| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nachwa Jarkas, Ronald J Voll, Larry Williams, John R Votaw, Mike Owens, Mark M Goodma. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. Journal of medicinal chemistry. vol 51. issue 2. 2008-04-17. PMID:18085744. |
n, n-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (38), substituted on ring a, was reported to display high binding affinity and selectivity to the human brain serotonin transporter (sert). |
2008-04-17 |
2023-08-12 |
human |
| L Keith Henry, Jens Meiler, Randy D Blakel. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular interventions. vol 7. issue 6. 2008-04-17. PMID:18199851. |
the neurotransmitter transporters belonging to the solute carrier 6 (slc6) family, including the gamma-aminobutyric acid (gat), norepinephrine (net), serotonin (sert) and dopamine (dat) transporters are extremely important drug targets of great clinical relevance. |
2008-04-17 |
2023-08-12 |
human |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
heterozygous mutants bdnf +/- mice were utilized to investigate the influence of bdnf on the serotonin (5-ht) system and the activity of the serotonin transporter (sert) in the hippocampus. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
a significant decrease in [3h]citalopram-binding-site density in the ca3 subregion of the ventral hippocampus and a significant reduction in [3h]5-ht uptake in hippocampal synaptosomes, revealed mainly a decrease in sert function. |
2008-04-15 |
2023-08-12 |
mouse |
| M R MacLea. Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement. issue 156. 2008-04-14. PMID:17663674. |
the serotonin is released and can then: (i) pass into the underlying pulmonary smooth muscle cells through the serotonin transporter (sert) to initiate proliferation and/or (ii) activate serotonin receptors on pulmonary smooth muscle cells to evoke proliferation and/or contraction. |
2008-04-14 |
2023-08-12 |
human |
| M R MacLea. Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement. issue 156. 2008-04-14. PMID:17663674. |
serotonin may also mediate pulmonary fibroblast proliferation via the sert and/or serotonin receptors. |
2008-04-14 |
2023-08-12 |
human |
| M R MacLea. Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement. issue 156. 2008-04-14. PMID:17663674. |
in conclusion, the activity of serotonin receptors, the sert and tph1 can all be elevated in clinical and experimental pah and each offers a potentially unique therapeutic target. |
2008-04-14 |
2023-08-12 |
human |
| C M Krall, J B Richards, R A Rabin, J C Winte. Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17935763. |
in genetically modified mice lacking the serotonin transporter (sert), 5-ht2a receptor density is decreased and, at a functional level, the head-twitch response following the administration of doi, an index of activation of 5-ht2a receptors, is reduced. |
2008-04-09 |
2023-08-12 |
mouse |
| Ajit K Parhi, Julie L Wang, Shunichi Oya, Seok-Rye Choi, Mei-Ping Kung, Hank F Kun. 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)-phenylthio)benzenamine derivatives as serotonin transporter imaging agents. Journal of medicinal chemistry. vol 50. issue 26. 2008-04-03. PMID:18052090. |
a novel series of ligands with substitutions at the 5-position on phenyl ring a and at the 4'-position on phenyl ring b of 2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine (4'-2-fluoroethoxy derivatives 28-31 and 4'-3-fluoropropoxy derivatives 40-42) were prepared and tested as serotonin transporter (sert) imaging agents. |
2008-04-03 |
2023-08-12 |
rat |
| Oliver Pogarell, Walter Koch, Nadine Schaaff, Gabriele Pöpperl, Christoph Mulert, Georg Juckel, Hans-Jürgen Möller, Ulrich Hegerl, Klaus Tatsc. [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials. European archives of psychiatry and clinical neuroscience. vol 258. issue 1. 2008-03-31. PMID:17990053. |
the loudness dependence of auditory evoked potentials (ld) has been proposed as an indirect indicator of cortical serotonergic activity, whereas single photon emission computed tomography (spect) and [123i]adam allow the selective assessment of brain serotonin transporters (sert). |
2008-03-31 |
2023-08-12 |
human |
| Kristofer Thorslund, Klas Nordlin. Serotonergic drugs--a possible role in the treatment of psoriasis? Drug news & perspectives. vol 20. issue 8. 2008-03-27. PMID:18080039. |
5-ht 1a receptor-positive mast cells, and 5-ht 2a receptor and serotonin reuptake transporter (sert)-positive t lymphocytes may be targets for therapy with serotonergic drugs in psoriasis. |
2008-03-27 |
2023-08-12 |
Not clear |
| Yosuke Yamauchi, Takaya Izumi, Kazuhiro Unemura, Yoshie Uenishi, Takayuki Nakagawa, Shuji Kanek. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions. Neuroscience letters. vol 428. issue 2-3. 2008-03-26. PMID:17949903. |
3,4-methylenedioxymethamphetamine (mdma) selectively releases serotonin (5-ht) from neurons after uptake by the serotonin transporter (sert) and causes psychostimulant effects accompanied by hyperthermia. |
2008-03-26 |
2023-08-12 |
xenopus_laevis |
| Yosuke Yamauchi, Takaya Izumi, Kazuhiro Unemura, Yoshie Uenishi, Takayuki Nakagawa, Shuji Kanek. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions. Neuroscience letters. vol 428. issue 2-3. 2008-03-26. PMID:17949903. |
perfusion with sert substrates at ph 7.4 dose-dependently evoked a transport-associated inward current response with the following rank order of potency: 5-ht>mdma>dopamine>>norepinephrine. |
2008-03-26 |
2023-08-12 |
xenopus_laevis |
| Alessandro Zarpellon, Arianna Donella-Deana, Alessandra Folda, Loris Turetta, Martina Pavanetto, Renzo Dean. Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 1-3. 2008-03-26. PMID:18209475. |
serotonin (5-ht) transport in human platelets is modulated by src-catalysed tyr-phosphorylation of the plasma membrane transporter sert. |
2008-03-26 |
2023-08-12 |
human |
| Alessandro Zarpellon, Arianna Donella-Deana, Alessandra Folda, Loris Turetta, Martina Pavanetto, Renzo Dean. Serotonin (5-HT) transport in human platelets is modulated by Src-catalysed Tyr-phosphorylation of the plasma membrane transporter SERT. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 1-3. 2008-03-26. PMID:18209475. |
this study analysed whether the 5-ht transport mediated by the plasma-membrane transporter sert is regulated by its tyr-phosphorylation. |
2008-03-26 |
2023-08-12 |
human |
| Dennis L Murphy, Alicja Lerner, Gary Rudnick, Klaus-Peter Lesc. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Molecular interventions. vol 4. issue 2. 2008-03-24. PMID:15087484. |
the highly evolutionarily conserved serotonin transporter (sert) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. |
2008-03-24 |
2023-08-12 |
mouse |
| Dennis L Murphy, Alicja Lerner, Gary Rudnick, Klaus-Peter Lesc. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Molecular interventions. vol 4. issue 2. 2008-03-24. PMID:15087484. |
replicated studies have demonstrated that the sert 5'-flanking region polymorphism ss genotype is associated with poorer therapeutic responses and more frequent serious side effects during treatment with antidepressant sert antagonists, namely, the serotonin reuptake inhibitors (sris). |
2008-03-24 |
2023-08-12 |
mouse |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
for example, serotonin is transported by the dopamine transporter (dat) under conditions in which serotonin transporter (sert) activity is eliminated (e.g., pharmacological inhibition). |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
we performed a kinetic analysis of [(3)h]serotonin uptake in rat striatal synaptosomes (expressing dat and sert) and hippocampal synaptosomes (expressing sert, but not dat). |
2008-03-21 |
2023-08-12 |
rat |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
these data suggest that, at the concentrations employed, fluoxetine inhibits serotonin uptake at both dat and sert, whereas paroxetine only inhibits serotonin uptake at sert. |
2008-03-21 |
2023-08-12 |
rat |