| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wadad Saba, Héric Valette, Marie-Anne Schöllhorn-Peyronneau, Christine Coulon, Michele Ottaviani, Sylvie Chalon, Frédéric Dolle, Patrick Emond, Christer Halldin, Julie Helfenbein, Jean-Claude Madelmont, Jean-Bernard Deloye, Denis Guilloteau, Michel Bottlaende. [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068778. |
the serotonin transporter (sert) antagonist citalopram (5 mg/kg i.v.) |
2007-01-26 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Michael J Owens, John R Votaw, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154506. |
2beta-carbomethoxy-3beta-(3'-((z)-2-iodoethenyl)phenyl)nortropane (mzient, 1) and 2beta-carbomethoxy-3beta-(3'-((z)-2-bromoethenyl)phenyl)nortropane (mzbrent, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (sert, dat, and net, respectively) using transfected cells. |
2007-01-19 |
2023-08-12 |
human |
| Paul D Callaghan, Kirsten Farrand, Abdallah Salem, Patrick Hughes, Lynette C Daws, Rodney J Irvin. Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European journal of pharmacology. vol 546. issue 1-3. 2007-01-11. PMID:16925993. |
the aim of this study was to determine the effect of repeated pma administration on two indices of 5-ht axonal degeneration, cortical brain 5-ht transporter (sert) density and 5-ht/5-hydroxyindolacetic acid (5-hiaa) content. |
2007-01-11 |
2023-08-12 |
rat |
| Yukio Takamatsu, Hideko Yamamoto, Yasukazu Ogai, Yoko Hagino, Athina Markou, Kazutaka Iked. Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105925. |
interestingly, the rewarding effects of cocaine are retained in dopamine transporter (dat) knockout (ko) mice, while serotonin transporter (sert) and dat double ko mice do not exhibit conditioned place preference (cpp) to cocaine. |
2007-01-10 |
2023-08-12 |
mouse |
| Jerrold S Meyer, Matthew E Brevard, Brian J Piper, Syed F Ali, Craig F Ferri. Neural effects of MDMA as determined by functional magnetic resonance imaging and magnetic resonance spectroscopy in awake marmoset monkeys. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105934. |
in a second study, magnetic resonance spectroscopy (mrs) and postmortem measurements of serotonin transporter (sert) binding and serotonin (5-ht) concentrations were used to determine the neurotoxic effects of low (4 x 1 mg/kg p.o.) |
2007-01-10 |
2023-08-12 |
monkey |
| Jerrold S Meyer, Matthew E Brevard, Brian J Piper, Syed F Ali, Craig F Ferri. Neural effects of MDMA as determined by functional magnetic resonance imaging and magnetic resonance spectroscopy in awake marmoset monkeys. Annals of the New York Academy of Sciences. vol 1074. 2007-01-10. PMID:17105934. |
monkeys given the high-dose regimen also showed prolonged hyperthermia and reductions in 5-ht and sert in a number of brain areas. |
2007-01-10 |
2023-08-12 |
monkey |
| Yuan-Wei Zhang, Gary Rudnic. The cytoplasmic substrate permeation pathway of serotonin transporter. The Journal of biological chemistry. vol 281. issue 47. 2007-01-09. PMID:17008313. |
serotonin transporter (sert) catalyzes reuptake of the neurotransmitter serotonin (5-ht) and is a target for antidepressant drugs and psychostimulants. |
2007-01-09 |
2023-08-12 |
Not clear |
| Kathelijne Peremans, Ingeborg Goethals, Filip De Vos, A Dobbeleir, Hamphrey Ham, Henri Van Bree, Cees Van Heeringen, Kurt Audenaer. Serotonin transporter and dopamine transporter imaging in the canine brain. Nuclear medicine and biology. vol 33. issue 7. 2007-01-09. PMID:17045171. |
selective serotonin (5-ht) reuptake inhibitors (ssris) are designed to block the 5-ht transporter (sert), thereby increasing the available 5-ht in the brain. |
2007-01-09 |
2023-08-12 |
Not clear |
| Alessandro Serretti, Raffaella Calati, Laura Mandelli, Diana De Ronch. Serotonin transporter gene variants and behavior: a comprehensive review. Current drug targets. vol 7. issue 12. 2007-01-08. PMID:17168841. |
a key molecular structure of this system, the serotonin transporter (sert) gene, has been associated with many human behaviors, both normal and pathological. |
2007-01-08 |
2023-08-12 |
human |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
we studied in vivo expression of the serotonin transporter (sert) protein after 3,4-methylenedioxymethamphetamine (mdma), p-chloroamphetamine (pca), or fenfluramine (fen) treatments, and compared the effects of substituted amphetamines to those of 5,7-dihydroxytryptamine (5,7-dht), an established serotonin (5-ht) neurotoxin. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
all drug treatments produced lasting reductions in 5-ht, 5-hiaa, and [(3)h]paroxetine binding, but no significant change in the density of a 70 kda band initially thought to correspond to the sert protein. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
in the same animals, tryptophan hydroxylase (tph)-ir axon density was comparably reduced, indicating that serotonergic deficits after substituted amphetamines differ from those in sert-null animals, which have normal tph levels but, in the absence of sert, develop apparent neuroadaptive changes in 5-ht metabolism. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
together, these results suggest that lasting serotonergic deficits after mdma and related drugs are unlikely to represent neuroadaptive metabolic responses to changes in sert trafficking, and favor the view that substituted amphetamines have the potential to produce a distal axotomy of brain 5-ht neurons. |
2007-01-05 |
2023-08-12 |
Not clear |
| Yu-Shin Ding, Kuo-Shyan Lin, Jean Loga. PET imaging of norepinephrine transporters. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073682. |
the fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (dat, net and sert) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable net ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific cns disorders. |
2007-01-03 |
2023-08-12 |
Not clear |
| Zhong-Qiu Zhao, Michael Scott, Santina Chiechio, Jin-Shan Wang, Kenneth J Renner, Robert W Gereau, Randy L Johnson, Evan S Deneris, Zhou-Feng Che. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 49. 2006-12-29. PMID:17151281. |
the loss of gene expression is concomitant with downregulation of lmx1b expression, with the exception of serotonin transporter sert and tryptophan hydroxylase tph2, whose expression appears to be most sensitive to lmx1b. |
2006-12-29 |
2023-08-12 |
mouse |
| J M Park, M-G Choi, J-A Park, J H Oh, Y K Cho, I S Lee, S W Kim, K Y Choi, I-S Chun. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 18. issue 11. 2006-12-28. PMID:17040410. |
polymorphisms in the promoter region of the serotonin reuptake transporter (sert) gene may underlie the disturbance in gut function in patients with irritable bowel syndrome (ibs). |
2006-12-28 |
2023-08-12 |
human |
| Aina Westrheim Ravna, Malgorzata Jaronczyk, Ingebrigt Sylt. A homology model of SERT based on the LeuT(Aa) template. Bioorganic & medicinal chemistry letters. vol 16. issue 21. 2006-12-22. PMID:16919451. |
a human serotonin transporter (sert) model has been constructed based on the crystal structure of the bacterial homologue of na(+)/cl(-)-dependent neurotransmitter transporters from aquifex aeolicus (leut(aa)). |
2006-12-22 |
2023-08-12 |
human |
| Stefan Viktor Vormfelde, Imke Hoell, Mladen Tzvetkov, Katja Jamrozinski, Daniel Sehrt, Jürgen Brockmöller, Eric Leibin. Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms. Journal of psychiatric research. vol 40. issue 6. 2006-12-20. PMID:16313923. |
the affection of human personality by the promoter and the intron 2 polymorphism in the serotonin transporter gene (sert) is inconsistently reported. |
2006-12-20 |
2023-08-12 |
human |
| René Hummerich, Oliver Schulze, Thomas Rädler, Pal Mikecz, Matthias Reimold, Winfried Brenner, Malte Clausen, Patrick Schloss, Ralph Bucher. Inhibition of serotonin transport by (+)McN5652 is noncompetitive. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631080. |
imaging of the serotonergic innervation of the brain using positron emission tomography (pet) with the serotonin transporter (sert) ligand [11c] (+)mcn5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11c] (+)mcn5652 and serotonin at the sert. |
2006-12-18 |
2023-08-12 |
Not clear |
| René Hummerich, Oliver Schulze, Thomas Rädler, Pal Mikecz, Matthias Reimold, Winfried Brenner, Malte Clausen, Patrick Schloss, Ralph Bucher. Inhibition of serotonin transport by (+)McN5652 is noncompetitive. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631080. |
the aim of the present study therefore was to pharmacologically characterize the interaction of [11c] (+)mcn5652 and serotonin at the sert. |
2006-12-18 |
2023-08-12 |
Not clear |