| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-09-11 |
2023-08-12 |
Not clear |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
among the trisubstituted compounds, (-)-4b exhibited the highest potency for the net and the sert (k(i) of 2.13 and 15.3 nm, respectively) and was a serotonin norepinephrine reuptake inhibitor (snri). |
2006-09-11 |
2023-08-12 |
Not clear |
| Christophe Wersinger, Milan Rusnak, Anita Sidh. Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882008. |
given the considerable homology between dopamine transporters and the serotonin (5-ht) transporter (sert), we examined whether alpha-syn could similarly regulate sert function. |
2006-09-05 |
2023-08-12 |
human |
| Christophe Wersinger, Milan Rusnak, Anita Sidh. Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882008. |
increasing expression levels of human alpha-syn gradually decreased [(3)h]5-ht uptake by human sert in cotransfected ltk(-) cells, by diminishing its v(max) without changing its k(m), as compared to cells expressing only sert. |
2006-09-05 |
2023-08-12 |
human |
| Christophe Wersinger, Milan Rusnak, Anita Sidh. Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882008. |
the negative modulation of sert activity by alpha-syn occurred through the non-abeta-amyloid component (nac) domain of alpha-syn (aa58-107); dna constructs encoding this region mimicked the full-length alpha-syn protein by decreasing [(3)h]5-ht uptake by the transporter. |
2006-09-05 |
2023-08-12 |
human |
| Xiao Yu Tian, Zhao Xiang Bian, Xu Guang Hu, Xiao Jun Zhang, Liang Liu, Hongqi Zhan. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain research. vol 1088. issue 1. 2006-08-25. PMID:16650387. |
in addition, the effect of ea on 5-ht(4a) receptor and serotonin transporter (sert) expression in the colon mucosa was analyzed semi-quantitatively through immunohistochemistry and 5-ht concentration in the colon tissue was observed through spectro-photo-fluorimeter detection, respectively. |
2006-08-25 |
2023-08-12 |
rat |
| Xiao Yu Tian, Zhao Xiang Bian, Xu Guang Hu, Xiao Jun Zhang, Liang Liu, Hongqi Zhan. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain research. vol 1088. issue 1. 2006-08-25. PMID:16650387. |
furthermore, ea decreased 5-ht concentration in colon in rats with cvh and cvh rats with water avoidance stress, and increased the 5-ht(4a) and sert expression in rats with cvh. |
2006-08-25 |
2023-08-12 |
rat |
| Xiomara A Perez, Laura E Bianco, Anne M Andrew. Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chronoamperometry in SERT knockout mice. Journal of neuroscience methods. vol 154. issue 1-2. 2006-08-23. PMID:16472867. |
filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chronoamperometry in sert knockout mice. |
2006-08-23 |
2023-08-12 |
mouse |
| Xiomara A Perez, Laura E Bianco, Anne M Andrew. Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chronoamperometry in SERT knockout mice. Journal of neuroscience methods. vol 154. issue 1-2. 2006-08-23. PMID:16472867. |
radiochemical methods have failed to reveal decreases in synaptosomal serotonin uptake in mice lacking one functional copy of the serotonin transporter (sert) gene. |
2006-08-23 |
2023-08-12 |
mouse |
| Xiomara A Perez, Laura E Bianco, Anne M Andrew. Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chronoamperometry in SERT knockout mice. Journal of neuroscience methods. vol 154. issue 1-2. 2006-08-23. PMID:16472867. |
we revisited [(3)h]5-ht uptake in sert knockout mice to determine the effects of inclusion of o(2) in the incubation buffer on the kinetic parameters obtained by this method. |
2006-08-23 |
2023-08-12 |
mouse |
| Chee Hong Ng, Simon Easteal, Susan Tan, Isaac Schweitzer, Brian Kong Wai Ho, Salina Azi. Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 5. 2006-08-18. PMID:16580768. |
the aim of this pilot study was to examine the relationship between clinical response, adverse effects, sertraline (sert) plasma concentrations and the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5httlpr) in 2 ethnic patient groups. |
2006-08-18 |
2023-08-12 |
human |
| John L Musachio, Jinsoo Hong, Masanori Ichise, Nicholas Seneca, Amira K Brown, Jeih-San Liow, Christer Halldin, Robert B Innis, Victor W Pike, Rong He, Jia Zhou, Alan P Kozikowsk. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & medicinal chemistry letters. vol 16. issue 12. 2006-08-16. PMID:16621532. |
[11c]5 and [11c]6 display high affinity for the net in vitro (ki = 0.94 and 0.68 nm, respectively) and significant selectivity over the dopamine (dat) and serotonin transporters (sert). |
2006-08-16 |
2023-08-12 |
Not clear |
| Robert A Whittington, László Virá. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesthesia and analgesia. vol 103. issue 1. 2006-08-16. PMID:16790633. |
to determine if isoflurane-induced changes in extracellular 5-ht involve the serotonin transporter (sert), similar microdialysis studies were performed in c57bl/6 wild-type (sert +/+) and homozygous sert knockout (sert -/-) mice exposed to either 1 mac isoflurane in 40% o2 in air or to 40% o2 in air alone for a period of 80 min. |
2006-08-16 |
2023-08-12 |
mouse |
| Robert A Whittington, László Virá. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesthesia and analgesia. vol 103. issue 1. 2006-08-16. PMID:16790633. |
isoflurane produced a significant decrease in hippocampal 5-ht in sert +/+ and sert -/-, and this decrease was larger in sert -/- compared with sert +/+: to 22.4% +/- 8.5% versus 50.2% +/- 17.4% of the baseline 5-ht level, respectively. |
2006-08-16 |
2023-08-12 |
mouse |
| Robert A Whittington, László Virá. Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesthesia and analgesia. vol 103. issue 1. 2006-08-16. PMID:16790633. |
these data suggest that isoflurane produces a decrease in hippocampal 5-ht, independent of sert function. |
2006-08-16 |
2023-08-12 |
mouse |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16481172. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-08-14 |
2023-08-12 |
Not clear |
| Terrence L Boos, Elisabeth Greiner, W Jason Calhoun, Thomas E Prisinzano, Barbara Nightingale, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16563775. |
a series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the n-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined. |
2006-08-14 |
2023-08-12 |
Not clear |
| Liesbeth Reneman, Maartje M L de Win, Wim van den Brink, Jan Booij, Gerard J den Heete. Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510475. |
although pet and spect may be limited by several factors such as the low cortical uptake and the use of a non-optimal reference region (cerebellum) the few studies conducted so far provide suggestive evidence that people who heavily use ecstasy are at risk of developing subcortical, and probably also cortical reductions in serotonin transporter (sert) densities, a marker of 5-ht neurotoxicity. |
2006-08-09 |
2023-08-12 |
human |
| R Thomasius, P Zapletalova, K Petersen, R Buchert, B Andresen, L Wartberg, B Nebeling, A Schmold. Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510479. |
this longitudinal study investigated whether mood, cognition and central serotonin transporters (sert) would deteriorate with continued mdma use and whether or not they would recover over increasing periods of mdma abstinence. |
2006-08-09 |
2023-08-12 |
human |
| Shaista Hayat, Robert J Williams, Marcus Rattra. Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of psychopharmacology (Oxford, England). vol 20. issue 2. 2006-08-09. PMID:16510483. |
these in vivo studies show that an interaction between mdma and the serotonin transporter protein (sert) is the .rst step in toxicity. |
2006-08-09 |
2023-08-12 |
human |