| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N van Lelyveld, J Ter Linde, M E I Schipper, M Samso. Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19. issue 5. 2007-06-13. PMID:17509016. |
serotonin (5-ht)-positive cells were counted and the mrna levels of tryptophan hydroxylase (tph), serotonin transporter (sert), 5-ht(4) receptor and 5-ht(3) receptor subunits were quantified by real-time reverse transcription polymerase chain reaction. |
2007-06-13 |
2023-08-12 |
human |
| Una D McCann, Zsolt Szabo, Melin Vranesic, Esen Seckin, Gary Wand, Anna Duval, Robert F Dannals, George A Ricaurt. Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine. Molecular imaging and biology. vol 9. issue 3. 2007-06-11. PMID:17473958. |
this study used quantitative positron emission tomography (pet) with [(11)c] mcn5652, a serotonin transporter (sert) ligand to determine whether humans previously exposed to fenfluramines showed reductions in sert binding parameters. |
2007-06-11 |
2023-08-12 |
Not clear |
| Michael Decker, Jochen Lehman. Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters. Current topics in medicinal chemistry. vol 7. issue 4. 2007-06-07. PMID:17305576. |
selectivity profiles and affinities depend strongly on the length of the alkylene-spacer: for some dimeric inhibitors the norepinephrine transporter (net) and the dopamine transporter (dat) affinities changed gradually, but for the serotonin transporter (sert) a pentamethylene spacer showed the highest potency. |
2007-06-07 |
2023-08-12 |
Not clear |
| B Chanrion, C Mannoury la Cour, F Bertaso, M Lerner-Natoli, M Freissmuth, M J Millan, J Bockaert, P Mari. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17452640. |
using a proteomic approach, we identified several proteins that interact with the c terminus of the serotonin transporter (sert). |
2007-06-07 |
2023-08-12 |
mouse |
| B Chanrion, C Mannoury la Cour, F Bertaso, M Lerner-Natoli, M Freissmuth, M J Millan, J Bockaert, P Mari. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17452640. |
coexpression of nnos with sert in hek293 cells decreased sert cell surface localization and 5-hydroxytryptamine (5-ht) uptake. |
2007-06-07 |
2023-08-12 |
mouse |
| B Chanrion, C Mannoury la Cour, F Bertaso, M Lerner-Natoli, M Freissmuth, M J Millan, J Bockaert, P Mari. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17452640. |
these effects were absent in cells transfected with sert mutated in its pdz motif to prevent physical association with nnos, and 5-ht uptake was unaffected by activation or inhibition of nnos enzymatic activity. |
2007-06-07 |
2023-08-12 |
mouse |
| B Chanrion, C Mannoury la Cour, F Bertaso, M Lerner-Natoli, M Freissmuth, M J Millan, J Bockaert, P Mari. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17452640. |
reciprocally, indicating that 5-ht uptake stimulates nnos activity, no production was enhanced on exposure of cells cotransfected with nnos and sert to 5-ht. |
2007-06-07 |
2023-08-12 |
mouse |
| B Chanrion, C Mannoury la Cour, F Bertaso, M Lerner-Natoli, M Freissmuth, M J Millan, J Bockaert, P Mari. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17452640. |
this effect was abolished by 5-ht uptake inhibitors and absent in cells expressing sert mutated in its pdz motif. |
2007-06-07 |
2023-08-12 |
mouse |
| Yvonne Meier, Jyrki J Eloranta, Jutta Darimont, Manfred G Ismair, Christian Hiller, Michael Fried, Gerd A Kullak-Ublick, Stephan R Vavrick. Regional distribution of solute carrier mRNA expression along the human intestinal tract. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 4. 2007-06-06. PMID:17220238. |
the mrna expression levels of cnt1, cnt2, apical sodium-dependent bile acid transporter (abst), serotonin transporter (sert), pept1, and octn2 exhibit marked differences between different regions of the intestine: the first five are predominantly expressed in the small intestine, whereas octn2 exhibits strongest expression in the colon. |
2007-06-06 |
2023-08-12 |
human |
| Pinelopi Lundquist, Magnus Roman, Stina Syvänen, Per Hartvig, Gunnar Blomquist, Margareta Hammarlund-Udenaes, Bengt Långströ. Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats. Synapse (New York, N.Y.). vol 61. issue 6. 2007-06-01. PMID:17372973. |
the aim of this study was to investigate whether [(11)c]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([(11)c]dasb) binding to the plasma membrane serotonin transporter (sert) in the rhesus monkey and rat brain decreased after a pharmacologically-induced increase in the interstitial serotonin (5ht) concentration. |
2007-06-01 |
2023-08-12 |
rat |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
5-meo-dipt failed to stimulate reverse transport of [3h]5-ht through sert, while it prevented the releasing action of methamphetamine. |
2007-06-01 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
cellular protein kinases, phosphatases, and other serotonin transporter (sert) interacting proteins participate in several signaling mechanisms regulating sert activity. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
when added to cho-1 cells expressing sert, 8-bromo-cgmp stimulated 5-ht transport and sert phosphorylation. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
mutation of sert threonine 276 to alanine completely abolished cgmp-mediated stimulation of 5-ht transport and sert phosphorylation. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
although the t276a mutation had no significant effect on 5-ht transport or sert protein expression, mutation to aspartate (t276d) increased the level of 5-ht uptake to that of cgmp-stimulated 5-ht uptake in wild-type sert-expressing cells and was no longer sensitive to cgmp. |
2007-05-31 |
2023-08-12 |
rat |
| Markus Storvik, Jari Tiihonen, Tuija Haukijärvi, Erkki Tupal. Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography. Alcohol (Fayetteville, N.Y.). vol 40. issue 3. 2007-05-24. PMID:17418697. |
in this preliminary study, possible alterations of [3h]citalopram binding to serotonin transporter (sert) were evaluated in the nac of cloninger type 1 and 2 alcoholics (nine and seven subjects, respectively), and nonalcoholic controls (10 subjects) by human postmortem whole-hemisphere autoradiography. |
2007-05-24 |
2023-08-12 |
human |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| G Rudnic. Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722230. |
serotonin transporter (sert) serves the important function of taking up serotonin (5-ht) released during serotonergic neurotransmission. |
2007-05-23 |
2023-08-12 |
Not clear |
| G Rudnic. Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722230. |
sert catalyzes the influx of 5-ht together with na+ and cl- in a 1:1:1 stoichiometry. |
2007-05-23 |
2023-08-12 |
Not clear |