| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaista Hayat, Robert J Williams, Marcus Rattra. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510483. |
we produced two cos-7 cell lines with different levels of expression of recombinant rat sert, as determined by 5-ht uptake assays, and compared them to human sert expressing jar cells and to untransfected cos-7 cells which do not express sert. |
2006-08-09 |
2023-08-12 |
human |
| Shaista Hayat, Robert J Williams, Marcus Rattra. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510483. |
cytotoxicity caused by 48 h exposure to 1 mm mdma at 37 degrees c was not related to the level of sert expression, not blocked by the sert-blocking drugs paroxetine or fluoxetine and not enhanced, in jar cells, by forskolin preincubation that increased 5-ht uptake capacity by 50%. |
2006-08-09 |
2023-08-12 |
human |
| M D Coates, A C Johnson, B Greenwood-Van Meerveld, G M Maw. Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 18. issue 6. 2006-08-04. PMID:16700726. |
serotonin-selective reuptake transporter (sert) expression is decreased in animal models of intestinal inflammation and in individuals with inflammatory bowel disease (ibd) or irritable bowel syndrome (ibs), and it is possible that resultant changes in intestinal serotonin signalling contribute to the manifestation of clinical features associated with these disorders. |
2006-08-04 |
2023-08-12 |
mouse |
| Dawn D Han, Howard H G. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC pharmacology. vol 6. 2006-08-03. PMID:16515684. |
the transporters for the monoamines dopamine, norepinephrine, and serotonin (dat, net, and sert) are targets for several popular psychostimulant drugs of abuse. |
2006-08-03 |
2023-08-12 |
mouse |
| Donatella Marazziti, Stefano Baroni, Laura Fabbrini, Paola Italiani, Mario Catena, Bernardo Dell'Osso, Laura Betti, Gino Giannaccini, Antonio Lucacchini, Giovanni B Cassan. Binding of 3H-WIN-35,428 and 125I-RTI-121 to human platelet membranes. Neurochemical research. vol 31. issue 3. 2006-07-20. PMID:16733812. |
the results showed that the binding of 3h-win-35,428 was too low to enable the detection of any structure; the binding of 125i-rti-121, on the other hand, revealed the presence of two binding sites with pharmacological profiles similar to that of the serotonin transporter (sert). |
2006-07-20 |
2023-08-12 |
human |
| Vladimir M Korkhov, Marion Holy, Michael Freissmuth, Harald H Sitt. The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16527819. |
here, we focused on glu136 of the serotonin transporter (sert); this residue is conserved in transmembrane domain 2 of neurotransmitter/sodium symporters and related proteins. |
2006-07-18 |
2023-08-12 |
Not clear |
| A J Thomas, M Hendriksen, M Piggott, I N Ferrier, E Perry, P Ince, J T O'Brie. A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. Neuropathology and applied neurobiology. vol 32. issue 3. 2006-07-05. PMID:16640648. |
previous studies investigating the serotonin transporter (sert) in depression have been inconsistent and included a large proportion of subjects who had committed suicide. |
2006-07-05 |
2023-08-12 |
human |
| W Gordon Frankle, Mark Slifstein, Roger N Gunn, Yiyun Huang, Dah-Ren Hwang, E Ashlie Darr, Rajesh Narendran, Anissa Abi-Dargham, Marc Laruell. Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 5. 2006-07-05. PMID:16644752. |
the aim of the present study was to define the optimal analytic method to derive accurate and reliable serotonin transporter (sert) receptor parameters with (11)c-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11)c-dasb). |
2006-07-05 |
2023-08-12 |
Not clear |
| Jennifer R O'Hara, Andrew C Skinn, Wallace K MacNaughton, Philip M Sherman, Keith A Sharke. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cellular microbiology. vol 8. issue 4. 2006-06-30. PMID:16548890. |
enteroendocrine cells, serotonin (5-ht) reuptake transporter (sert), 5-ht release, and inducible nitric oxide synthase (inos) expression were assessed in the colon of infected wild-type or severe combined immunodeficient (scid) mice. |
2006-06-30 |
2023-08-12 |
mouse |
| Jennifer R O'Hara, Andrew C Skinn, Wallace K MacNaughton, Philip M Sherman, Keith A Sharke. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cellular microbiology. vol 8. issue 4. 2006-06-30. PMID:16548890. |
5-ht and somatostatin enteroendocrine cells and sert were significantly reduced 10 days after infection, with numbers returning to control values at 30 days. |
2006-06-30 |
2023-08-12 |
mouse |
| Jennifer R O'Hara, Andrew C Skinn, Wallace K MacNaughton, Philip M Sherman, Keith A Sharke. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cellular microbiology. vol 8. issue 4. 2006-06-30. PMID:16548890. |
the host's immune response underlies changes to enteroendocrine cells, sert expression and 5-ht release in c. rodentium infection. |
2006-06-30 |
2023-08-12 |
mouse |
| Tammy L Awtry, Julie G Frank, Linda L Werlin. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). vol 59. issue 6. 2006-06-28. PMID:16463401. |
we investigated the effect of in vitro exposure to nicotinic acetylcholine receptors (nachrs), agonists, antagonists, and protein kinase a (pka) modulators on the activity of the serotonin transporter (sert) in prefrontocortical (pfc) synaptosomes. |
2006-06-28 |
2023-08-12 |
rat |
| Tammy L Awtry, Julie G Frank, Linda L Werlin. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). vol 59. issue 6. 2006-06-28. PMID:16463401. |
the plasma membrane sert is an active transport mechanism specific for serotonin. |
2006-06-28 |
2023-08-12 |
rat |
| Tammy L Awtry, Julie G Frank, Linda L Werlin. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). vol 59. issue 6. 2006-06-28. PMID:16463401. |
our data suggest that activation of nachrs, quite likely via pka, increase the activity of the sert in the pfc and, thereby, can alter 5-ht levels in a region important in the behavioral effects of nicotine and 5-ht. |
2006-06-28 |
2023-08-12 |
rat |
| Tammy L Awtry, Julie G Frank, Linda L Werlin. In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats. Synapse (New York, N.Y.). vol 59. issue 6. 2006-06-28. PMID:16463401. |
because the nachr antagonists mecamylamine and dihydro-beta-erythrodine (dhbetae) both decreased [(3)h]5-ht uptake into synaptosomes, it appeared that the sert might be tonically activated by acetylcholine present within our synaptosomal preparations. |
2006-06-28 |
2023-08-12 |
rat |
| William R Corbin, Kim Fromme, Susan E Bergeso. Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior. Journal of studies on alcohol. vol 67. issue 1. 2006-06-28. PMID:16536124. |
the current pilot study evaluated relations among serotonin transporter (sert) genotype, subjective alcohol responses, and drinking behavior across both the ascending and descending limbs of the blood alcohol curve. |
2006-06-28 |
2023-08-12 |
Not clear |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & medicinal chemistry letters. vol 15. issue 24. 2006-06-27. PMID:16213721. |
a series of n-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (dat), serotonin (sert), norepinephrine (net) transporters, and muscarinic m1 receptors. |
2006-06-27 |
2023-08-12 |
Not clear |
| Ralph Buchert, Rainer Thomasius, Kay Petersen, Florian Wilke, Jost Obrocki, Bruno Nebeling, Lutz Wartberg, Pavlina Zapletalova, Malte Clause. Reversibility of ecstasy-induced reduction in serotonin transporter availability in polydrug ecstasy users. European journal of nuclear medicine and molecular imaging. vol 33. issue 2. 2006-06-22. PMID:16133393. |
previously we reported protracted reductions in the availability of the serotonin transporter (sert), an index of integrity of the axon terminals of brain serotonergic neurons, in sert-rich brain regions in current human ecstasy users. |
2006-06-22 |
2023-08-12 |
human |
| Henrik Amtoft Neubauer, Carsten Gram Hansen, Ove Wibor. Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. Molecular pharmacology. vol 69. issue 4. 2006-06-19. PMID:16434615. |
the serotonin transporter (sert), which belongs to a family of sodium/chloride-dependent transporters, is the major pharmacological target in the treatment of several clinical disorders, including depression and anxiety. |
2006-06-19 |
2023-08-12 |
human |
| Henrik Amtoft Neubauer, Carsten Gram Hansen, Ove Wibor. Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. Molecular pharmacology. vol 69. issue 4. 2006-06-19. PMID:16434615. |
serotonin (5-hydroxytryptamine) and certain sert inhibitors possess affinity for both sites. |
2006-06-19 |
2023-08-12 |
human |