| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson, Jamin Boggs, Lisa K Dvorak, Michael A Letavic, Bruce E Maryanoff, Nicholas I Carruthers, Pascal Bonaventure, Timothy W Lovenber. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18499098. |
triple reuptake inhibitors, which block the serotonin transporter (sert), norepinephrine transporter (net) and dopamine transporter (dat) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. |
2008-08-25 |
2023-08-12 |
mouse |
| Christopher D Verrico, Laurie Lynch, Michele A Fahey, Ashley-Kay Fryer, Gregory M Miller, Bertha K Madra. MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. Journal of psychopharmacology (Oxford, England). vol 22. issue 2. 2008-08-18. PMID:18308800. |
we postulated that mdma will compromise executive function in primates and that an inhibitor of the serotonin transporter (sert) and the norepinephrine transporter (net) but not the dopamine (dat) transporter, will prevent impairment. |
2008-08-18 |
2023-08-12 |
human |
| Marian Geldof, Jan I Freijer, Lambertus A Peletier, Ludy van Beijsterveldt, Meindert Danho. Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 33. issue 3. 2008-08-12. PMID:18207708. |
in the model, ssris increase synaptic 5-ht concentrations by reversible blockade of the sert in a direct concentration-dependent manner, while the 5-ht response is attenuated by negative feedback via 5-ht autoreceptors. |
2008-08-12 |
2023-08-12 |
rat |
| N van Lelyveld, J T Linde, M Schipper, M Samso. Candidate genotypes associated with functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 7. 2008-08-12. PMID:18331431. |
polymorphisms in genes encoding the serotonin receptor type three a subunit (htr3a), the serotonin transporter (sert) and the g-protein beta3 subunit (gnb3) were analysed. |
2008-08-12 |
2023-08-12 |
Not clear |
| Rainer Hinz, Sudhakar Selvaraj, N Venkatesha Murthy, Zubin Bhagwagar, Matthew Taylor, Philip J Cowen, Paul M Grasb. Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 8. 2008-08-12. PMID:18478022. |
the positron emission tomography (pet) ligand [(11)c]dasb is currently the most widely used imaging agent for quantitative studies of the serotonin transporter (sert) in human brain. |
2008-08-12 |
2023-08-12 |
human |
| Vishakantha Murthy, Thomas J Martin, Susy Kim, Huw M L Davies, Steven R Childer. In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain. The Journal of pharmacology and experimental therapeutics. vol 326. issue 2. 2008-08-12. PMID:18492949. |
previous studies have shown that the phenylisothiocyanate tropane analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-[4-isothiocyanato)benzyl]nortropane (hd-205) binds covalently to dopamine and serotonin transporters (dat and sert, respectively) in rat brain membranes (biochem pharmacol 74:336-344, 2007). |
2008-08-12 |
2023-08-12 |
rat |
| Boris Mlinar, Simona Mascalchi, Raffaella Morini, Filippo Giachi, Renato Corradett. MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17653110. |
block of serotonin transporter (sert) with citalopram or 5-ht depletion with (+/-)-p-chlorophenylalanine pretreatment partially inhibited the esp mdma. |
2008-08-07 |
2023-08-12 |
human |
| Boris Mlinar, Simona Mascalchi, Raffaella Morini, Filippo Giachi, Renato Corradett. MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17653110. |
block of both sert and ne transporter prevented esp mdma, indicating its dependence on release of both 5-ht and ne. |
2008-08-07 |
2023-08-12 |
human |
| Dean F Wong, James R Brasić, Harvey S Singer, David J Schretlen, Hiroto Kuwabara, Yun Zhou, Ayon Nandi, Marika A Maris, Mohab Alexander, Weiguo Ye, Olivier Rousset, Anil Kumar, Zsolt Szabo, Albert Gjedde, Anthony A Grac. Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17987065. |
we also measured the brain distribution and bp of serotonin 5-ht2a receptors (5-ht2ar), and serotonin transporter (sert) bp, in 11 subjects with ts and 10 normal control subjects. |
2008-08-07 |
2023-08-12 |
human |
| Dean F Wong, James R Brasić, Harvey S Singer, David J Schretlen, Hiroto Kuwabara, Yun Zhou, Ayon Nandi, Marika A Maris, Mohab Alexander, Weiguo Ye, Olivier Rousset, Anil Kumar, Zsolt Szabo, Albert Gjedde, Anthony A Grac. Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17987065. |
the finding of decreased sert bp, and the possible elevation in 5-ht2ar in individuals with ts who had increased da rel, suggest a condition of increased phasic da rel modulated by low 5-ht in concomitant ocd. |
2008-08-07 |
2023-08-12 |
human |
| Keith A Young, Willy L Bonkale, Leigh A Holcomb, Paul B Hicks, Dwight C Germa. Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. The British journal of psychiatry : the journal of mental science. vol 192. issue 4. 2008-08-07. PMID:18378990. |
the 5httlpr genetic variant of the serotonin transporter gene (sert or 5-htt), which is comprised of a short (sert-s) and a long (sert-l) allele, is associated with major depressive disorder and post-traumatic brain disorder. |
2008-08-07 |
2023-08-12 |
Not clear |
| N van Lelyveld, J Ter Linde, M Schipper, M Samso. Serotonergic signalling in the stomach and duodenum of patients with gastroparesis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18208480. |
neuroendocrine cells, specifically 5-ht producing cells, were counted after immunohistochemistry, and non-neuronal mrna expression levels of tryptophan hydroxylase (tph)-1, 5-ht transport protein (sert), 5-ht3 and 5-ht4 receptor were quantified by real time rt-pcr. |
2008-08-06 |
2023-08-12 |
Not clear |
| N van Lelyveld, J Ter Linde, M Schipper, M Samso. Serotonergic signalling in the stomach and duodenum of patients with gastroparesis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18208480. |
no difference in expression of tph-1 (rate limiting enzyme in 5-ht biosynthetic pathway) and sert (responsible for 5-ht uptake) was found between patients and controls (p > 0.05). |
2008-08-06 |
2023-08-12 |
Not clear |
| Morena Zusso, Patrizia Debetto, Diego Guidolin, Massimo Barbierato, Hari Manev, Pietro Giust. Fluoxetine-induced proliferation and differentiation of neural progenitor cells isolated from rat postnatal cerebellum. Biochemical pharmacology. vol 76. issue 3. 2008-08-04. PMID:18573488. |
rt-pcr and immunostaining revealed the expression of serotonin transporter (sert), 5ht(1a) receptors, tryptophan hydroxylase (tph), and serotonin (5ht). |
2008-08-04 |
2023-08-12 |
human |
| Anu K Koskela, Salla Kaurijoki, Kirsi H Pietiläinen, Leila Karhunen, Ullamari Pesonen, Jyrki T Kuikka, Jaakko Kaprio, Aila Rissane. Serotonin transporter binding and acquired obesity -- an imaging study of monozygotic twin pairs. Physiology & behavior. vol 93. issue 4-5. 2008-07-31. PMID:18177905. |
we studied the association between obesity and 5-ht by investigating the brain serotonin transporter (sert) binding in 16 monozygotic twin pairs with varying body mass index (bmi) differences. |
2008-07-31 |
2023-08-12 |
human |
| Holly Jarrell, Jackie B Hoffman, Jay R Kaplan, Sarah Berga, Becky Kinkead, Mark E Wilso. Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys. Physiology & behavior. vol 93. issue 4-5. 2008-07-31. PMID:18190935. |
the present study evaluated the extent to which polymorphisms in the gene encoding the serotonin reuptake transporter (5httlpr or sert) modulated physiologic responses to the imposition of psychosocial stress (social reorganization and subordinate social status) in female rhesus monkeys. |
2008-07-31 |
2023-08-12 |
monkey |
| Ilya Ayzenberg, Mark Obermann, Mark Oberman, Kirsten Leineweber, Leonora Franke, Min-Suk Yoon, Hans-Christoph Diener, Zaza Katsarav. Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans. The journal of headache and pain. vol 9. issue 2. 2008-07-29. PMID:18330504. |
we investigated the effect of chronic administration of different pain medications on the activity of the serotonin transporter (sert) in patients with medication overuse headache (moh). |
2008-07-29 |
2023-08-12 |
human |
| Ilya Ayzenberg, Mark Obermann, Mark Oberman, Kirsten Leineweber, Leonora Franke, Min-Suk Yoon, Hans-Christoph Diener, Zaza Katsarav. Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans. The journal of headache and pain. vol 9. issue 2. 2008-07-29. PMID:18330504. |
the data demonstrate a transient increase of sert activity in patients with analgesic and triptan induced moh but do not allow to differentiate whether the increase of serotonin uptake is caused by regular intake of analgesics or triptans or is a consequence of frequent headache attacks. |
2008-07-29 |
2023-08-12 |
human |
| Yvonne Dempsie, Ian Morecroft, David J Welsh, Neil A MacRitchie, Nigel Herold, Lynn Loughlin, Margaret Nilsen, Andrew J Peacock, Anthony Harmar, Michael Bader, Margaret R MacLea. Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. Circulation. vol 117. issue 22. 2008-07-23. PMID:18506000. |
here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; tph1(-/-) mice) or overexpressing the gene for the human serotonin transporter (sert; sert(+) mice) to investigate this further. |
2008-07-23 |
2023-08-12 |
mouse |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
human studies have shown that a reduction of 5-ht transporter (sert) increases the vulnerability for anxiety and depression. |
2008-07-21 |
2023-08-12 |
human |