| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
5-meo-dipt failed to stimulate reverse transport of [3h]5-ht through sert, while it prevented the releasing action of methamphetamine. |
2007-06-01 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
cellular protein kinases, phosphatases, and other serotonin transporter (sert) interacting proteins participate in several signaling mechanisms regulating sert activity. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
when added to cho-1 cells expressing sert, 8-bromo-cgmp stimulated 5-ht transport and sert phosphorylation. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
mutation of sert threonine 276 to alanine completely abolished cgmp-mediated stimulation of 5-ht transport and sert phosphorylation. |
2007-05-31 |
2023-08-12 |
rat |
| Sammanda Ramamoorthy, Devadoss J Samuvel, Eric R Buck, Gary Rudnick, Lankupalle D Jayanth. Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. The Journal of biological chemistry. vol 282. issue 16. 2007-05-31. PMID:17310063. |
although the t276a mutation had no significant effect on 5-ht transport or sert protein expression, mutation to aspartate (t276d) increased the level of 5-ht uptake to that of cgmp-stimulated 5-ht uptake in wild-type sert-expressing cells and was no longer sensitive to cgmp. |
2007-05-31 |
2023-08-12 |
rat |
| Markus Storvik, Jari Tiihonen, Tuija Haukijärvi, Erkki Tupal. Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography. Alcohol (Fayetteville, N.Y.). vol 40. issue 3. 2007-05-24. PMID:17418697. |
in this preliminary study, possible alterations of [3h]citalopram binding to serotonin transporter (sert) were evaluated in the nac of cloninger type 1 and 2 alcoholics (nine and seven subjects, respectively), and nonalcoholic controls (10 subjects) by human postmortem whole-hemisphere autoradiography. |
2007-05-24 |
2023-08-12 |
human |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| G Rudnic. Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722230. |
serotonin transporter (sert) serves the important function of taking up serotonin (5-ht) released during serotonergic neurotransmission. |
2007-05-23 |
2023-08-12 |
Not clear |
| G Rudnic. Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722230. |
sert catalyzes the influx of 5-ht together with na+ and cl- in a 1:1:1 stoichiometry. |
2007-05-23 |
2023-08-12 |
Not clear |
| M Guttman, I Boileau, J Warsh, J A Saint-Cyr, N Ginovart, T McCluskey, S Houle, A Wilson, E Mundo, P Rusjan, J Meyer, S J Kis. Brain serotonin transporter binding in non-depressed patients with Parkinson's disease. European journal of neurology. vol 14. issue 5. 2007-05-21. PMID:17437611. |
to address this question we measured, by positron emission tomography imaging, levels of the brain serotonin transporter (sert), a marker for serotonin neurones, as inferred from binding of [11c]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (dasb), a second generation sert radioligand, in subcortical and cerebral cortical brain areas of clinically advanced non-depressed (confirmed by structured psychiatric interview) patients with pd. |
2007-05-21 |
2023-08-12 |
Not clear |
| Karla Gravitt, Lesley Marso. Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. The journal of sexual medicine. vol 4. issue 2. 2007-05-18. PMID:17367427. |
aim; to examine the effect of lesions of brain neurons containing the serotonin reuptake transporter (sert) on ejaculatory-like reflexes. |
2007-05-18 |
2023-08-12 |
Not clear |
| Ian W Crai. The importance of stress and genetic variation in human aggression. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 29. issue 3. 2007-05-17. PMID:17295220. |
common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase a, maoa), or its re-uptake into pre-synaptic neurones (serotonin transporter, sert) have been shown to confer functional variation. |
2007-05-17 |
2023-08-12 |
human |
| Michael Stern, Sabine Knipp, Gerd Bicke. Embryonic differentiation of serotonin-containing neurons in the enteric nervous system of the locust (Locusta migratoria). The Journal of comparative neurology. vol 501. issue 1. 2007-05-08. PMID:17206618. |
cells developing to serotonergic phenotype express the serotonin uptake transporter (sert) significantly earlier, beginning at 40% of development. |
2007-05-08 |
2023-08-12 |
Not clear |
| Keith A Young, Leigh A Holcomb, Willy L Bonkale, Paul B Hicks, Umar Yazdani, Dwight C Germa. 5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Biological psychiatry. vol 61. issue 6. 2007-04-26. PMID:17083920. |
the 5httlpr genetic variant of the serotonin transporter (sert), which consists of a long (sert-l) and short (sert-s) allele, has emerged as a major factor influencing emotional behavior and brain anatomy. |
2007-04-26 |
2023-08-12 |
Not clear |
| Xiang Liu, Samuel D Banister, MacDonald J Christie, Richard Banati, Steve Meikle, Mark J Coster, Michael Kassio. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. European journal of pharmacology. vol 555. issue 1. 2007-04-26. PMID:17113074. |
both compounds have negligible affinity for the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters. |
2007-04-26 |
2023-08-12 |
Not clear |
| Piotr Popik, Martyna Krawczyk, Krystyna Golembiowska, Gabriel Nowak, Aaron Janowsky, Phil Skolnick, Arnold Lippa, Anthony S Basil. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16636898. |
radioligand binding to the dopamine (dat), norepinephrine (net), and serotonin (sert) transporters is inhibited with k (i) values of 222, 1030, and 740 nm, respectively. |
2007-04-24 |
2023-08-12 |
mouse |
| Nina Koldzic-Zivanovic, Patricia K Seitz, Kathryn A Cunningham, Mary L Thomas, Thomas K Hughe. Serotonin regulation of serotonin uptake in RN46A cells. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16858637. |
the role of the serotonin transporter (sert) is to remove serotonin (5-ht) from the synaptic space. |
2007-04-24 |
2023-08-12 |
Not clear |
| Nina Koldzic-Zivanovic, Patricia K Seitz, Kathryn A Cunningham, Mary L Thomas, Thomas K Hughe. Serotonin regulation of serotonin uptake in RN46A cells. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16858637. |
in vitro studies have shown that 5-ht uptake via sert is influenced by the availability of its substrate, 5-ht. |
2007-04-24 |
2023-08-12 |
Not clear |
| Nina Koldzic-Zivanovic, Patricia K Seitz, Kathryn A Cunningham, Mary L Thomas, Thomas K Hughe. Serotonin regulation of serotonin uptake in RN46A cells. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16858637. |
we used rn46a cells, a line that expresses sert, to investigate 5-ht regulation of 5-ht uptake and the intracellular signaling pathways involved. |
2007-04-24 |
2023-08-12 |
Not clear |