin transporter (sert) has an important role in terminating serotonergic neurotransmission by re-uptake of 5-ht from the synaptic cleft. |
2006-04-14 |
2023-08-12 |
human |
| Kellie J White, Crystal C Walline, Eric L Barke. Serotonin transporters: implications for antidepressant drug development. The AAPS journal. vol 7. issue 2. 2006-04-06. PMID:16353921. |
therefore, the serotonin transporter (sert) has become a pharmacological target for treating these symptoms. |
2006-04-06 |
2023-08-12 |
Not clear |
| Yuhong Wang, Rie Takai, Hidekatsu Yoshioka, Komei Shirab. Characterization and expression of serotonin transporter genes in zebrafish. The Tohoku journal of experimental medicine. vol 208. issue 3. 2006-04-06. PMID:16498236. |
in this study we cloned two cdnas (complementary dnas) coding for serotonin transporter (sert) from the zebrafish, named serta and sertb. |
2006-04-06 |
2023-08-12 |
human |
| Jonathan Cavanagh, James Patterson, Sally Pimlott, Deborah Dewar, Jos Eersels, Mary Frances Dempsey, David Wype. Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological psychiatry. vol 59. issue 4. 2006-04-04. PMID:16197922. |
serotonin transporters (sert) are a major target for antidepressant medication, although there have been limited in vivo studies of sert availability in patients being treated with antidepressants. |
2006-04-04 |
2023-08-12 |
Not clear |
| Markus Storvik, Jari Tiihonen, Tuija Haukijärvi, Erkki Tupal. Lower serotonin transporter binding in caudate in alcoholics. Synapse (New York, N.Y.). vol 59. issue 3. 2006-04-04. PMID:16358330. |
in this study, possible alterations of [(3)h]citalopram binding to serotonin transporter (sert) were evaluated in the dorsal striatum of cloninger type 1 and 2 alcoholics, and nonalcoholic control subjects by postmortem whole-hemisphere autoradiography in humans. |
2006-04-04 |
2023-08-12 |
human |
| Christophe Plisson, Nachwa Jarkas, Jon McConathy, Ronald J Voll, John Votaw, Larry Williams, Leonard L Howell, Clinton D Kilts, Mark M Goodma. Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET. Journal of medicinal chemistry. vol 49. issue 3. 2006-03-29. PMID:16451060. |
the nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((z)-2-iodoethenyl)phenyl]nortropane (zient), is a high affinity, selective serotonin transporter (sert) ligand that has shown promise as a sert imaging agent for single photon computed tomography (spect) when labeled with i-123. |
2006-03-29 |
2023-08-12 |
monkey |
| Johnny Vercouillie, Sylvie Mavel, Laurent Galineau, Tiziana Ragusa, Robert Innis, Michael Kassiou, Sylvie Chalon, Frédéric Dollé, Jean-Claude Besnard, Denis Guilloteau, Patrick Emon. Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands. Bioorganic & medicinal chemistry letters. vol 16. issue 5. 2006-03-23. PMID:16337793. |
as the serotonin transporter (sert) is involved in several neurodegenerative and psychiatric disorders, radiopharmaceuticals to image the sert by pet or spect would be very valuable in studying these diseases. |
2006-03-23 |
2023-08-12 |
Not clear |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes. Bioorganic & medicinal chemistry letters. vol 16. issue 1. 2006-03-21. PMID:16236497. |
most of the compounds exhibited nanomolar affinity for the serotonin transporter (sert). |
2006-03-21 |
2023-08-12 |
Not clear |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
to evaluate the consequences of inactivation of the serotonin transporter (sert) gene on 5-ht homeostasis and function, 5-ht synthesis and turnover rates were measured using the decarboxylase inhibition method in multiple brain regions (frontal cortex, striatum, brainstem, hippocampus and hypothalamus) from mice with a genetic disruption of sert. |
2006-03-10 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
5-ht synthesis rates were increased 30-60% in the different brain regions of sert -/- mice compared to littermate +/+ control mice despite 55-70% reductions in tissue 5-ht concentrations. |
2006-03-10 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
female sert -/- mice had greater increases (79%) in brain 5-ht synthesis than male -/- mice did (25%), a finding associated with higher brain tryptophan concentrations in females. |
2006-03-10 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
taken together, the results demonstrate a markedly altered homeostatic situation in sert -/- mice that lack 5-ht reuptake, resulting in markedly depleted tissue stores that are inadequately compensated for by increased 5-ht synthesis, with brain region and gender specificity observed. |
2006-03-10 |
2023-08-12 |
mouse |
| Birgit Hilber, Petra Scholze, Mario M Dorostkar, Walter Sandtner, Marion Holy, Stefan Boehm, Ernst A Singer, Harald H Sitt. Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16185723. |
the physiological function of neurotransmitter transporter proteins like the serotonin transporter (sert) is reuptake of neurotransmitter that terminates synaptic serotoninergic transmission. |
2006-03-10 |
2023-08-12 |
Not clear |
| Birgit Hilber, Petra Scholze, Mario M Dorostkar, Walter Sandtner, Marion Holy, Stefan Boehm, Ernst A Singer, Harald H Sitt. Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16185723. |
sert can operate in reverse direction and be induced by sert substrates including 5-ht, tyramine and the positively charged methyl-phenylpyridinium (mpp(+)), as well as the amphetamine derivatives para-chloroamphetamine (pca) and methylene-dioxy-methamphetamine (mdma). |
2006-03-10 |
2023-08-12 |
Not clear |
| L Keith Henry, Julie R Field, Erika M Adkins, M Laura Parnas, Roxanne A Vaughan, Mu-Fa Zou, Amy H Newman, Randy D Blakel. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. The Journal of biological chemistry. vol 281. issue 4. 2006-03-07. PMID:16272152. |
in previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters (serts), we identified tyr-95 in transmembrane segment 1 (tm1) of human sert as a major determinant of binding for several antagonists, including racemic citalopram ((rs)-cit). |
2006-03-07 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
defects in serotonergic transmission, including serotonin transporter (sert) function, have been implicated in depression, anxiety disorders and some aspects of schizophrenia. |
2006-03-07 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
the aim of the present study was to examine the effect of a low estrogen state in mice on the behavioral effect of drugs acting through the sert, serotonin uptake kinetics and sert density in the hippocampus. |
2006-03-07 |
2023-08-12 |
mouse |