| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonia L Pritchard, Colin W Pritchard, Peter Bentham, Corinne L Lendo. Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer disease patients. Dementia and geriatric cognitive disorders. vol 24. issue 3. 2007-10-29. PMID:17690552. |
this is an investigation of whether the linked polymorphic region and variable number tandem repeat variants of the serotonin transporter (sert) are associated with bpsd. |
2007-10-29 |
2023-08-12 |
Not clear |
| Ana Paula de Magalhães-Nunes, Daniel Badauê-Passos, Renato Rizo Ventura, Daniel da Silva Guedes, Jacqueline Pereira Araújo, Priscila Camargo Granadeiro, Hevellyn Katarine Milanez-Barbosa, Ricardo Henrique da Costa-e-Sousa, Magda Alves de Medeiros, José Antunes-Rodrigues, Luís Carlos Rei. Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats. Experimental physiology. vol 92. issue 5. 2007-10-26. PMID:17573416. |
we investigated the effects of chronic administration of sertraline (sert; approximately 20 mg kg(-1) day(-1) in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake and on plasma levels of oxytocin (ot) and vasopressin (avp) in basal and stimulated conditions. |
2007-10-26 |
2023-08-12 |
rat |
| M S Clark, R A McDevitt, B J Hoplight, J F Neumaie. Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467184. |
following behavioral testing, 5-ht1a, 5-ht1b, 5-ht transporter (sert), and tryptophan hydroxylase-2 (tph2) expression was examined through the drn by in situ hybridization. |
2007-10-25 |
2023-08-12 |
human |
| J R Homberg, J D A Olivier, B M G Smits, J D Mul, J Mudde, M Verheul, O F M Nieuwenhuizen, A R Cools, E Ronken, T Cremers, A N M Schoffelmeer, B A Ellenbroek, E Cuppe. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467186. |
here, we describe the functional characterization of the serotonin transporter (sert) knockout rat model, that is generated by n-ethyl-n-nitrosurea (enu)-driven target-selected mutagenesis. |
2007-10-25 |
2023-08-12 |
rat |
| J R Homberg, J D A Olivier, B M G Smits, J D Mul, J Mudde, M Verheul, O F M Nieuwenhuizen, A R Cools, E Ronken, T Cremers, A N M Schoffelmeer, B A Ellenbroek, E Cuppe. Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467186. |
in conclusion, neurochemical changes in the sert knockout rat are primarily limited to the serotonergic system, making this novel rat model potentially very useful for studying the behavioral and neurobiological consequences of disturbed 5-ht homeostasis. |
2007-10-25 |
2023-08-12 |
rat |
| R Spille. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19 Suppl 2. 2007-10-23. PMID:17620085. |
rapid reuptake by a specific transporter (serotonin transporter, sert) limits its diffusion and actions. |
2007-10-23 |
2023-08-12 |
human |
| R Spille. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 19 Suppl 2. 2007-10-23. PMID:17620085. |
impaired sert has been described in ibs-d and might account for some of the increase in mucosal 5-ht availability. |
2007-10-23 |
2023-08-12 |
human |
| Christophe Plisson, Jeffrey S Stehouwer, Ronald J Voll, Leonard Howell, John R Votaw, Michael J Owens, Mark M Goodma. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. Journal of medicinal chemistry. vol 50. issue 19. 2007-10-23. PMID:17705359. |
2beta-carbo(2-fluoroethoxy)-3beta-(4'-((z)-2-iodoethenyl)phenyl)nortropane (betafepzient, 1) was synthesized as a serotonin transporter (sert) imaging agent for both positron emission tomography (pet) and single photon emission computerized tomography (spect). |
2007-10-23 |
2023-08-12 |
human |
| Ralph Buchert, Frank Thiele, Rainer Thomasius, Florian Wilke, Kay Petersen, Winfried Brenner, Janos Mester, Lothar Spies, Malte Clause. Ecstasy-induced reduction of the availability of the brain serotonin transporter as revealed by [11C](+)McN5652-PET and the multi-linear reference tissue model: loss of transporters or artifact of tracer kinetic modelling? Journal of psychopharmacology (Oxford, England). vol 21. issue 6. 2007-10-18. PMID:17092972. |
in a previous positron emission tomography (pet) study with the serotonin transporter (sert) ligand [(11)c](+)mcn5652, we found protracted reduction of the availability of the brain sert in users of the drug ecstasy. |
2007-10-18 |
2023-08-12 |
human |
| P Dorado, E M Peñas-Lledó, A P González, M C Cáceres, J Cobaleda, A Lleren. Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele. Fundamental & clinical pharmacology. vol 21. issue 4. 2007-10-18. PMID:17635185. |
in the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter (sert or 5-htt) gene (5-httlpr) and the risk of suffering major depression (mdd) in a population of patients previously genotyped for cyp2c9. |
2007-10-18 |
2023-08-12 |
human |
| J B Hoffman, J R Kaplan, B Kinkead, S L Berga, M E Wilso. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta). Endocrine. vol 31. issue 2. 2007-10-18. PMID:17873333. |
the serotonin (5ht) reuptake transporter (sert) plays a key role in 5ht homeostasis by recycling 5ht into the presynaptic neurons. |
2007-10-18 |
2023-08-12 |
monkey |
| J B Hoffman, J R Kaplan, B Kinkead, S L Berga, M E Wilso. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta). Endocrine. vol 31. issue 2. 2007-10-18. PMID:17873333. |
recently, polymorphisms in the length of the promoter region of the gene that encodes sert have been linked to functional differences in reactivity to psychosocial stress, as the short (s) promoter length allele shows reduced transcriptionally activity in vitro and is associated with reduced 5ht activity and increased vulnerability to affective disorders. |
2007-10-18 |
2023-08-12 |
monkey |
| J B Hoffman, J R Kaplan, B Kinkead, S L Berga, M E Wilso. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta). Endocrine. vol 31. issue 2. 2007-10-18. PMID:17873333. |
given 5ht's important role in appetite regulation, polymorphisms in the sert gene could also affect metabolic parameters. |
2007-10-18 |
2023-08-12 |
monkey |
| J B Hoffman, J R Kaplan, B Kinkead, S L Berga, M E Wilso. Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta). Endocrine. vol 31. issue 2. 2007-10-18. PMID:17873333. |
in addition, since reduced 5ht activity may also predispose females to reproductive deficits, polymorphisms in the sert gene may help explain individual differences in ovulatory function. |
2007-10-18 |
2023-08-12 |
monkey |
| Paul K Gong, Bruce E Blough, Lawrence E Brieaddy, Xiaodong Huang, Michael J Kuhar, Hernán A Navarro, F Ivy Carrol. Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. Journal of medicinal chemistry. vol 50. issue 15. 2007-10-15. PMID:17602602. |
in general, the compounds showed higher dopamine transporter (dat) affinity relative to the serotonin and norepinephrine transporters (sert and net, respectively) and greater [3h]dopamine uptake inhibition potency relative to [3h]serotonin and [3h]norepinephrine uptake inhibition. |
2007-10-15 |
2023-08-12 |
rat |
| Manfred G Ismair, Gerd A Kullak-Ublick, Randy D Blakely, Michael Fried, Stephan R Vavrick. Tegaserod inhibits the serotonin transporter SERT. Digestion. vol 75. issue 2-3. 2007-10-12. PMID:17510552. |
tegaserod inhibits the serotonin transporter sert. |
2007-10-12 |
2023-08-12 |
human |
| Werner Zitterl, Martin Aigner, Thomas Stompe, Karin Zitterl-Eglseer, Karin Gutierrez-Lobos, Brigitte Schmidl-Mohl, Thomas Wenzel, Ulrike Demal, Georg Zettinig, Kurt Hornik, Kenneth Tha. [123I]-beta-CIT SPECT imaging shows reduced thalamus-hypothalamus serotonin transporter availability in 24 drug-free obsessive-compulsive checkers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17192774. |
we investigated the in vivo availability of thalamus-hypothalamus serotonin transporters (sert) in patients with dsm-iv ocd who displayed prominent behavioral checking compulsions (oc-checkers). |
2007-09-26 |
2023-08-12 |
human |
| Satinder K Singh, Atsuko Yamashita, Eric Gouau. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. vol 448. issue 7156. 2007-09-26. PMID:17687333. |
antagonist dissociation experiments on the serotonin transporter (sert) have also unveiled the existence of a low-affinity allosteric site that slows the dissociation of inhibitors from a separate high-affinity site. |
2007-09-26 |
2023-08-12 |
Not clear |
| Jeannette M Watson, Lee A Dawso. Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy. CNS drug reviews. vol 13. issue 2. 2007-09-21. PMID:17627673. |
the current studies review the profile of sb-649915 (6-[(1-{2-[(2-methylquinolin-5-yl)oxy]ethyl}piperidin-4-yl)methyl]-2h-1,4-benzoxazin-3(4h)-one), a novel compound with high affinity for human (h) 5-ht1a and 5-ht1b receptors (pki values of 8.6 and 8.0, respectively) as well as the (h) 5-ht transporter (sert) (pki value of 9.3). |
2007-09-21 |
2023-08-12 |
human |
| Zheng Zhou, Juan Zhen, Nathan K Karpowich, Regina M Goetz, Christopher J Law, Maarten E A Reith, Da-Neng Wan. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.). vol 317. issue 5843. 2007-09-21. PMID:17690258. |
tricyclic antidepressants exert their pharmacological effect-inhibiting the reuptake of serotonin, norepinephrine, and dopamine-by directly blocking neurotransmitter transporters (sert, net, and dat, respectively) in the presynaptic membrane. |
2007-09-21 |
2023-08-12 |
human |