| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henrik Amtoft Neubauer, Carsten Gram Hansen, Ove Wibor. Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. Molecular pharmacology. vol 69. issue 4. 2006-06-19. PMID:16434615. |
the finding of an allosteric mechanism at sert is likely to be of physiological importance, in that serotonin was also found to act as an allosteric effector at duloxetine, rti-55 and (s)-citalopram. |
2006-06-19 |
2023-08-12 |
human |
| Jörg Zessin, Winnie Deuther-Conrad, Marion Kretzschmar, Frank Wüst, Beate Pawelke, Peter Brust, Jörg Steinbach, Ralf Bergman. [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats. Nuclear medicine and biology. vol 33. issue 1. 2006-06-19. PMID:16459259. |
n,n-dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (sme-adam, 1) is a highly potent and selective inhibitor of the serotonin transporter (sert). |
2006-06-19 |
2023-08-12 |
rat |
| Brian J Piper, Huyen L Vu, Mina G Safain, Andrew J Oliver, Jerrold S Meye. Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16434566. |
adolescent mdma exposure partially attenuated the hyperthermic effects of the pd 67 mdma challenge, completely blocked the locomotor hypoactivity otherwise observed on the day after the challenge, and also prevented mdma-induced serotonin neurotoxicity assessed on pd 74 by measuring regional [(3)h]citalopram binding to the serotonin transporter (sert). |
2006-06-09 |
2023-08-12 |
rat |
| Howard H Gu, Xiaohong Wu, Dawn D Ha. Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding. Biochemical and biophysical research communications. vol 343. issue 4. 2006-06-09. PMID:16580636. |
serotonin transporter (sert) is one of the key protein targets of cocaine. |
2006-06-09 |
2023-08-12 |
drosophila_melanogaster |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
the serotonin transporter (sert) protein, on the other hand, is less liable to metabolism and for that reason we hypothetized that sert immunostaining is a more stable marker of serotonergic fibers. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
brains were double immunostained for serotonin and sert protein and colocalization was quantified in several brain areas by confocal microscopy. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
in comparison with untreated rats, mao inhibitor treated rats had a significantly higher number (almost 200% increase) of serotonin immunopositive fibers whereas no difference was observed in the number of the sert positive fibers. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
colocalization between serotonin and sert positive fibers was close to 100% in mao inhibitor treated animals but only 30% in untreated rats. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
we conclude that the rapid metabolism of serotonin leads to an underestimation of immunodetected serotonergic fibers and that in many instances, sert immunostaining may be a better indicator of serotonergic fibers. |
2006-05-25 |
2023-08-12 |
rat |
| Masanori Ichise, Douglass C Vines, Tami Gura, George M Anderson, Stephen J Suomi, J Dee Higley, Robert B Inni. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641244. |
this study compared regional brain serotonin transporter (sert) binding between nine pr and seven mother-reared rhesus monkeys with [11c]dasb positron emission tomography (pet) imaging. |
2006-05-23 |
2023-08-12 |
monkey |
| R Iceta, J E Mesonero, J J Aramayona, A I Alcald. Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 1. 2006-05-22. PMID:16601320. |
the serotonin transporter (sert) has shown itself to be an effective pharmacological target in the treatment of mood disorders and some kinds of gastrointestinal syndromes. |
2006-05-22 |
2023-08-12 |
human |
| Jeffrey L Rausch, Maria E Johnson, Junqing Li, Julian Hutcheson, Benjamin M Carr, Katina M Corley, Amanda B Gowans, Joseph Smit. Serotonin transport kinetics correlated between human platelets and brain synaptosomes. Psychopharmacology. vol 180. issue 3. 2006-05-16. PMID:15726335. |
blood platelets have been used extensively as a model system for investigating the role of the serotonin transporter (sert) in various psychiatric disorders, especially depression. |
2006-05-16 |
2023-08-12 |
human |
| Georgianna G Gould, Alfonso V Altamirano, Martin A Javors, Alan Fraze. A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16140280. |
venlafaxine blocks both serotonin and norepinephrine transporters (sert and net), with higher affinity for sert. |
2006-05-11 |
2023-08-12 |
rat |
| Georgianna G Gould, Alfonso V Altamirano, Martin A Javors, Alan Fraze. A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16140280. |
chronic treatment of rats with selective serotonin reuptake inhibitors decreases sert binding sites, whereas similar treatment with selective norepinephrine reuptake inhibitors decreases net binding sites. |
2006-05-11 |
2023-08-12 |
rat |
| Elisabeth Greiner, Terrence L Boos, Thomas E Prisinzano, Maria G De Martino, Brian Zeglis, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of medicinal chemistry. vol 49. issue 5. 2006-04-25. PMID:16509591. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-04-25 |
2023-08-12 |
Not clear |
| Luciano Minuzzi, Aage Kristian Olsen, Dirk Bender, Sidse Arnfred, Rebecca Grant, Erik H Danielsen, Paul Cummin. Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: comparison with results in vivo. Synapse (New York, N.Y.). vol 59. issue 4. 2006-04-21. PMID:16385509. |
whereas the tropane derivative [125i]rti-55 labeled serotonin transporters (serotonin transporter (sert)) in pig brain, use of the same ligand under conditions specific for dat, revealed a pattern of binding similar to that observed for sert conditions. |
2006-04-21 |
2023-08-12 |
human |
| Aina Westrheim Ravna, Ingebrigt Sylte, Kurt Kristiansen, Svein G Dah. Putative drug binding conformations of monoamine transporters. Bioorganic & medicinal chemistry. vol 14. issue 3. 2006-04-20. PMID:16216517. |
based on the hypothesis that the 12 transmembrane alpha-helix (tmh) secondary transporters belong to a common folding class, the lac permease structure was used for molecular modeling of the serotonin transporter (sert), the dopamine transporter (dat), and the noradrenaline transporter (net). |
2006-04-20 |
2023-08-12 |
Not clear |
| Roberto Perrone, Francesco Berardi, Nicola A Colabufo, Enza Lacivita, Carmela Larizza, Marcello Leopoldo, Vincenzo Tortorell. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. The Journal of pharmacy and pharmacology. vol 57. issue 10. 2006-04-18. PMID:16259761. |
design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (sert) and 5-ht(1a) receptor. |
2006-04-18 |
2023-08-12 |
Not clear |
| Roberto Perrone, Francesco Berardi, Nicola A Colabufo, Enza Lacivita, Carmela Larizza, Marcello Leopoldo, Vincenzo Tortorell. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. The Journal of pharmacy and pharmacology. vol 57. issue 10. 2006-04-18. PMID:16259761. |
a new generation of antidepressant agents could be represented by compounds with mixed activity as serotonin transporter (sert) inhibitors and 5-ht(1a) receptor antagonists. |
2006-04-18 |
2023-08-12 |
Not clear |
| Roberto Perrone, Francesco Berardi, Nicola A Colabufo, Enza Lacivita, Carmela Larizza, Marcello Leopoldo, Vincenzo Tortorell. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. The Journal of pharmacy and pharmacology. vol 57. issue 10. 2006-04-18. PMID:16259761. |
we report here on the synthesis and evaluation of sert and 5-ht(1a) receptor affinity of long-chain arylpiperazines obtained either by modifying 6-nitroquipazine into a long-chain arylpiperazine or by inserting a modified 6-nitroquipazine moiety or other structures endowed with sert affinity into a long-chain arylpiperazine with 5-ht(1a) affinity. |
2006-04-18 |
2023-08-12 |
Not clear |