| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Bauman. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515341. |
these changes have been viewed as evidence for 5-ht neurotoxicity, but no studies have measured sert protein levels. |
2004-01-06 |
2023-08-12 |
rat |
| Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Bauman. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515341. |
despite the large decreases in sert binding and depletion of tissue 5-ht that occurred with d-fen administration, sert protein expression, as determined by western blot analysis, did not change in either tissue or time point. |
2004-01-06 |
2023-08-12 |
rat |
| Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Bauman. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). vol 50. issue 3. 2004-01-06. PMID:14515341. |
these results support the hypothesis that decreases in tissue 5-ht and sert binding sites induced by d-fen and pca reflect neuroadaptive changes, rather than neurotoxic effects. |
2004-01-06 |
2023-08-12 |
rat |
| Kristine Krajnak, Katherine L Rosewell, Marilyn J Duncan, Phyllis M Wis. Aging, estradiol and time of day differentially affect serotonin transporter binding in the central nervous system of female rats. Brain research. vol 990. issue 1-2. 2004-01-06. PMID:14568333. |
estrogen-related changes in serotonergic neuronal transmission, including changes in the number of serotonin transporter (sert) binding sites, have been cited as a possible cause for changes in mood, memory and sleep that occur during the menopausal transition. |
2004-01-06 |
2023-08-12 |
rat |
| Deniz Ozaslan, Sophie Wang, Billow A Ahmed, Arif M Kocabas, John C McCastlain, Anca Bene, Fusun Kili. Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues. The Journal of biological chemistry. vol 278. issue 45. 2004-01-05. PMID:12944413. |
the serotonin transporter (sert) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules. |
2004-01-05 |
2023-08-12 |
Not clear |
| Deniz Ozaslan, Sophie Wang, Billow A Ahmed, Arif M Kocabas, John C McCastlain, Anca Bene, Fusun Kili. Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues. The Journal of biological chemistry. vol 278. issue 45. 2004-01-05. PMID:12944413. |
a physical interaction between myosin and sert was apparent; however, defects in sialylated n-glycans impaired association of sert with myosin as well as the stimulation of the serotonin uptake function in the cgmp-dependent pathway. |
2004-01-05 |
2023-08-12 |
Not clear |
| Alena Lira, Mingming Zhou, Nathalie Castanon, Mark S Ansorge, Joshua A Gordon, Jasmine H Francis, Maria Bradley-Moore, Josko Lira, Mark D Underwood, Victoria Arango, Hank F Kung, Myron A Hofer, René Hen, Jay A Gingric. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biological psychiatry. vol 54. issue 10. 2003-12-29. PMID:14625138. |
as a key regulator of serotonergic activity and target of many antidepressant treatments, the serotonin transporter (sert) represents a potential mediator of anxiety- and depression-related behaviors. |
2003-12-29 |
2023-08-12 |
mouse |
| Christian A Heidbreder, Massimiliano Bianchi, Laurent P Lacroix, Stefania Faedo, Elisabetta Perdona, Rosaria Remelli, Paolo Cavanni, Francesco Cresp. Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. Synapse (New York, N.Y.). vol 50. issue 4. 2003-12-19. PMID:14556231. |
accordingly, we first examined the potency of mpep to bind to or inhibit uptake at the net as well as the dopamine and serotonin transporters (dat and sert, respectively). |
2003-12-19 |
2023-08-12 |
human |
| I Armando, O A Tjurmina, Q Li, D L Murphy, J M Saavedr. The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression. Neuroendocrinology. vol 78. issue 4. 2003-12-16. PMID:14583654. |
high numbers of serotonin transporter (sert) binding sites and high serotonin (5-ht) content are expressed in the adrenal medulla of wild-type (sert+/+) mice. |
2003-12-16 |
2023-08-12 |
mouse |
| I Armando, O A Tjurmina, Q Li, D L Murphy, J M Saavedr. The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression. Neuroendocrinology. vol 78. issue 4. 2003-12-16. PMID:14583654. |
in littermate sert-/- mice, which do not express sert binding sites, the basal adrenomedullary 5-ht content is significantly reduced and does not increase after stress. |
2003-12-16 |
2023-08-12 |
mouse |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 9. 2003-12-12. PMID:12670645. |
we have designed and synthesized a dual inhibitor of acetylcholinesterase (ache) and serotonin transporter (sert) as a novel class of treatment drugs for alzheimer's disease on the basis of a hypothetical model of the ache active site. |
2003-12-12 |
2023-08-12 |
mouse |
| Kimberly L Simpson, Barry D Waterhouse, Rick C S Li. Differential expression of nitric oxide in serotonergic projection neurons: neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets. The Journal of comparative neurology. vol 466. issue 4. 2003-12-11. PMID:14566945. |
rats were injected with retrograde tracer into vibrissae-related target areas or with anterograde tracer into dr. nadph-diaphorase (nadphd) histochemistry or nos-immunostaining was combined with serotonin (5ht)- or serotonin transporter (sert)-immunolabeling to examine: 1) the presence of no in 5ht-containing axons from dr; 2) the distribution of no-containing fibers with respect to other nitrergic profiles in the somatosensory system; and 3) the propensity for individual projection neurons in specific subdivisions of dr to colocalize 5ht and no. |
2003-12-11 |
2023-08-12 |
rat |
| Boris Mlinar, Renato Corradett. Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511335. |
block of the serotonin transporter (sert) with citalopram slowed the time course and reduced overall 5-ht release by mdma. |
2003-12-05 |
2023-08-12 |
rat |
| Boris Mlinar, Renato Corradett. Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. The European journal of neuroscience. vol 18. issue 6. 2003-12-05. PMID:14511335. |
thus although the sert reversal contributes, a direct vesicle-depleting action is essential for mdma release of 5-ht. |
2003-12-05 |
2023-08-12 |
rat |
| F Martel, E Keatin. Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. Placenta. vol 24. issue 4. 2003-11-20. PMID:12657510. |
as jar cells, as well as the placenta, express the neuronal serotonin transporter (sert), a comparison between the uptake of (3)h-mpp(+) and (3)h-serotonin ((3)h-5ht) was made. |
2003-11-20 |
2023-08-12 |
human |
| L Keith Henry, Erika M Adkins, Qiao Han, Randy D Blakel. Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. The Journal of biological chemistry. vol 278. issue 39. 2003-11-17. PMID:12869570. |
aminoethylmethanethiosulfonate (mtsea), [2-(trimethylammonium) ethyl]methanethiosulfonate bromide (mtset), and sodium (2-sulfonatoethyl)-methanethiosulfonate (mtses) similarly and profoundly inactivated 5-ht transport by sert mutants d98c, g100c, w103c, and y107c. |
2003-11-17 |
2023-08-12 |
human |
| Toshiya Murai, Henryk Barthel, Jörg Berrouschot, Dietlind Sorger, D Yves von Cramon, Ulrich Mülle. Neuroimaging of serotonin transporters in post-stroke pathological crying. Psychiatry research. vol 123. issue 3. 2003-11-12. PMID:12928109. |
to elucidate the role of serotonin neurotransmission for pc, a pilot study was performed using single photon emission computed tomography with [123i]beta-cit to estimate central (midbrain/pons and thalamus/hypothalamus) serotonin transporter (sert) densities in 15 stroke patients who did or did not have pc. |
2003-11-12 |
2023-08-12 |
Not clear |
| N Z Lu, A J Eshleman, A Janowsky, C L Bethe. Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660809. |
ovarian steroid regulation of serotonin reuptake transporter (sert) binding, distribution, and function in female macaques. |
2003-11-04 |
2023-08-12 |
Not clear |
| N Z Lu, A J Eshleman, A Janowsky, C L Bethe. Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660809. |
the serotonin reuptake transporter (sert) plays an important role in serotonin neurotransmission and in several psychopathological disorders such as depression and anxiety disorders. |
2003-11-04 |
2023-08-12 |
Not clear |
| N Z Lu, A J Eshleman, A Janowsky, C L Bethe. Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques. Molecular psychiatry. vol 8. issue 3. 2003-11-04. PMID:12660809. |
in this study, we investigated whether the ovarian steroids, estrogen (e) and progesterone (p) regulate sert binding, intracellular distribution, and function using [(3)h]citalopram ligand binding with quantitative autoradiography, immunofluorescence histochemistry with confocal microscopy and [(3)h]serotonin uptake, respectively. |
2003-11-04 |
2023-08-12 |
Not clear |