| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul D Callaghan, W Anthony Owens, Martin A Javors, Teresa A Sanchez, David J Jones, Rodney J Irvine, Lynette C Daw. In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17181558. |
the finding that 5-ht clearance in vivo was unaltered by mdma treatment suggests that in vitro measures of 5-ht axonal degeneration do not necessarily predict potential compensatory mechanisms that maintain sert function under basal conditions. |
2007-03-20 |
2023-08-12 |
rat |
| Yili Shang, Megan A Gibbs, Gerard J Marek, Thomas Stiger, Aaron H Burstein, Kenneth Marek, John P Seibyl, Janyce F Roger. Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. Journal of clinical psychopharmacology. vol 27. issue 1. 2007-03-20. PMID:17224717. |
both positron emission tomography and single photon emission computed tomography (spect) studies suggest that saturation of serotonin transporters (sert) is present during treatment with therapeutic doses of selective serotonin reuptake inhibitors (ssris). |
2007-03-20 |
2023-08-12 |
human |
| Yili Shang, Megan A Gibbs, Gerard J Marek, Thomas Stiger, Aaron H Burstein, Kenneth Marek, John P Seibyl, Janyce F Roger. Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. Journal of clinical psychopharmacology. vol 27. issue 1. 2007-03-20. PMID:17224717. |
a literature review of sert occupancy by marketed ssris and the snri venlafaxine using spect ([123i]beta-cit) or positron emission tomography ([11c](n, n-dimethyl-2-(2-amino-4-cyanophenylthio)-benzylamine) imaging suggests that therapeutic doses of snri are associated with virtual saturation of the serotonin transporter. |
2007-03-20 |
2023-08-12 |
human |
| Michael Camilleri, Christopher N Andrews, Adil E Bharucha, Paula J Carlson, Irene Ferber, Debra Stephens, Thomas C Smyrk, Raul Urrutia, Jeroen Aerssens, Leen Thielemans, Hinrich Göhlmann, Ilse van den Wyngaert, Bernard Couli. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241856. |
two proteins that influence the function of serotonin and serotonergic receptors are serotonin transporter protein (sert or soluble carrier protein, slc6a4) and p11 (s-100a10, or calpactin i light chain). |
2007-03-14 |
2023-08-12 |
Not clear |
| Michael D Gershon, Jan Tac. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241888. |
serotonin is inactivated by the serotonin reuptake transporter (sert)-mediated uptake into enterocytes or neurons. |
2007-03-14 |
2023-08-12 |
Not clear |
| N Klein, J Sacher, T Geiss-Granadia, T Attarbaschi, N Mossaheb, R Lanzenberger, C Pötzi, A Holik, C Spindelegger, S Asenbaum, R Dudczak, J Tauscher, S Kaspe. In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in healthy subjects administered different doses of escitalopram or citalopram. Psychopharmacology. vol 188. issue 3. 2007-03-13. PMID:16955282. |
previous studies pointed out that clinically efficacious doses of other ssris produce an occupancy of the serotonin reuptake transporter (sert) of about 80% or more. |
2007-03-13 |
2023-08-12 |
human |
| Leonard L Howell, F Ivy Carroll, John R Votaw, Mark M Goodman, Heather L Kimme. Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 320. issue 2. 2007-03-13. PMID:17105829. |
last, the dose of rti-336 that reduced cocaine-maintained behavior by 50% (ed(50)) was coadministered with the selective serotonin transporter (sert) inhibitors fluoxetine (3.0 mg/kg) and citalopram (3.0 mg/kg) to characterize their combined effects on cocaine self-administration. |
2007-03-13 |
2023-08-12 |
monkey |
| Yu-yuan Li, Yu-qiang Nie, Jun Xie, Hui-zhen Tan, Yong-jian Zhou, Hong Wan. [Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment]. Zhonghua nei ke za zhi. vol 45. issue 7. 2007-03-06. PMID:17074108. |
to investigate the serotonin reuptake transporter (sert) genetic polymorphisms in the 5-hydroxytryptamine (5-ht) transporter gene-linked polymorphic region (5-httlpr) and the variable number tandem repeats (vntrs) in intron 2 among chinese people, and their relationship to the pathogenesis of irritable bowel syndrome (ibs); and to investigate the impact of sert genotypes on the efficacy of 5-ht(4) receptor agonist tegaserod in constipation predominant type (c-ibs) patients. |
2007-03-06 |
2023-08-12 |
Not clear |
| Daniel Hoyer, Deepak R Thakker, François Natt, Rainer Maier, Dieter Huesken, Matthias Müller, Peter Flor, Herman VAN DER Putten, Markus Schmutz, Graeme Bilbe, John F Crya. Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118797. |
we then targeted endogenous genes, encoding the dopamine (dat) and serotonin transporters (sert). |
2007-03-06 |
2023-08-12 |
mouse |
| Amira K Brown, David T George, Masahiro Fujita, Jeih-San Liow, Masanori Ichise, Joseph Hibbeln, Subroto Ghose, Janet Sangare, Daniel Hommer, Robert B Inni. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism, clinical and experimental research. vol 31. issue 1. 2007-03-06. PMID:17207098. |
we measured densities of the serotonin transporter (sert) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. |
2007-03-06 |
2023-08-12 |
Not clear |
| Christopher D Verrico, Gregory M Miller, Bertha K Madra. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology. vol 189. issue 4. 2007-03-02. PMID:16220332. |
in rats, mdma-mediated effects are attributed, in part, to selective high-affinity transport of mdma into 5-ht neurons by the 5-ht transporter (sert), followed by extensive 5-ht release. |
2007-03-02 |
2023-08-12 |
human |
| John S Markowitz, C Lindsay DeVane, Linda K Pestreich, Kennerly S Patrick, Rafael Muni. A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. Journal of child and adolescent psychopharmacology. vol 16. issue 6. 2007-03-01. PMID:17201613. |
although binding affinity was not demonstrable at the serotonin (5-ht) transporter site (sert), novel findings of the study included affinity for the 5-ht1a and 5-ht2b receptor sites for both d- and l-mph, with d-mph exerting by far the most predominant effects at these sites. |
2007-03-01 |
2023-08-12 |
Not clear |
| Mingyan Zhou, Karen Engel, Joanne Wan. Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:17046718. |
the high affinity serotonin transporter (sert) constitutes the principal pathway for removal of serotonin (5-ht) from extracellular fluid of brain, but evidence indicates that other transporters may also be involved in this process. |
2007-02-22 |
2023-08-12 |
human |
| Mingyan Zhou, Karen Engel, Joanne Wan. Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:17046718. |
pre-hybridization of poly(a)(+) mrna with pmat or sert antisense oligonucleotides significantly reduced mrna-induced 5-ht uptake. |
2007-02-22 |
2023-08-12 |
human |
| Derick E Vergne, Charles B Nemerof. The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression. Current psychiatry reports. vol 8. issue 6. 2007-02-22. PMID:17094925. |
since the development of the selective serotonin (5-ht) reuptake inhibitors, a putative role for the 5-ht transporter (sert) in the etiology of depression has been explored. |
2007-02-22 |
2023-08-12 |
Not clear |
| Laura Bazzichi, Gino Giannaccini, Laura Betti, Giovanni Mascia, Laura Fabbrini, Paola Italiani, Francesca De Feo, Tiziana Giuliano, Camillo Giacomelli, Alessandra Rossi, Antonio Lucacchini, Stefano Bombardier. Alteration of serotonin transporter density and activity in fibromyalgia. Arthritis research & therapy. vol 8. issue 4. 2007-02-20. PMID:16790074. |
the aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter (sert) and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. |
2007-02-20 |
2023-08-12 |
human |
| Laura Bazzichi, Gino Giannaccini, Laura Betti, Giovanni Mascia, Laura Fabbrini, Paola Italiani, Francesca De Feo, Tiziana Giuliano, Camillo Giacomelli, Alessandra Rossi, Antonio Lucacchini, Stefano Bombardier. Alteration of serotonin transporter density and activity in fibromyalgia. Arthritis research & therapy. vol 8. issue 4. 2007-02-20. PMID:16790074. |
sert expression and functionality were evaluated through the measurement of [3h]paroxetine binding and the [3h]serotonin uptake itself. |
2007-02-20 |
2023-08-12 |
human |
| Ana M Catafau, Victor Perez, Pedro Plaza, Juan-Carlos Pascual, Santiago Bullich, Marina Suarez, Maria M Penengo, Iluminada Corripio, Dolors Puigdemont, Monica Danus, Javier Perich, Enric Alvare. Serotonin transporter occupancy induced by paroxetine in patients with major depression disorder: a 123I-ADAM SPECT study. Psychopharmacology. vol 189. issue 2. 2007-02-05. PMID:17033844. |
to assess the paroxetine-induced serotonin transporter (sert) occupancy (sertocc) using in vivo (123)i-adam spect. |
2007-02-05 |
2023-08-12 |
Not clear |
| Xue-Qin Li, Yang Hong, Yun Wang, Xin-Hua Zhang, Huai-Liang Wan. Sertraline protects against monocrotaline-induced pulmonary hypertension in rats. Clinical and experimental pharmacology & physiology. vol 33. issue 11. 2007-02-01. PMID:17042913. |
serotonin transporter (sert) mrna was assayed by reverse transcription-polymerase chain reaction (rt-pcr). |
2007-02-01 |
2023-08-12 |
rat |
| Cizhen Li, Hua Zhong, Yiyin Wang, Hongwei Wang, Zhifang Yang, Yanqian Zheng, Kai Liu, Yuanmou Li. Voltage and ionic regulation of human serotonin transporter in Xenopus oocytes. Clinical and experimental pharmacology & physiology. vol 33. issue 11. 2007-02-01. PMID:17042919. |
the serotonin (5-hydroxtryptamine; 5-ht) transporter (sert), which controls the synaptic 5-ht concentration through re-uptake of this neurotransmitter into presynaptic terminals, has been a primary therapeutic target for various psychiatric and peripheral disorders. |
2007-02-01 |
2023-08-12 |
human |