| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
the actions of 5ht are mediated by different types of receptors and terminated by a single 5ht transporter (sert). |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
therefore, sert is a major mechanism that regulates plasma 5ht levels to prevent vasoconstriction and thereby secure a stable blood flow. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
in this study, the response of platelet sert to the plasma 5ht levels was examined within two models: (i) in subjects with chronic hypertension or normotension; (ii) on platelets isolated from normotensive subjects and pretreated with 5ht at various concentrations. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
the platelet 5ht uptake rates were lower during hypertension due to a decrease in vmax with a similar km; also, the decrease in vmax was primarily due to a decrease in the density of sert on the platelet membrane, with no change in whole cell expression. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
furthermore, exogenous 5ht altered the 5ht uptake rates by changing the density of sert molecules on the plasma membrane in a biphasic manner. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
therefore, we hypothesize that in a hypertensive state, the elevated plasma 5ht levels induces a loss in 5ht uptake function in platelets via a decrease in the density of sert molecules on the plasma membrane. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
through the feedback effect of this proposed mechanism, plasma 5ht controls its own concentration levels by modulating the uptake properties of platelet sert. |
2007-07-30 |
2023-08-12 |
human |
| Shunichi Oya, Seok-Rye Choi, Mei-Ping Kung, Hank F Kun. 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand. Nuclear medicine and biology. vol 34. issue 2. 2007-07-20. PMID:17307121. |
two novel ligands with 4' substitution on the phenyl ring b of biphenylthiol, 5-chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine (7) and 2-(2'-((dimethylamino)methyl)-4'-methoxyphenylthio)-5-iodobenzenamine (8), were prepared and tested as potential serotonin transporter (sert) imaging agents. |
2007-07-20 |
2023-08-12 |
rat |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
the 5ht transporter (sert) on the membranes of the placental trophoblast cells controls 5ht levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5ht to the embryo. |
2007-07-12 |
2023-08-12 |
human |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
the 5ht uptake rate of placental sert is important for both the mother and the developing embryo. |
2007-07-12 |
2023-08-12 |
human |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
to understand better the role of glucose on the placental 5ht system, we first characterized sert in jar cells at different cell-cycle phases and then determined the expression levels of sert on the plasma membrane and in the intracellular pools of jar cells at the late-s and g2 phases, where the uptake rates were decreased 73% under diabetic-like glucose concentrations. |
2007-07-12 |
2023-08-12 |
human |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
therefore, we propose that under uncontrolled diabetic conditions, glucose down-regulates 5ht uptake rates of placental sert by interfering with its functional expression in a cell-cycle-dependent manner. |
2007-07-12 |
2023-08-12 |
human |
| M D Gersho. 5-HT (serotonin) physiology and related drugs. Current opinion in gastroenterology. vol 16. issue 2. 2007-07-03. PMID:17024028. |
the 5-ht that is involved in mucosal signaling is inactivated by uptake into mucosal epithelial cells, which are mediated by an integral membrane protein called the serotonin reuptake transporter (sert). |
2007-07-03 |
2023-08-12 |
Not clear |
| M D Gersho. 5-HT (serotonin) physiology and related drugs. Current opinion in gastroenterology. vol 16. issue 2. 2007-07-03. PMID:17024028. |
the epithelial sert is the same molecule as that which transports 5-ht in the central and enteric nervous systems. |
2007-07-03 |
2023-08-12 |
Not clear |
| Mikko Joensuu, Tommi Tolmunen, Pirjo I Saarinen, Jari Tiihonen, Jyrki Kuikka, Pasi Ahola, Ritva Vanninen, Johannes Lehtone. Reduced midbrain serotonin transporter availability in drug-naïve patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging. Psychiatry research. vol 154. issue 2. 2007-07-03. PMID:17289353. |
earlier results have indicated that serotonin transporter (sert) availability is altered in major depression. |
2007-07-03 |
2023-08-12 |
Not clear |
| Yen Kuang Yang, Wei Jen Yao, Tzung Lieh Yeh, I Hui Lee, Kao Ching Chen, Ru Band L. Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM. Psychiatry research. vol 154. issue 3. 2007-07-03. PMID:17349781. |
the present study examined the relationship between serotonin transporter (sert) availability and hostility scores in healthy volunteers. |
2007-07-03 |
2023-08-12 |
human |
| A Dahlin, L Xia, W Kong, R Hevner, J Wan. Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience. vol 146. issue 3. 2007-07-03. PMID:17408864. |
mpmat is co-expressed in many brain regions with the high affinity 5-ht transporter (sert) and the dopamine transporter (dat), but is also found in certain sites that receive monoamine innervation but lack significant expression of sert or dat. |
2007-07-03 |
2023-08-12 |
mouse |
| Bhavik Anil Patel, Xiaochun Bian, Veronika Quaiserová-Mocko, James J Galligan, Greg M Swai. In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum. The Analyst. vol 132. issue 1. 2007-07-02. PMID:17180178. |
the 5-ht oxidation current increased in the presence of the serotonin transporter (sert) inhibitor, fluoxetine (1 microm), providing evidence that the oxidation current was associated with 5-ht. |
2007-07-02 |
2023-08-12 |
Not clear |
| Ruth Iceta, José E Mesonero, Ana I Alcald. Effect of long-term fluoxetine treatment on the human serotonin transporter in Caco-2 cells. Life sciences. vol 80. issue 16. 2007-06-28. PMID:17289086. |
the chronic effect of ssris on the activity of the serotonin transporter (sert) has been less studied and the results have been contradictory. |
2007-06-28 |
2023-08-12 |
human |
| Nikolas Klein, Julia Sacher, Thomas Geiss-Granadia, Nilufar Mossaheb, Trawat Attarbaschi, Rupert Lanzenberger, Christoph Spindelegger, Alexander Holik, Susanne Asenbaum, Robert Dudczak, Johannes Tauscher, Siegfried Kaspe. Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study. Psychopharmacology. vol 191. issue 2. 2007-06-25. PMID:17235610. |
previous studies have investigated the occupancy of the serotonin reuptake transporter (sert) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. |
2007-06-25 |
2023-08-12 |
Not clear |