| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
we recently developed a rat which lacks the serotonin transporter (sert(-/-)). |
2008-10-14 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
because autonomic responses are often used to measure 5-ht(1a) receptor function, we analysed these responses by examining the effects of a 5-ht(1a) receptor agonist and antagonist under in vivo conditions in the sert(-/-) rat. |
2008-10-14 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
the flesinoxan-induced hypothermia in sert(+/+) rats was blocked by the 5-ht(1a) receptor antagonist [n-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl)-n-(2-pyridinyl) cyclohexane carboxamide 3hcl (way100635). |
2008-10-14 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
it is concluded that the sert knockout rat reveals that 5-ht(1a) receptors modulating stress-induced hyperthermia belong to a population of receptors that differs from that involved in hypothermia. |
2008-10-14 |
2023-08-12 |
rat |
| Giovannella Strappaghetti, Luciano Mastrini, Antonio Lucacchini, Gino Giannaccini, Laura Betti, Laura Fabbrin. Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists. Bioorganic & medicinal chemistry letters. vol 18. issue 18. 2008-10-14. PMID:18760923. |
the ability of these compounds to inhibit the serotonin transporters (sert) was also determined. |
2008-10-14 |
2023-08-12 |
Not clear |
| S O'Mahony, A S B Chua, E M M Quigley, G Clarke, F Shanahan, P W N Keeling, T G Dina. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 6. 2008-10-13. PMID:18194152. |
serotonin metabolites were measured together with the expression of the 5ht1a and serotonin transporter (sert) gene. |
2008-10-13 |
2023-08-12 |
rat |
| S O'Mahony, A S B Chua, E M M Quigley, G Clarke, F Shanahan, P W N Keeling, T G Dina. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 6. 2008-10-13. PMID:18194152. |
in the animal model, an increased turnover of 5ht was found in the brainstem together with a trend toward increased activity of the sert gene. |
2008-10-13 |
2023-08-12 |
rat |
| M Kreilgaard, D G Smith, L T Brennum, C Sánche. Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice. British journal of pharmacology. vol 155. issue 2. 2008-10-08. PMID:18552871. |
here we used a pharmacokinetic/pharmacodynamic (pk/pd) modelling approach to evaluate the predictive validity of 5-hydroxytryptamine (5-ht; serotonin) transporter (sert) occupancy and 5-hydroxytryptophan (5-htp)-potentiated behavioral syndrome induced by 5-ht reuptake inhibitor (sri) antidepressants in mice. |
2008-10-08 |
2023-08-12 |
mouse |
| M A Starr, M E Page, B D Waterhous. MDMA (3,4-methylenedioxymethamphetamine)-mediated distortion of somatosensory signal transmission and neurotransmitter efflux in the ventral posterior medial thalamus. The Journal of pharmacology and experimental therapeutics. vol 327. issue 1. 2008-10-08. PMID:18606872. |
however, mdma interactions with the serotonin transporter protein (sert) are well known. |
2008-10-08 |
2023-08-12 |
rat |
| S G Butler, M J Meega. Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter. Current medicinal chemistry. vol 15. issue 17. 2008-09-26. PMID:18673223. |
the serotonin transporter protein (sert) has been the target for the development of several modern antidepressants with an objective of achieving selectivity over other monoamine transporters, thereby minimising side effects observed in the older generation of tricyclic antidepressants. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
they showed reduced serotonin transporter (sert) binding capacity in the medial frontal cortex, midbrain, and temporal lobe areas. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
the low sert binding reported here and the low serotonin synthesis capacity shown elsewhere may indicate maturation of a lesser number of serotonergic nerve terminals in individuals with autism. |
2008-09-26 |
2023-08-12 |
Not clear |
| Matthäus Willeit, Harald H Sitte, Nikolaus Thierry, Klaus Michalek, Nicole Praschak-Rieder, Peter Zill, Dietmar Winkler, Werner Brannath, Michael B Fischer, Brigitta Bondy, Siegfried Kasper, Ernst A Singe. Enhanced serotonin transporter function during depression in seasonal affective disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 7. 2008-09-24. PMID:17882235. |
the serotonin transporter (5-htt, sert) is a key molecule for the control of synaptic serotonin levels. |
2008-09-24 |
2023-08-12 |
human |
| Anne Marie Jørgensen, Lena Tagmose, Anne Marie M Jørgensen, Sid Topiol, Michael Sabio, Klaus Gundertofte, Klaus P Bøgesø, Günther H Peter. Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site. ChemMedChem. vol 2. issue 6. 2008-09-08. PMID:17405130. |
the serotonin transporter (sert) is one of the neurotransmitter transporters that plays a critical role in the regulation of endogenous amine concentrations and therefore is an important target for therapeutic agents affecting the central nervous system. |
2008-09-08 |
2023-08-12 |
Not clear |
| Julie L Wang, Ajit K Parhi, Shunichi Oya, Brian Lieberman, Mei-Ping Kung, Hank F Kun. 2-(2'-((Dimethylamino)methyl)-4'-(3-[(18)F]fluoropropoxy)-phenylthio)benzenamine for positron emission tomography imaging of serotonin transporters. Nuclear medicine and biology. vol 35. issue 4. 2008-09-05. PMID:18482682. |
a new (18)f ligand, 2-(2'-((dimethylamino)methyl)-4'-(3-[(18)f]fluoropropoxy)-phenylthio)benzenamine ([(18)f]1), for positron emission tomography (pet) imaging of serotonin transporters (sert) was evaluated. |
2008-09-05 |
2023-08-12 |
Not clear |
| Hisayo Sadamoto, Z Serfozo, E It. Localization of serotonin transporter mRNA in the CNS of Lymnaea stagnalis. Acta biologica Hungarica. vol 59 Suppl. 2008-09-05. PMID:18652373. |
the serotonin transporter, sert, is reported as a key molecule that regulates serotonergic neurotransmission. |
2008-09-05 |
2023-08-12 |
Not clear |
| Donatella Marazziti, Francesca Golia, Michela Picchetti, Ellena Pioli, Patrizia Mannari, Francesco Lenzi, Ciro Conversano, Claudia Carmassi, Mario Catena Dell'Osso, Giorgio Consoli, Stefano Baroni, Gino Giannaccini, Giuseppe Zanda, Liliana Dell'Oss. Decreased density of the platelet serotonin transporter in pathological gamblers. Neuropsychobiology. vol 57. issue 1-2. 2008-09-03. PMID:18451636. |
the aim of this study was to investigate the serotonin transporter (sert), by means of the 3h-paroxetine ([3h]-par) binding to platelet membranes, in patients affected by pathological gambling (pg), as compared with a similar group of healthy control subjects. |
2008-09-03 |
2023-08-12 |
human |
| Lucy R Forrest, Yuan-Wei Zhang, Miriam T Jacobs, Joan Gesmonde, Li Xie, Barry H Honig, Gary Rudnic. Mechanism for alternating access in neurotransmitter transporters. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 30. 2008-08-28. PMID:18647834. |
here, we identify the cytoplasmic accessibility pathway of the alternate conformation in a mammalian serotonin transporter (sert) (a member of the same transporter family as leut). |
2008-08-28 |
2023-08-12 |
Not clear |
| O S Brusov, M I Faktor, G P Zlobina, A M Dupin, A B Katasonov, A D Dmitriev, E V Pavlova, A G Beniashvili, M A Morozov. [Platelet serotonergic parameters and clinical symptoms of psychosis in patients with episodic progressive schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 107. issue 4. 2008-08-26. PMID:18379499. |
they confirm the usefulness of testing of platelet 5-ht content and sert immunoreactivity as biological markers of schizophrenic psychoses, in particular for male patents. |
2008-08-26 |
2023-08-12 |
human |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
whereas ssris produce rapid blockade of the serotonin transporter (sert) in vitro and in vivo, the onset of an observable clinical effect takes longer to occur and a variety of pharmacological effects caused by antidepressants have been speculated to be involved either in initiating antidepressant effects and/or enhancing their effects on serotonergic transmission so as to cause clinical improvement. |
2008-08-25 |
2023-08-12 |
mouse |