| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
thus, when dat is inhibited by gbr 12909, kinetic parameters for serotonin uptake via sert in striatum are not different from those obtained in hippocampus. |
2008-03-21 |
2023-08-12 |
rat |
| Ann J Barbier, Leah Aluisio, Brian Lord, Ying Qu, Sandy J Wilson, Jamin D Boggs, Pascal Bonaventure, Kirsten Miller, Ian Fraser, Lisa Dvorak, Cindy Pudiak, Christine Dugovic, Jonathan Shelton, Curt Mazur, Michael A Letavic, Nicholas I Carruthers, Timothy W Lovenber. Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor. European journal of pharmacology. vol 576. issue 1-3. 2008-03-06. PMID:17765221. |
jnj-28583867 (2-methyl-4-(4-methylsulfanyl-phenyl)-7-(3-morpholin-4-yl-propoxy)-1,2,3,4-tetrahydro-isoquinoline) is a selective and potent histamine h(3) receptor antagonist (k(i)=10.6 nm) and inhibitor of the serotonin transporter (sert) (k(i)=3.7 nm), with 30-fold selectivity for sert over the dopamine and norepinephrine transporters. |
2008-03-06 |
2023-08-12 |
mouse |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
evidence for a brain serotonergic disturbance in pd is derived in large part from findings of decreased binding of different radioligands to the serotonin transporter (sert), one 'marker' of serotonin neurons. |
2008-03-06 |
2023-08-12 |
Not clear |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
however, it is not known whether the reported changes in sert binding reflect actual changes in levels of sert protein or whether concentrations of all serotonin markers are similarly and markedly decreased in the two striatal subdivisions. |
2008-03-06 |
2023-08-12 |
Not clear |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
we measured levels of sert immunoreactivity, and for comparison, protein levels of tryptophan hydroxylase (tph; the marker synthetic enzyme) using a western blot procedure, as well as concentrations of serotonin, its metabolite 5-hydroxyindoleacetic acid (5-hiaa), and dopamine by hplc in post-mortem striatum of patients with pd and normal controls. |
2008-03-06 |
2023-08-12 |
Not clear |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
unlike the preferential loss of dopamine in putamen, the caudate was affected more than putamen by loss of all serotonin markers: serotonin (-66% versus -51%), 5-hiaa (-42% versus -31%), sert (-56% versus -30%) and tph (-59% versus -32%). |
2008-03-06 |
2023-08-12 |
Not clear |
| Meredith A Fox, Anne M Andrews, Jens R Wendland, Klaus-Peter Lesch, Andrew Holmes, Dennis L Murph. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter. Psychopharmacology. vol 195. issue 2. 2008-02-25. PMID:17712549. |
partial or complete ablation of serotonin transporter (sert) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs. |
2008-02-25 |
2023-08-12 |
mouse |
| Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalk. Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Neurotoxicology and teratology. vol 29. issue 6. 2008-02-25. PMID:17761399. |
reverse transcriptase polymerase chain reaction (rt-pcr) was performed to determine the relative levels of a serotonin transporter protein (sert) transcript and the serotonin 1a (5-ht(1a)) receptor transcript in developing embryos/larvae over 1-6 dpf. |
2008-02-25 |
2023-08-12 |
zebrafish |
| Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalk. Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Neurotoxicology and teratology. vol 29. issue 6. 2008-02-25. PMID:17761399. |
rt-pcr was also used to detect potential changes in the sert and 5-ht(1a) receptor transcripts in 6 dpf larvae after a 24 h exposure to 4.6 microm fluoxetine on 5 dpf. |
2008-02-25 |
2023-08-12 |
zebrafish |
| Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalk. Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Neurotoxicology and teratology. vol 29. issue 6. 2008-02-25. PMID:17761399. |
these results suggest a correlation between decreased concentration of sert and 5-ht(1a) receptor transcripts in spinal cord and decreased ssa subsequent to fluoxetine exposure. |
2008-02-25 |
2023-08-12 |
zebrafish |
| Susan Schenk, Lincoln Hely, Barbara Lake, Evangelene Daniela, David Gittings, Deborah C Mas. MDMA self-administration in rats: acquisition, progressive ratio responding and serotonin transporter binding. The European journal of neuroscience. vol 26. issue 11. 2008-02-25. PMID:18005064. |
radioligand binding and autoradiography demonstrated lower densities of serotonin transporter sites (sert) in mdma self-administering rats as compared with controls across brain regions. |
2008-02-25 |
2023-08-12 |
rat |
| Ravinder K Gill, Nitika Pant, Seema Saksena, Amika Singla, Talat M Nazir, Lisa Vohwinkel, Jerrold R Turner, Jay Goldstein, Waddah A Alrefai, Pradeep K Dudej. Function, expression, and characterization of the serotonin transporter in the native human intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 1. 2008-02-21. PMID:17991706. |
the enteric serotonin transporter (sert) plays a critical role in modulating serotonin availability and thus has been implicated in the pathogenesis of various intestinal disorders. |
2008-02-21 |
2023-08-12 |
human |
| Ravinder K Gill, Nitika Pant, Seema Saksena, Amika Singla, Talat M Nazir, Lisa Vohwinkel, Jerrold R Turner, Jay Goldstein, Waddah A Alrefai, Pradeep K Dudej. Function, expression, and characterization of the serotonin transporter in the native human intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 1. 2008-02-21. PMID:17991706. |
functional studies showed that uptake of [(3)h]serotonin (150 nm) in human ileal amvs was 1) significantly increased in the presence of both na(+) and cl(-); 2) inhibited ( approximately 50%) by the neuronal sert inhibitor, fluoxetine (10 microm) and by unlabeled 5-ht; and 3) exhibited saturation kinetics indicating the presence of a carrier-mediated process. |
2008-02-21 |
2023-08-12 |
human |
| Ravinder K Gill, Nitika Pant, Seema Saksena, Amika Singla, Talat M Nazir, Lisa Vohwinkel, Jerrold R Turner, Jay Goldstein, Waddah A Alrefai, Pradeep K Dudej. Function, expression, and characterization of the serotonin transporter in the native human intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 1. 2008-02-21. PMID:17991706. |
our studies demonstrated differential expression of sert across various regions of the human intestine and provide evidence for the existence of a functional sert capable of removing intraluminal serotonin in human ileal epithelial cells. |
2008-02-21 |
2023-08-12 |
human |
| Fanxing Zeng, Nachwa Jarkas, Jeffrey S Stehouwer, Ronald J Voll, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorganic & medicinal chemistry. vol 16. issue 2. 2008-02-20. PMID:17983754. |
six new (s,s)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (net), serotonin transporter (sert) or dopamine transporter (dat). |
2008-02-20 |
2023-08-12 |
human |
| Mona M Hanna, Nahed M Eid, Riham F George, Hani M Safwa. Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin. Bioorganic & medicinal chemistry. vol 15. issue 24. 2008-02-19. PMID:17870537. |
the prepared compounds were tested for their activity and selectivity toward the norepinephrine transporter (net) and serotonin transporter (sert) using yohimbine-induced mortality and 5-hydroxytryptophan-induced neurotoxicity in mice, respectively. |
2008-02-19 |
2023-08-12 |
mouse |
| Nada Bozina, Vesna Medved, Martina Rojnic Kuzman, Ivica Sain, Jadranka Serti. Association study of olanzapine-induced weight gain and therapeutic response with SERT gene polymorphisms in female schizophrenic patients. Journal of psychopharmacology (Oxford, England). vol 21. issue 7. 2008-02-15. PMID:17092963. |
we investigated the relationships between l/s promoter (sertpr) and l/s intron2 (sertin2) genetic variants of serotonin transporter (sert) polymorphisms with olanzapine-induced weight gain and treatment response in 94 female schizophrenic patients treated with olanzapine for up to 3 months. |
2008-02-15 |
2023-08-12 |
human |
| François Dubé, Pascal Amireaul. Local serotonergic signaling in mammalian follicles, oocytes and early embryos. Life sciences. vol 81. issue 25-26. 2008-02-15. PMID:18023821. |
additional serotonergic players, including the 5-ht transporter (sert or slc6a4) expressed in oocytes and embryos, and the 5-ht-producing enzyme tryptophan hydroxylase-1 (tph1) expressed in cumulus cells, now make up a complete and autonomous local serotonergic network. |
2008-02-15 |
2023-08-12 |
mouse |
| B M Way, G Laćan, L A Fairbanks, W P Meleg. Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey. Neuroscience. vol 148. issue 4. 2008-02-14. PMID:17766046. |
to elucidate the organization of the serotoninergic innervation within the orbitofrontal cortex (ofc), serotonin transporter (sert) density was quantified by autoradiography using [(3)h]cyanoimipramine binding. |
2008-02-14 |
2023-08-12 |
monkey |
| Anna Moskwa, Patrycja Boznańsk. [Role of serotonin in the pathophysiology of the irritable bowel syndrome]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 7-8. 2008-02-08. PMID:18175558. |
enterocytes express the serotonin reuptake transporter (sert), which terminate the action of 5-ht. |
2008-02-08 |
2023-08-12 |
Not clear |