| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J Owens, Stan Krulewicz, Jeffrey S Simon, David V Sheehan, Michael E Thase, David J Carpenter, Susan J Plott, Charles B Nemerof. Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 13. 2009-02-19. PMID:18418363. |
paroxetine and venlafaxine are potent serotonin transporter (sert) antagonists and weaker norepinephrine transporter (net) antagonists. |
2009-02-19 |
2023-08-12 |
human |
| Robert Adamec, Andrew Holmes, Jacqueline Blundel. Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18550167. |
there is a link between genetic variation in the serotonin (5-ht) transporter (sert) and anxiety in humans, prompting the generation of sert knockout mice. |
2009-02-19 |
2023-08-12 |
mouse |
| Robert Adamec, Andrew Holmes, Jacqueline Blundel. Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18550167. |
this review brings together studies of sert knockout male mice, normal female mice, and different 5-ht receptors in predator stress effects on anxiety. |
2009-02-19 |
2023-08-12 |
mouse |
| Kristian W Kaufmann, Eric S Dawson, L Keith Henry, Julie R Field, Randy D Blakely, Jens Meile. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. vol 74. issue 3. 2009-02-13. PMID:18704946. |
to identify potential determinants of substrate selectivity in serotonin (5-ht) transporters (sert), models of human and drosophila serotonin transporters (hsert, dsert) were built based on the leucine transporter (leut(aa)) structure reported by yamashita et al. |
2009-02-13 |
2023-08-12 |
human |
| Kristian W Kaufmann, Eric S Dawson, L Keith Henry, Julie R Field, Randy D Blakely, Jens Meile. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. vol 74. issue 3. 2009-02-13. PMID:18704946. |
this binding mode places 5-ht deep in the binding pocket of the sert with the 5-position near residue hsert a169/dsert d164 in transmembrane helix 3, the indole nitrogen next to residue y176/y171, and the ethylamine tail under residues f335/f327 and s336/s328 within 4 a of residue d98. |
2009-02-13 |
2023-08-12 |
human |
| Qian L. Cellular and molecular alterations in mice with deficient and reduced serotonin transporters. Molecular neurobiology. vol 34. issue 1. 2009-02-12. PMID:17003521. |
this article focuses on the cellular and molecular alterations in sert knockout mice, including changes in 5-ht concentrations and its metabolism, alterations in 5-ht receptors, impaired hypothalamic-pituitary-adrenal gland axis, developmental changes in the neurons and brain, and influence on other neurotransmitter transporters and receptors. |
2009-02-12 |
2023-08-12 |
mouse |
| Jonathon A Nye, John R Votaw, Nachwa Jarkas, David Purselle, Vernon Camp, James D Bremner, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 12. 2009-02-12. PMID:19038997. |
the novel pet radioligand (11)c-n,n-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine ((11)c-homadam) binds with high affinity and selectively to the serotonin transporter (sert). |
2009-02-12 |
2023-08-12 |
human |
| Una D McCann, Zsolt Szabo, Melin Vranesic, Michael Palermo, William B Mathews, Hayden T Ravert, Robert F Dannals, George A Ricaurt. Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance. Psychopharmacology. vol 200. issue 3. 2009-02-09. PMID:18661256. |
human mdma users have been found to have reduced brain 5-ht transporter (sert) density and cognitive deficits, although it is not known whether these are related. |
2009-02-09 |
2023-08-12 |
human |
| Paul P Bertrand, Xiaoya Hu, John Mach, Rebecca L Bertran. Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 6. 2009-02-09. PMID:18927211. |
although the release of 5-ht is well documented, the contribution of the serotonin reuptake transporter (sert) to the levels and actions of 5-ht in the intestine is unclear. |
2009-02-09 |
2023-08-12 |
rat |
| Paul P Bertrand, Xiaoya Hu, John Mach, Rebecca L Bertran. Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 6. 2009-02-09. PMID:18927211. |
blockade of sert with fluoxetine (1 microm) increased the peak compression-evoked release to 19 +/- 9 microm, and the background levels of 5-ht increased to 11 +/- 7 microm (p < 0.05, n = 7). |
2009-02-09 |
2023-08-12 |
rat |
| Paul P Bertrand, Xiaoya Hu, John Mach, Rebecca L Bertran. Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 6. 2009-02-09. PMID:18927211. |
these data suggest that sert plays an important role in the modulation of 5-ht concentrations that reach intestinal 5-ht receptors. |
2009-02-09 |
2023-08-12 |
rat |
| Pedro Gonçalves, João R Araújo, Fátima Marte. The effect of high glucose on SERT, the human plasmalemmal serotonin transporter. Nutritional neuroscience. vol 11. issue 6. 2009-02-09. PMID:19000377. |
the effect of high glucose on sert, the human plasmalemmal serotonin transporter. |
2009-02-09 |
2023-08-12 |
human |
| Pedro Gonçalves, João R Araújo, Fátima Marte. The effect of high glucose on SERT, the human plasmalemmal serotonin transporter. Nutritional neuroscience. vol 11. issue 6. 2009-02-09. PMID:19000377. |
the aim of this work was to investigate the effect of short- and long-term high-glucose exposure on the plasmalemmal serotonin transporter (sert)-mediated uptake of [(3)h]-serotonin (5-ht) by caco-2 cells. |
2009-02-09 |
2023-08-12 |
human |
| Sylvie Mavel, Johnny Vercouillie, Lucette Garreau, Tiziana Raguza, Aina Westrheim Ravna, Sylvie Chalon, Denis Guilloteau, Patrick Emon. Docking study, synthesis, and in vitro evaluation of fluoro-MADAM derivatives as SERT ligands for PET imaging. Bioorganic & medicinal chemistry. vol 16. issue 19. 2009-01-30. PMID:18793858. |
in order to predict affinity of new diphenylsulfides for the serotonin transporter (sert), a molecular modeling model was used to compare potential binding affinity of new compounds with known potent ligands. |
2009-01-30 |
2023-08-12 |
Not clear |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Vernon M Camp, Eugene J Malveaux, John R Votaw, Leonard Howell, Michael J Owens, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053782. |
the meta-vinylhalide fluoroalkyl ester nortropanes 1-4 were synthesized as ligands of the serotonin transporter (sert) for use as positron emission tomography (pet) imaging agents. |
2009-01-22 |
2023-08-12 |
monkey |
| Aroldo Cupello, Fabio Bandini, Claudio Albano, Emilio Favale, Roberta Marchese, Simona Scarrone, Carlo Trompett. Catatonic features in major depression relieved by electroconvulsive treatment: parallel evaluation of the status of platelet serotonin transporter. The International journal of neuroscience. vol 118. issue 10. 2009-01-21. PMID:18788029. |
the aim of this research was to follow parallelly the clinical status of a patient and the dynamics of the serotonin transporter (sert), a likely player in the effect of electroconvulsive treatment (ect), a powerful tool against deep depression. |
2009-01-21 |
2023-08-12 |
Not clear |
| E J Vallender, C M Priddy, S Hakim, H Yang, G-L Chen, G M Mille. Functional variation in the 3' untranslated region of the serotonin transporter in human and rhesus macaque. Genes, brain, and behavior. vol 7. issue 6. 2009-01-16. PMID:18445138. |
among genes involved in the system, the serotonin transporter (sert) is integral and has been repeatedly shown to be associated with disease as well as being a primary drug target. |
2009-01-16 |
2023-08-12 |
human |
| Marcia A Ciccone, Miranda Timmons, Anthony Phillips, Michael W Quic. Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18602929. |
when not bound to syntaxin 1a, sert shows both substrate-independent na(+) fluxes and substrate-dependent na(+) fluxes of variable stoichiometry; these fluxes are eliminated in the presence of syntaxin 1a as na(+) flux becomes strictly coupled to 5ht uptake. |
2009-01-15 |
2023-08-12 |
Not clear |
| Nada Bozina, Alma Mihaljevic Peles, Marina Sagud, Hrvoje Bilusic, Miro Jakovljevi. Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 9. issue 3. 2009-01-14. PMID:17853254. |
we investigated the relationships between ls promoter (sertpr) and ls intron2 (sertin2) genetic variants of serotonin transporter (sert) polymorphisms with treatment response in 130 patients with major depressive disorder (mdd) treated with paroxetine (20 mg/day) for 6 weeks. |
2009-01-14 |
2023-08-12 |
human |
| Anu Koskela, Tomi Kauppinen, Anna Keski-Rahkonen, Elina Sihvola, Jaakko Kaprio, Aila Rissanen, Aapo Ahone. Brain serotonin transporter binding of [123I]ADAM: within-subject variation between summer and winter data. Chronobiology international. vol 25. issue 5. 2009-01-14. PMID:18780196. |
we investigated within-subject seasonal variation in brain serotonin transporter (sert) binding with the sert-ligand [(123)i]adam and single photon emission computed tomography (spect) in 12 healthy individuals. |
2009-01-14 |
2023-08-12 |
Not clear |