| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy Hauck Newman, Joo Hwan Cha, Jianjing Cao, Theresa Kopajtic, Jonathan L Katz, M Laura Parnas, Roxanne Vaughan, John R Leve. Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane. Journal of medicinal chemistry. vol 49. issue 22. 2006-12-05. PMID:17064081. |
moreover, this compound showed moderate binding affinity for the serotonin transporter (sert, k(i) = 109 +/- 14 nm), suggesting the potential utility of [(125)i]11 in both dat and sert protein structure studies. |
2006-12-05 |
2023-08-12 |
Not clear |
| Ralph Buchert, Oliver Schulze, Florian Wilke, Georg Berding, Rainer Thomasius, Kay Petersen, Winfried Brenner, Malte Clause. Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults? Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 1. 2006-12-04. PMID:16391185. |
pet and spect have suggested that there is an age-related decline of up to 10% per decade in the availability of brain serotonin transporter (sert) in healthy subjects, starting as early as the age of 20 y. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
we postulated that modafinil enhances wakefulness by modulating dopamine (dat), norepinephrine (net), or serotonin (sert) transporter activities. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
in vitro, modafinil inhibited [(3)h]dopamine (ic(50) = 6.4 microm), [(3)h]norepinephrine (ic(50) = 35.6 microm), and [(3)h]serotonin (ic(50) > 500 microm) transport via the human dat, net, and sert. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
we postulated that potent dat inhibitors, with low affinity for the serotonin transporter (sert), may elevate endogenously released extracellular dopamine levels to provide therapeutic benefit. |
2006-12-04 |
2023-08-12 |
monkey |
| Mu-Fa Zou, Jianjing Cao, Theresa Kopajtic, Rajeev I Desai, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of medicinal chemistry. vol 49. issue 21. 2006-12-04. PMID:17034144. |
when the (s)-2-carboalkoxy substituent was replaced with (s)-2-ethenyl, the resulting analogue 11 demonstrated the highest dat binding affinity in the series (k(i) = 1.81 nm) with dat selectivity over serotonin transporters (sert; 989-fold), norepinephrine transporters (net; 261-fold) and muscarinic receptors (90-fold). |
2006-12-04 |
2023-08-12 |
human |
| C Lebrand, P Gaspar, D Nicolas, J P Hornun. Transitory uptake of serotonin in the developing sensory pathways of the common marmoset. The Journal of comparative neurology. vol 499. issue 4. 2006-12-01. PMID:17029254. |
immunocytochemical analyses were performed using antisera to 5-ht, to the serotonin transporter (sert), and to the vesicular monoamine transporter (vmat2). |
2006-12-01 |
2023-08-12 |
marmoset |
| C Lebrand, P Gaspar, D Nicolas, J P Hornun. Transitory uptake of serotonin in the developing sensory pathways of the common marmoset. The Journal of comparative neurology. vol 499. issue 4. 2006-12-01. PMID:17029254. |
5-ht, sert, and vmat2 labeled the raphe neurons and their terminal network from embryonic day (e)70 to adulthood. |
2006-12-01 |
2023-08-12 |
marmoset |
| C Lebrand, P Gaspar, D Nicolas, J P Hornun. Transitory uptake of serotonin in the developing sensory pathways of the common marmoset. The Journal of comparative neurology. vol 499. issue 4. 2006-12-01. PMID:17029254. |
accumulation of 5-ht was observed in all the sensory neurons expressing sert and the corresponding axon tracts. |
2006-12-01 |
2023-08-12 |
marmoset |
| David A Gutman, Michael J Owen. Serotonin and norepinephrine transporter binding profile of SSRIs. Essential psychopharmacology. vol 7. issue 1. 2006-11-30. PMID:16989291. |
for the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [sert] or the norepinephrine transporter [net]). |
2006-11-30 |
2023-08-12 |
Not clear |
| Heidi Kaastrup Müller, Ove Wiborg, Jana Haas. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16870614. |
the serotonin transporter (sert) belongs to the slc6 family of sodium- and chloride-dependent neurotransmitter transporters responsible for uptake of amino acids and biogenic amines from extracellular spaces. |
2006-11-27 |
2023-08-12 |
human |
| Heidi Kaastrup Müller, Ove Wiborg, Jana Haas. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16870614. |
co-expression of sert and scamp2 in mammalian cells results in the subcellular redistribution of sert with a decrease in cell surface sert and a concomitant reduction in 5-ht uptake activity. |
2006-11-27 |
2023-08-12 |
human |
| Jae Seung Kim, Masanori Ichise, Janet Sangare, Robert B Inni. PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 2. 2006-11-24. PMID:16455625. |
parametric imaging of serotonin transporters (sert) with 11c-labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)benzonitrile ([11c]dasb) pet is a useful data analysis tool. |
2006-11-24 |
2023-08-12 |
human |
| Karley Y Little, Lian Zhang, Edwin Coo. Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects. Journal of psychiatry & neuroscience : JPN. vol 31. issue 5. 2006-11-09. PMID:16951736. |
long-term antidepressant drug exposure may regulate its target molecule - the serotonin transporter (sert). |
2006-11-09 |
2023-08-12 |
human |
| Karley Y Little, Lian Zhang, Edwin Coo. Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects. Journal of psychiatry & neuroscience : JPN. vol 31. issue 5. 2006-11-09. PMID:16951736. |
this effect could be related to an individual's genotype for an sert promoter polymorphism (human serotonin transporter coding [5-httlpr]). |
2006-11-09 |
2023-08-12 |
human |
| Aina Westrheim Ravn. Three-dimensional models of neurotransmitter transporters and their interactions with cocaine and S-citalopram. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 7. issue 2. 2006-11-08. PMID:16684682. |
then three-dimensional models of the neurotransmitter transporters hdat, hsert and hnet were constructed based on the nhaa model and studies of ligand binding to mutated dopamine transporter (dat) and serotonin transporter (sert). |
2006-11-08 |
2023-08-12 |
human |
| Ana Marin D Carneiro, Randy D Blakel. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. The Journal of biological chemistry. vol 281. issue 34. 2006-11-06. PMID:16803896. |
emerging data indicate the existence of multiple regulatory processes supporting serotonin (5ht) transporter (sert) capacity including regulated trafficking and catalytic activation, influenced by post-translational modifications and transporter-associated proteins. |
2006-11-06 |
2023-08-12 |
Not clear |
| Guangrong Zheng, David B Horton, Agripina G Deaciuc, Linda P Dwoskin, Peter A Crook. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorganic & medicinal chemistry letters. vol 16. issue 19. 2006-11-02. PMID:16905316. |
a series of des-keto lobeline analogs has been synthesized and evaluated for their ability to inhibit the dopamine transporter (dat) and serotonin transporter (sert) function and for their affinity for the synaptic vesicle monoamine transporter (vmat2), as well as for alpha4beta2( *) and alpha7( *) neuronal nicotinic acetylcholine receptors (nachrs). |
2006-11-02 |
2023-08-12 |
Not clear |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
treatments with high dose psychostimulants that block dat as well as the norepinephrine (net) and serotonin (sert) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired ppi in wild-type mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Chong-Bin Zhu, Randy D Blakely, William A Hewlet. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16452991. |
we have demonstrated that activation of p38 mitogen-activated protein kinase (mapk) induces a catalytic activation of the serotonin transporter (sert) arising from a reduction in the sert km for 5-hydroxytryptamine (5-ht). |
2006-11-01 |
2023-08-12 |
mouse |