| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scot Mente, Randall Gallaschun, Anne Schmidt, Lorrie Lebel, Michelle Vanase-Frawley, Anton Flir. Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities. Bioorganic & medicinal chemistry letters. vol 18. issue 23. 2009-01-09. PMID:18948001. |
using this methodology, intuitive qsar relationships were found for the three biological activities with r(2) values of 0.73, 0.45, and 0.58 for 5ht(2a), sert, and herg activities. |
2009-01-09 |
2023-08-12 |
Not clear |
| Subbu Apparsundaram, Daniel J Stockdale, Robert A Henningsen, Marcos E Milla, Renee S Marti. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18801947. |
although several antidepressants (including fluoxetine, imipramine, citalopram, venlafaxine, and duloxetine) are known to inhibit the serotonin transporter (sert), whether or not these molecules compete with 5-hydroxytryptamine (serotonin) (5-ht) for binding to sert has remained controversial. |
2009-01-05 |
2023-08-12 |
human |
| Subbu Apparsundaram, Daniel J Stockdale, Robert A Henningsen, Marcos E Milla, Renee S Marti. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18801947. |
the equilibrium dissociation constant of 5-ht and sert inhibitors were also derived using scatchard analysis of the data set, and they were found to be comparable with the data obtained using the cheng-prusoff relationship. |
2009-01-05 |
2023-08-12 |
human |
| Subbu Apparsundaram, Daniel J Stockdale, Robert A Henningsen, Marcos E Milla, Renee S Marti. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. The Journal of pharmacology and experimental therapeutics. vol 327. issue 3. 2009-01-05. PMID:18801947. |
our studies establish a reference framework that will contribute to ongoing efforts to understand ligand binding modes at sert by demonstrating that 5-ht and the sert inhibitors tested bind to the serotonin transporter in a competitive manner. |
2009-01-05 |
2023-08-12 |
human |
| William H J Norton, Anja Folchert, Laure Bally-Cui. Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain. The Journal of comparative neurology. vol 511. issue 4. 2008-12-30. PMID:18839395. |
our analysis of serotonin transporter (sert)-encoding genes also identifies parallel genetic pathways used to build the 5-ht system in zebrafish. |
2008-12-30 |
2023-08-12 |
zebrafish |
| Subhash M Nadgir, Manish Malviy. In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18437564. |
serotonin transporters (sert) have been implicated in the etiology of depression and drugs acting on sert can be effective in treating depression. |
2008-12-12 |
2023-08-12 |
rat |
| Yunhang Guo, Xiangji Chen, Hongmei Jia, Xinmin Ji, Boli Li. Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 66. issue 12. 2008-12-10. PMID:18684634. |
imaging of serotonin transporter (sert) by positron emission tomography (pet) or single-photon emission-computed tomography (spect) in humans would provide useful information in diagnosis and therapy of several neurodegenerative and neuropsychiatric disorders. |
2008-12-10 |
2023-08-12 |
mouse |
| Kuo-Hsing Ma, Wen-Sheng Huang, San-Yuan Huang, Cheng-Yi Cheng, Ching-Yuan Chen, Lie-Hang Shen, Jiang-Chuan Liu, Ying-Kai F. Imaging serotonin transporters using [123I]ADAM SPECT in a parkinsonian primate model. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 66. issue 12. 2008-12-10. PMID:18703341. |
the purpose of this study was to investigate differences in the serotonin transport system between normal and parkinsonian monkeys using 2-([2-([di-methylamino]methyl)phenyl]thio)-5-[(123)i] iodophenyl-amine([(123)i]adam), a serotonin transporters (sert) radioligand. |
2008-12-10 |
2023-08-12 |
human |
| Stacy L Sell, Rebecca M Craft, Patricia K Seitz, Sonja J Stutz, Kathryn A Cunningham, Mary L Thoma. Estradiol-sertraline synergy in ovariectomized rats. Psychoneuroendocrinology. vol 33. issue 8. 2008-12-09. PMID:18650020. |
this study investigated estradiol (e(2)) modulation of the antidepressant effects of a selective serotonin (5-ht) reuptake inhibitor (ssri; sertraline) and a tricyclic antidepressant (imipramine) as measured by the forced swim test (fst) followed by assessment of gene and protein expression for the 5-ht transporter (sert) and multiple 5-ht receptors. |
2008-12-09 |
2023-08-12 |
rat |
| Stacy L Sell, Rebecca M Craft, Patricia K Seitz, Sonja J Stutz, Kathryn A Cunningham, Mary L Thoma. Estradiol-sertraline synergy in ovariectomized rats. Psychoneuroendocrinology. vol 33. issue 8. 2008-12-09. PMID:18650020. |
however, in vehicle-treated rats, e(2) increased midbrain sert mrna expression, with no effect on midbrain mrna for the 5-ht receptors. |
2008-12-09 |
2023-08-12 |
rat |
| Jerrold S Meyer, Brian J Piper, Valerie E Vancolli. Development and characterization of a novel animal model of intermittent MDMA ("Ecstasy") exposure during adolescence. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991859. |
adult animals treated with high doses of mdma ("ecstasy") either on a single day or for several consecutive days show numerous behavioral changes as well as persistent reductions in brain serotonin (5-ht) concentrations and 5-ht transporter (sert) protein expression. |
2008-12-09 |
2023-08-12 |
human |
| Richard B Rothman, Dorota Zolkowska, Michael H Bauman. Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991872. |
however, certain 5-ht transporter (sert) substrates are associated with development of idiopathic pulmonary arterial hypertension (ipah) and valvular heart disease (vhd). |
2008-12-09 |
2023-08-12 |
rat |
| Richard B Rothman, Dorota Zolkowska, Michael H Bauman. Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991872. |
according to the "5-ht hypothesis," sert substrates increase the risk for developing ipah and vhd by increasing plasma 5-ht. |
2008-12-09 |
2023-08-12 |
rat |
| Richard B Rothman, Dorota Zolkowska, Michael H Bauman. Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991872. |
to test this hypothesis directly, we determined the effects of acute and chronic fenfluramine, and other sert ligands, on plasma 5-ht in male rats. |
2008-12-09 |
2023-08-12 |
rat |
| Richard B Rothman, Dorota Zolkowska, Michael H Bauman. Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991872. |
acute injection of fenfluramine or other sert substrates caused large (up to 24-fold) dose-dependent increases in plasma 5-ht. |
2008-12-09 |
2023-08-12 |
rat |
| Luigi Michele Pavone, Anna Spina, Roberta Lo Muto, Dionea Santoro, Vincenzo Mastellone, Luigi Avallon. Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18854178. |
heart valve cardiomyocytes of mouse embryos express the serotonin transporter sert. |
2008-12-05 |
2023-08-12 |
mouse |
| Luigi Michele Pavone, Anna Spina, Roberta Lo Muto, Dionea Santoro, Vincenzo Mastellone, Luigi Avallon. Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18854178. |
multiple evidence demonstrate a role for serotonin and its transporter sert in heart valve development and disease. |
2008-12-05 |
2023-08-12 |
mouse |
| Hilary R Smith, Linda J Porrin. The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Brain structure & function. vol 213. issue 1-2. 2008-12-02. PMID:18283492. |
the serotonin transporter (sert) had the greatest overall degree of labeling of the three markers, and was characterized by substantial inter-species variability in its relative distribution. |
2008-12-02 |
2023-08-12 |
human |
| Rocchina Colucci, Corrado Blandizzi, Massimo Bellini, Narcisa Ghisu, Marcello Tonini, Mario Del Tacc. The genetics of the serotonin transporter and irritable bowel syndrome. Trends in molecular medicine. vol 14. issue 7. 2008-11-26. PMID:18550438. |
serotonin transporter (sert) mediates the intracellular reuptake of released serotonin, thus regulating its biological functions. |
2008-11-26 |
2023-08-12 |
human |
| M Geldof, J I Freijer, L van Beijsterveldt, X Langlois, M Danho. Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex. British journal of pharmacology. vol 154. issue 6. 2008-11-25. PMID:18493251. |
the pharmacokinetic-pharmacodynamic (pk-pd) correlation of fluvoxamine 5-ht transporter (sert) occupancy was determined in rat frontal cortex ex vivo. |
2008-11-25 |
2023-08-12 |
rat |