| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
for that reason we hypothesized that homozygous 5-ht transporter knockout rat (sert(-/-)) models, especially female, are valuable and reliable animal models for humans with an increased vulnerability for anxiety- and depression-related disorders. |
2008-07-21 |
2023-08-12 |
human |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
behavioral testing revealed that male and female sert(-/-) rats spent less time in the center of the open field and spent less time on the open arm of the elevated plus maze compared with wild-type 5-ht transporter knockout rats (sert(+/+)). |
2008-07-21 |
2023-08-12 |
human |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
neurochemically, basal extracellular 5-ht levels were elevated to a similar extent in male and female sert(-/-) rats, which was not influenced by the selective 5-ht reuptake inhibitor citalopram. |
2008-07-21 |
2023-08-12 |
human |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
5-ht immunostaining revealed no difference between sert(+/+) and sert(-/-) rats in the dorsal raphe nuclei, in both males and females. |
2008-07-21 |
2023-08-12 |
human |
| Kazumi Nomura, Oscar Castanon-Cervantes, Alec Davidson, Chiaki Fukuhar. Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts. Life sciences. vol 82. issue 23-24. 2008-07-21. PMID:18482738. |
we found that mrna of the serotonin transporter (sert), a target of ssris, was expressed in rat-1 fibroblasts. |
2008-07-21 |
2023-08-12 |
mouse |
| Thorsten Lau, Sandra Horschitz, Stefan Berger, Dusan Bartsch, Patrick Schlos. Antidepressant-induced internalization of the serotonin transporter in serotonergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 6. 2008-07-16. PMID:18216289. |
we have analyzed cellular serotonin transporter (sert) expression on exposure to the selective serotonin reuptake inhibitor citalopram in serotonergic neurons expressing the native sert allele in its natural surroundings. |
2008-07-16 |
2023-08-12 |
Not clear |
| Bhavik Anil Pate. Continuous amperometric detection of co-released serotonin and melatonin from the mucosa in the ileum. The Analyst. vol 133. issue 4. 2008-07-16. PMID:18365122. |
application of the serotonin transporter (sert) inhibitor, fluoxetine, elevated the 5-ht but not the mel signal. |
2008-07-16 |
2023-08-12 |
rabbit |
| Ling-Wei Hsin, Li-Te Chang, Richard B Rothman, Christina M Dersch, Arthur E Jacobson, Kenner C Ric. Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters. Journal of medicinal chemistry. vol 51. issue 9. 2008-07-09. PMID:18393401. |
novel derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (gbr 12909, 1) and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (gbr 12935, 2) with various substituents in positions c2 and c3 of the phenylpropyl side chain were synthesized and evaluated for their ability to bind to the dopamine transporter (dat) and the serotonin transporter (sert). |
2008-07-09 |
2023-08-12 |
Not clear |
| Sawako Kinouchi, Jun-Ichi Iga, Shu-Ichi Ueno, Ken Yamauchi, Shusuke Numata, Hongwei Song, Satsuki Sumitani, Sumiko Shibuya-Tayoshi, Mari Haku, Toshiyuki Yasui, Minoru Irahara, Kyoko Morita, Kazuhito Rokutan, Tetsuro Ohmor. FKBP5, SERT and COMT mRNA expressions in the peripheral leukocytes during menstruation cycle in healthy reproductive females. Neuroscience letters. vol 434. issue 1. 2008-07-03. PMID:18291582. |
the fkbp5 (fk506-binding protein gene), sert (serotonin transporter gene) and comt (catechol-o-methyltransferase gene) mrna expressions in the leukocytes were determined with hormonal data. |
2008-07-03 |
2023-08-12 |
human |
| Susanne Jørgensen, Elsebet Østergaard Nielsen, Dan Peters, Tino Dyhrin. Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity. Journal of neuroscience methods. vol 169. issue 1. 2008-06-23. PMID:18222006. |
pre-synaptic dopamine, norepinephrine and serotonin transporters (dat, net and sert) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. |
2008-06-23 |
2023-08-12 |
Not clear |
| Sandra Horschitz, Thorsten Lau, Patrick Schlos. Glycine residues G338 and G342 are important determinants for serotonin transporter dimerisation and cell surface expression. Neurochemistry international. vol 52. issue 4-5. 2008-06-20. PMID:17949855. |
in order to investigate, whether this motif is important for proper expression and function of the serotonin transporter (sert), we have analysed the effect of mutating the respective glycine residues gly338 and gly342 to valine upon transient expression of the respective cdnas in hek293 cells. |
2008-06-20 |
2023-08-12 |
Not clear |
| A Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J Geddes, Donald M Kuhn, Stephanie W Watt. A serotonergic system in veins: serotonin transporter-independent uptake. The Journal of pharmacology and experimental therapeutics. vol 325. issue 3. 2008-06-16. PMID:18322152. |
the presence of mao-a and the 5-ht transporter (sert) in vc was observed by immunohistochemistry and western analysis. |
2008-06-16 |
2023-08-12 |
rat |
| A Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J Geddes, Donald M Kuhn, Stephanie W Watt. A serotonergic system in veins: serotonin transporter-independent uptake. The Journal of pharmacology and experimental therapeutics. vol 325. issue 3. 2008-06-16. PMID:18322152. |
however, 5-ht uptake was not inhibited by the sert inhibitors fluoxetine and/or fluvoxamine in vc and jv, as opposed to the inhibition in ra and ca. |
2008-06-16 |
2023-08-12 |
rat |
| A Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J Geddes, Donald M Kuhn, Stephanie W Watt. A serotonergic system in veins: serotonin transporter-independent uptake. The Journal of pharmacology and experimental therapeutics. vol 325. issue 3. 2008-06-16. PMID:18322152. |
moreover, studies performed in vc from mutant rats lacking sert showed no differences in 5-ht uptake compared with vc from wild type. |
2008-06-16 |
2023-08-12 |
rat |
| Manoj Mishra, Rohit Kolhatkar, Juan Zhen, Ingrid Parrington, Maarten E A Reith, Aloke K Dutt. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249549. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin (5-ht) transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2008-06-13 |
2023-08-12 |
Not clear |
| Kasper Severinsen, Steffen Sinning, Heidi Kaastrup Müller, Ove Wibor. Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18266934. |
however, despite extensive efforts little is known about the protein-ligand interactions of serotonin transporter (sert) and inhibitors. |
2008-06-12 |
2023-08-12 |
human |
| Jennifer D Lundgren, Andrew B Newberg, Kelly C Allison, Nancy A Wintering, Karl Ploessl, Albert J Stunkar. 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report. Psychiatry research. vol 162. issue 3. 2008-06-10. PMID:18281200. |
this pilot spect (single photon emission computed tomography) study compared the serotonin transporter (sert) uptake ratios of night eaters with those of healthy controls. |
2008-06-10 |
2023-08-12 |
Not clear |
| Prashant S Kharkar, Maarten E A Reith, Aloke K Dutt. Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors. Journal of computer-aided molecular design. vol 22. issue 1. 2008-06-03. PMID:18060532. |
three-dimensional quantitative structure-activity relationship (3d qsar) using comparative molecular field analysis (comfa) was performed on a series of substituted tetrahydropyran (thp) derivatives possessing serotonin (sert) and norepinephrine (net) transporter inhibitory activities. |
2008-06-03 |
2023-08-12 |
Not clear |
| Chi-Jiun Peng, Ya-Yao Huang, Wen-Sheng Huang, Chyng-Yann Shiu. An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 66. issue 5. 2008-06-03. PMID:18226534. |
n,n-dimethyl-2-(2-amino-4-[(18)f]fluorophenylthio)benzylamine (4-[(18)f]-adam, 3) is a potent serotonin transporter (sert) imaging agent. |
2008-06-03 |
2023-08-12 |
Not clear |
| A Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, Stephanie W Watt. Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. American journal of physiology. Heart and circulatory physiology. vol 294. issue 4. 2008-05-29. PMID:18263707. |
the handling of serotonin [5-hydroxytryptamine (5-ht)] depends on the serotonin transporter (sert). |
2008-05-29 |
2023-08-12 |
rat |