| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
a sert knockout (ko) rat is a useful model to test the hypothesis that sert is the primary mechanism for arterial 5-ht uptake and to investigate the impact of sert removal on blood pressure. |
2008-05-29 |
2023-08-12 |
rat |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
these data suggest that there are other mechanisms of 5-ht uptake in the arteries of the rat and that although the absence of circulating 5-ht and/or sert function sensitizes arteries to 5-ht, sert dysfunction does not impair normal blood pressure. |
2008-05-29 |
2023-08-12 |
rat |
| Gang Zhao, Shao-Yun Zang, Xiang-Wei Zheng, Xiao-Hua Zhang, Li-He Gu. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18329002. |
monoamine transporter inhibition by delta3,2-hydroxybakuchiol was more selective for the dopamine transporter (dat) (ic50=0.58+/-0.1 microm) and norepinephrine transporter (net) (ic50=0.69+/-0.12 microm) than for the serotonin transporter (sert) (ic50=312.02+/-56.69 microm). |
2008-05-27 |
2023-08-12 |
mouse |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
the serotonin transporter (sert) on the plasma membrane is the major mechanism for the clearance of plasma serotonin (5-hydroxytryptamine (5ht)). |
2008-05-22 |
2023-08-12 |
Not clear |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
interestingly, the number of sert molecules on the platelet surface is down-regulated when plasma 5ht ([5ht](ex)) is elevated. |
2008-05-22 |
2023-08-12 |
Not clear |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
although investigating the mechanism by which elevated plasma 5ht level down-regulates the density of sert molecules on the plasma membrane, we studied rab4 and sert in heterologous and platelet expression systems. |
2008-05-22 |
2023-08-12 |
Not clear |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
our data demonstrate that, in response to elevated [5ht](ex), rab4-gtp co-localizes with and binds to sert. |
2008-05-22 |
2023-08-12 |
Not clear |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
the association of sert with rab4-gtp depends on: (i) 5ht modification and (ii) the gtp-binding ability of rab4. |
2008-05-22 |
2023-08-12 |
Not clear |
| Billow A Ahmed, Brandon C Jeffus, Syed I A Bukhari, Justin T Harney, Resat Unal, Vladimir V Lupashin, Peter van der Sluijs, Fusun Kili. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. The Journal of biological chemistry. vol 283. issue 14. 2008-05-22. PMID:18227069. |
therefore, we propose that elevated [5ht](ex)"paralyzes" the translocation of sert from intracellular locations to the plasma membrane by controlling transamidation and rab4-gtp formation. |
2008-05-22 |
2023-08-12 |
Not clear |
| Jens R Wendland, Theresa B DeGuzman, Francis McMahon, Gary Rudnick, Sevilla D Detera-Wadleigh, Dennis L Murph. SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatric genetics. vol 18. issue 1. 2008-05-16. PMID:18197083. |
sert i425v, an uncommon missense single nucleotide polymorphism producing a gain-of-function of the serotonin transporter (sert), was originally found to segregate with a primarily obsessive-compulsive disorder (ocd) but complexly comorbid phenotype in two unrelated families. |
2008-05-16 |
2023-08-12 |
Not clear |
| Ana Marin D Carneiro, Edwin H Cook, Dennis L Murphy, Randy D Blakel. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. The Journal of clinical investigation. vol 118. issue 4. 2008-05-16. PMID:18317590. |
the essential contribution of the antidepressant-sensitive serotonin (5-ht) transporter sert (which is encoded by the slc6a4 gene) to platelet 5-ht stores suggests an important role of this transporter in platelet function. |
2008-05-16 |
2023-08-12 |
mouse |
| Ana Marin D Carneiro, Edwin H Cook, Dennis L Murphy, Randy D Blakel. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. The Journal of clinical investigation. vol 118. issue 4. 2008-05-16. PMID:18317590. |
additionally, using pharmacological blockers of sert and the vesicular monoamine transporter (vmat), we have identified a role for ongoing 5-ht release and sert activity in efficient human platelet aggregation. |
2008-05-16 |
2023-08-12 |
mouse |
| Iain J A Macdougall, Renate Griffit. Pharmacophore design and database searching for selective monoamine neurotransmitter transporter ligands. Journal of molecular graphics & modelling. vol 26. issue 7. 2008-05-15. PMID:18023378. |
various structural classes of compounds have been synthesized and tested in vitro for activity against transporters of three monoamine signaling molecules: noradrenaline (net); serotonin (sert) and dopamine (dat). |
2008-05-15 |
2023-08-12 |
Not clear |
| Ivett Medina-Aguirre, Gabriel Gutiérrez-Ospina, Jorge Hernández-Rodríguez, Alfonso Boyzo, Gabriel Manjarrez-Gutiérre. Development of 5-HT(1B), SERT and thalamo-cortical afferents in early nutrionally restricted rats: an emerging explanation for delayed barrel formation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 2. 2008-05-13. PMID:18207350. |
development of 5-ht(1b), sert and thalamo-cortical afferents in early nutrionally restricted rats: an emerging explanation for delayed barrel formation. |
2008-05-13 |
2023-08-12 |
rat |
| Ivett Medina-Aguirre, Gabriel Gutiérrez-Ospina, Jorge Hernández-Rodríguez, Alfonso Boyzo, Gabriel Manjarrez-Gutiérre. Development of 5-HT(1B), SERT and thalamo-cortical afferents in early nutrionally restricted rats: an emerging explanation for delayed barrel formation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 2. 2008-05-13. PMID:18207350. |
we then evaluated the pattern of immunostaining of the serotonin transporter (sert) and of the serotonin receptor 1b (5-ht(1b)), as well as the growth and arrival time of somatosensory thalamo-cortical afferents, to infer the contribution of these elements in the delayed formation of barrels observed in nutritionally restricted rats. |
2008-05-13 |
2023-08-12 |
rat |
| Ivett Medina-Aguirre, Gabriel Gutiérrez-Ospina, Jorge Hernández-Rodríguez, Alfonso Boyzo, Gabriel Manjarrez-Gutiérre. Development of 5-HT(1B), SERT and thalamo-cortical afferents in early nutrionally restricted rats: an emerging explanation for delayed barrel formation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 2. 2008-05-13. PMID:18207350. |
sert, but not 5-ht(1b) immunoreactivity, was decreased in the primary somatosensory cortex during barrel specification. |
2008-05-13 |
2023-08-12 |
rat |
| Ivett Medina-Aguirre, Gabriel Gutiérrez-Ospina, Jorge Hernández-Rodríguez, Alfonso Boyzo, Gabriel Manjarrez-Gutiérre. Development of 5-HT(1B), SERT and thalamo-cortical afferents in early nutrionally restricted rats: an emerging explanation for delayed barrel formation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 2. 2008-05-13. PMID:18207350. |
this might happen as a secondary effect of decreasing the availability of sert and/or increasing the availability of 5-ht(1b) receptor early in postnatal life. |
2008-05-13 |
2023-08-12 |
rat |
| Lorenzo Leggio, Giovanni Addolorat. Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies. Alcohol and alcoholism (Oxford, Oxfordshire). vol 43. issue 2. 2008-05-08. PMID:18211952. |
serotonin transporter (sert) brain density and neurobiological cloninger subtypes model: a lesson by human autoradiography studies. |
2008-05-08 |
2023-08-12 |
human |
| Roger L Albin, Robert A Koeppe, Nicolaas I Bohnen, Kristine Wernette, Michael A Kilbourn, Kirk A Fre. Spared caudal brainstem SERT binding in early Parkinson's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 3. 2008-04-30. PMID:18073772. |
we used the serotonin transporter (sert) radioligand 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitril (dasb) and positron emission tomography to examine sert distribution and changes in early pd subjects. |
2008-04-30 |
2023-08-12 |
human |
| Luigi Michele Pavone, Pratibha Mithbaokar, Vincenzo Mastellone, Luigi Avallone, Patricia Gaspar, Veeramani Maharajan, Antonio Baldin. Fate map of serotonin transporter-expressing cells in developing mouse heart. Genesis (New York, N.Y. : 2000). vol 45. issue 11. 2008-04-24. PMID:17987662. |
however, the source of serotonin in the cardiovascular system and the role of circulating serotonin and serotonin transporter (sert) in the regulation of cardiovascular functions are still unclear. |
2008-04-24 |
2023-08-12 |
mouse |