| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uta Funke, Steffen Fischer, Achim Hiller, Matthias Scheunemann, Winnie Deuther-Conrad, Peter Brust, Jörg Steinbac. 3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: chemical synthesis, evaluation in vitro and radiofluorination. Bioorganic & medicinal chemistry letters. vol 18. issue 16. 2008-11-24. PMID:18644726. |
aminocyclohexyl indoles bind with high affinity and specificity toward the serotonin transporter (sert). |
2008-11-24 |
2023-08-12 |
Not clear |
| Ruth Kohen, Kevin C Cain, Pamela H Mitchell, Kyra Becker, Ann Buzaitis, Steven P Millard, Grace P Navaja, Linda Teri, David Tirschwell, Richard Veit. Association of serotonin transporter gene polymorphisms with poststroke depression. Archives of general psychiatry. vol 65. issue 11. 2008-11-18. PMID:18981341. |
polymorphisms of the serotonin transporter gene (sert) have been associated with mental illness. |
2008-11-18 |
2023-08-12 |
Not clear |
| A Anitha, Kazuhiko Nakamura, Kazuo Yamada, Shiro Suda, Ismail Thanseem, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Keita Koizumi, Haruhiro Higashida, Nori Takei, Takeo Yoshikawa, Norio Mor. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18270976. |
serotonin transporter (sert) modulates serotonin levels, and is a major therapeutic target in autism. |
2008-11-17 |
2023-08-12 |
drosophila_melanogaster |
| Seth Y Ablordeppey, Ramazan Altundas, Barbara Bricker, Xue Y Zhu, Eyunni V K Suresh Kumar, Tanise Jackson, Abdul Khan, Bryan L Rot. Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. Bioorganic & medicinal chemistry. vol 16. issue 15. 2008-11-07. PMID:18595716. |
compound 13 was evaluated for its binding affinities at da subtype receptors, 5ht subtype receptors, h-1, m-1 receptors and at net, dat, and sert transporters. |
2008-11-07 |
2023-08-12 |
mouse |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
to assess 5-ht axon terminal integrity after mdma treatment, the density of 5-ht transporter (sert) binding sites was measured by quantitative autoradiography using [125i]rti-55 ((-)-2beta-carbomethoxy-3 beta-(4-iodophenyl) tropane) ((125)i-rti-55) as a ligand. |
2008-11-05 |
2023-08-12 |
rat |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
in contrast, tph2 mrna levels were significantly increased by 24% in the mid dr and by 12% in the caudal dr. mdma treatment significantly decreased (125)i-rti-55 labeled sert binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-ht terminals. |
2008-11-05 |
2023-08-12 |
rat |
| Judith R Homberg, Ruud van den Bos, Esther den Heijer, Remco Suer, Edwin Cuppe. Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18534635. |
furthermore, we tested female homozygous (sert(-/-)) and heterozygous (sert(+/-)) serotonin transporter knockout rats in a rodent version of the igt. |
2008-11-05 |
2023-08-12 |
human |
| Kelly Lengyel, Rick Pieschl, Todd Strong, Thaddeus Molski, Gail Mattson, Nicholas J Lodge, Yu-Wen L. Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance. Neuropharmacology. vol 55. issue 1. 2008-11-05. PMID:18538356. |
the goal of this study was to develop and validate ex vivo binding assays for serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, and to use these assays to evaluate the binding site occupancy of triple and double monoamine reuptake inhibitors in rat brains. |
2008-11-05 |
2023-08-12 |
rat |
| Prem Prakash Tripathi, Luca Giovanni Di Giovannantonio, Alessandro Viegi, Wolfgang Wurst, Antonio Simeone, Yuri Bozz. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784307. |
conversely, sert (5-ht transporter) levels were decreased in conditional mutant brains. |
2008-11-03 |
2023-08-12 |
mouse |
| A P M Kerckhoffs, J J M Ter Linde, L M A Akkermans, M Samso. Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18363639. |
gene transcripts of par-2, trypsinogen iv, tph-1, sert (serotonin transport protein) and serotonin (5-ht(3)) subunits were quantified using real-time pcr and 5-ht content was measured by elisa. |
2008-10-27 |
2023-08-12 |
human |
| A P M Kerckhoffs, J J M Ter Linde, L M A Akkermans, M Samso. Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 8. 2008-10-27. PMID:18363639. |
increased sert expression and mucosal 5-ht content in ibs suggest higher 5-ht availability. |
2008-10-27 |
2023-08-12 |
human |
| Aloke K Dutta, Balaram Ghosh, Swati Biswas, Maarten E A Reit. D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18561912. |
one of our lead molecules, d-161 exhibited triple monoamine transporter inhibitory activity with the highest affinity for norepinephrine transporter (net) followed by its affinity for serotonin transporter (sert) and dopamine transporter (dat). |
2008-10-24 |
2023-08-12 |
mouse |
| Wei Ni, Huawei Zhou, Jessica Diaz, Dennis L Murphy, Joseph R Haywood, Stephanie W Watt. Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18573249. |
we hypothesized that lack of a functional serotonin transporter (sert) would increase basal blood pressure and enhance the development of deoxycorticosterone acetate (doca)-salt hypertension compared to wild type (wt) controls. |
2008-10-24 |
2023-08-12 |
mouse |
| Meagan M Costedio, Matthew D Coates, Amy B Danielson, Thomas R Buttolph, Hagen J Blaszyk, Gary M Mawe, Neil H Hyma. Serotonin signaling in diverticular disease. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 12. issue 8. 2008-10-23. PMID:18491196. |
the key elements of 5-ht signaling including content, release, and 5-ht transporter (sert) expression were analyzed. |
2008-10-23 |
2023-08-12 |
human |
| O Mnie-Filali, M El Mansari, H Scarna, L Zimmer, C Sánchez, N Haddjer. [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter]. L'Encephale. vol 33. issue 6. 2008-10-23. PMID:18789789. |
the exact mechanism by which r-citalopram exerts its action is not yet fully defined; however, an allosteric interaction between the enantiomers and the 5-ht transporter (sert) has been proposed. |
2008-10-23 |
2023-08-12 |
rat |
| O Mnie-Filali, M El Mansari, H Scarna, L Zimmer, C Sánchez, N Haddjer. [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter]. L'Encephale. vol 33. issue 6. 2008-10-23. PMID:18789789. |
in this context, in vitro studies have revealed the existence of at least two binding sites on sert: (1) a primary high-affinity binding site or orthosteric site that mediates the inhibition of 5-ht reuptake and (2) an allosteric low-affinity binding site that modulates the binding of ligands at the primary site. |
2008-10-23 |
2023-08-12 |
rat |
| O Mnie-Filali, M El Mansari, H Scarna, L Zimmer, C Sánchez, N Haddjer. [Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter]. L'Encephale. vol 33. issue 6. 2008-10-23. PMID:18789789. |
thus, escitalopram exerts a stabilizing effect on this association to sert, resulting in an effective inhibition of 5-ht reuptake activity. |
2008-10-23 |
2023-08-12 |
rat |
| Soili M Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtone. Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neuroscience letters. vol 441. issue 3. 2008-10-20. PMID:18588943. |
we examined the striatum dopamine (dat) and midbrain serotonin transporter (sert) binding of [123i] nor-beta-cit in dd patients (n=8) and compared it to that in md patients (n=11) and healthy controls (n=19). |
2008-10-20 |
2023-08-12 |
Not clear |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
stress-induced hyperthermia and basal body temperature are mediated by different 5-ht(1a) receptor populations: a study in sert knockout rats. |
2008-10-14 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Berend Olivier, Judith R Homberg, Edwin Cuppen, Bart A Ellenbroe. Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats. European journal of pharmacology. vol 590. issue 1-3. 2008-10-14. PMID:18606402. |
the serotonin transporter (sert) regulates the serotonin homeostasis in the synapse. |
2008-10-14 |
2023-08-12 |
rat |