| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Markus Storvik, Jari Tiihonen, Tuija Haukijärvi, Erkki Tupal. Amygdala serotonin transporters in alcoholics measured by whole hemisphere autoradiography. Synapse (New York, N.Y.). vol 61. issue 8. 2007-09-12. PMID:17476685. |
the conjuncted alterations in functioning of serotonin transporter (sert) may play a role in the regulation of emotional balance, judgement, and the adverse behavioral effects of ethanol misuse. |
2007-09-12 |
2023-08-12 |
Not clear |
| Chong-Bin Zhu, Jennifer A Steiner, Jaclyn L Munn, Lynette C Daws, William A Hewlett, Randy D Blakel. Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17460150. |
the inactivation of synaptic serotonin (5-hydroxytryptamine, 5-ht) is largely established through the actions of the presynaptic, antidepressant-sensitive 5-ht transporter (sert, slc6a4). |
2007-08-30 |
2023-08-12 |
mouse |
| A V Kalueff, M A Fox, P S Gallagher, D L Murph. Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes, brain, and behavior. vol 6. issue 4. 2007-08-17. PMID:16939636. |
although mice with a targeted disruption of the serotonin transporter (sert) have been studied extensively using various tests, their complex behavioral phenotype is not yet fully understood. |
2007-08-17 |
2023-08-12 |
mouse |
| A V Kalueff, M A Fox, P S Gallagher, D L Murph. Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes, brain, and behavior. vol 6. issue 4. 2007-08-17. PMID:16939636. |
in line with replicated evidence of much enhanced serotonin availability in sert -/- mice, this serotonin syndrome-like state may represent a third factor contributing to their behavioral profile. |
2007-08-17 |
2023-08-12 |
mouse |
| Vishakantha Murthy, Huw M L Davies, Simon J Hedley, Steven R Childer. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical pharmacology. vol 74. issue 2. 2007-08-16. PMID:17540345. |
irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (dat), serotonin (sert) and norepinephrine (net). |
2007-08-16 |
2023-08-12 |
rat |
| Fu-Ming Shen, Jin Wang, Can-Rong Ni, Jian-Guang Yu, Wei-Zhong Wang, Ding-Feng S. Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT(2A) receptors. Clinical and experimental pharmacology & physiology. vol 34. issue 8. 2007-08-16. PMID:17600544. |
using a conjugate of a monoclonal antibody to the serotonin reuptake transporter (sert) and the toxin saporin (anti-sert-sap), which specifically eliminates the neurons that express sert, the effects of ketanserin (0.3 and 3.0 mg/kg, i.g.) |
2007-08-16 |
2023-08-12 |
rat |
| Wei Ni, Stephanie W Watt. 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clinical and experimental pharmacology & physiology. vol 33. issue 7. 2007-08-09. PMID:16789923. |
5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (sert). |
2007-08-09 |
2023-08-12 |
mouse |
| Wei Ni, Stephanie W Watt. 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clinical and experimental pharmacology & physiology. vol 33. issue 7. 2007-08-09. PMID:16789923. |
the function of the serotonin transporter (sert) is to take up and release serotonin (5-hydroxytyptamine (5-ht)) from cells and this function of sert in the central nervous system (cns) is well-documented; sert is the target of selective serotonin reuptake inhibitors used in the treatment of cns disorders, such as depression. |
2007-08-09 |
2023-08-12 |
mouse |
| Wei Ni, Stephanie W Watt. 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clinical and experimental pharmacology & physiology. vol 33. issue 7. 2007-08-09. PMID:16789923. |
the aim of the present review is to discuss our current knowledge of 5-ht and sert in the cardiovascular (cv) system, as well as their function in physiological and pathophysiological states. |
2007-08-09 |
2023-08-12 |
mouse |
| Jeffrey A Deskus, James R Epperson, Charles P Sloan, Joseph A Cipollina, Pierre Dextraze, Jingfang Qian-Cutrone, Qi Gao, Baoqing Ma, Brett R Beno, Gail K Mattson, Thaddeus F Molski, Rudolph G Krause, Matthew T Taber, Nicholas J Lodge, Ronald J Mattso. Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. Bioorganic & medicinal chemistry letters. vol 17. issue 11. 2007-08-07. PMID:17391962. |
a series of indole tetrahydropyridine and indole cyclohexenylamines was prepared, and their binding affinities at the human serotonin transporter (sert) were determined. |
2007-08-07 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
the actions of 5ht are mediated by different types of receptors and terminated by a single 5ht transporter (sert). |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
therefore, sert is a major mechanism that regulates plasma 5ht levels to prevent vasoconstriction and thereby secure a stable blood flow. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
in this study, the response of platelet sert to the plasma 5ht levels was examined within two models: (i) in subjects with chronic hypertension or normotension; (ii) on platelets isolated from normotensive subjects and pretreated with 5ht at various concentrations. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
the platelet 5ht uptake rates were lower during hypertension due to a decrease in vmax with a similar km; also, the decrease in vmax was primarily due to a decrease in the density of sert on the platelet membrane, with no change in whole cell expression. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
furthermore, exogenous 5ht altered the 5ht uptake rates by changing the density of sert molecules on the plasma membrane in a biphasic manner. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
therefore, we hypothesize that in a hypertensive state, the elevated plasma 5ht levels induces a loss in 5ht uptake function in platelets via a decrease in the density of sert molecules on the plasma membrane. |
2007-07-30 |
2023-08-12 |
human |
| B Brenner, J T Harney, B A Ahmed, B C Jeffus, R Unal, J L Mehta, F Kili. Plasma serotonin levels and the platelet serotonin transporter. Journal of neurochemistry. vol 102. issue 1. 2007-07-30. PMID:17506858. |
through the feedback effect of this proposed mechanism, plasma 5ht controls its own concentration levels by modulating the uptake properties of platelet sert. |
2007-07-30 |
2023-08-12 |
human |
| Shunichi Oya, Seok-Rye Choi, Mei-Ping Kung, Hank F Kun. 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand. Nuclear medicine and biology. vol 34. issue 2. 2007-07-20. PMID:17307121. |
two novel ligands with 4' substitution on the phenyl ring b of biphenylthiol, 5-chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine (7) and 2-(2'-((dimethylamino)methyl)-4'-methoxyphenylthio)-5-iodobenzenamine (8), were prepared and tested as potential serotonin transporter (sert) imaging agents. |
2007-07-20 |
2023-08-12 |
rat |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
the 5ht transporter (sert) on the membranes of the placental trophoblast cells controls 5ht levels in the maternal bloodstream to maintain stable transplacental blood flow and simultaneously provide 5ht to the embryo. |
2007-07-12 |
2023-08-12 |
human |
| R Unal, B A Ahmed, B C Jeffus, J T Harney, C S Lyle, Y-K Wu, T C Chambers, E A Reece, F Kili. At diabetes-like concentration, glucose down-regulates the placental serotonin transport system in a cell-cycle-dependent manner. Journal of neurochemistry. vol 101. issue 4. 2007-07-12. PMID:17355243. |
the 5ht uptake rate of placental sert is important for both the mother and the developing embryo. |
2007-07-12 |
2023-08-12 |
human |