| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Sebastiani, Allyson Sabatelli, M Danielle McDonal. Mild hypoxia exposure impacts peripheral serotonin uptake and degradation in Gulf toadfish, Opsanus beta. The Journal of experimental biology. 2022-06-06. PMID:35662341. |
previous studies have shown that inhibiting sert, which would inhibit 5-ht uptake and degradation, attenuates parts of the cardiovascular hypoxia reflex in gulf toadfish (opsanus beta), suggesting that these 5-ht clearance processes may be important during hypoxia exposure. |
2022-06-06 |
2023-08-14 |
Not clear |
| Daniela Krause, Agnieszka Chrobok, Susanne Karch, Daniel Keeser, Kirsi M Manz, Walter Koch, Matthias Brendel, Axel Rominger, Gabi Koller, Nina Behle, Oliver Pogarel. Binding potential changes of SERT in patients with depression are associated with remission: A prospective [¹²³I]β-CIT-SPECT study. Experimental and clinical psychopharmacology. 2022-05-23. PMID:35604719. |
addressing this challenge, we investigated functional correlates of remission by assessment of serotonin and dopamine transporter availability (sert and dat) using single-photon emission computed tomography (spect). |
2022-05-23 |
2023-08-13 |
human |
| Jesús E Yepez, Jorge Juáre. Modafinil acquires reinforcing effects when combined with citalopram. Pharmacology, biochemistry, and behavior. 2022-05-23. PMID:35605783. |
its action mechanism consists in inhibiting dopamine (dat) and norepinephrine (net) transporters, but it has no affinity for the serotonin transporter (sert). |
2022-05-23 |
2023-08-13 |
rat |
| Molly H B Amador, M Danielle McDonal. Is serotonin uptake by peripheral tissues sensitive to hypoxia exposure? Fish physiology and biochemistry. 2022-05-18. PMID:35583623. |
in the gulf toadfish (opsanus beta), the serotonin (5-ht) transporter (sert) is highly expressed in the heart, and the heart and gill both demonstrate the capacity for sert-mediated uptake of 5-ht from the circulation. |
2022-05-18 |
2023-08-13 |
Not clear |
| Ángel A Islas, Thomas Scio. Allosteric Binding of MDMA to the Human Serotonin Transporter (hSERT) via Ensemble Binding Space Analysis with ΔG Calculations, Induced Fit Docking and Monte Carlo Simulations. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566327. |
mdma enhances monoaminergic neurotransmission in the brain and its valuable psychoactive effects are associated to a dual action on the 5-ht transporter (sert). |
2022-05-14 |
2023-08-13 |
human |
| Ángel A Islas, Thomas Scio. Allosteric Binding of MDMA to the Human Serotonin Transporter (hSERT) via Ensemble Binding Space Analysis with ΔG Calculations, Induced Fit Docking and Monte Carlo Simulations. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566327. |
this drug inhibits the reuptake of 5-ht (serotonin) and reverses its flow, acting as a substrate for the sert, which possesses a central binding site (s1) for antidepressants as well as an allosteric (s2) one. |
2022-05-14 |
2023-08-13 |
human |
| Dino Luethi, Gerhard J Schütz, Harald H Sitt. Single Molecule Analysis Reveals Dimer Formation of the Norepinephrine Transporter at the Plasma Membrane of Live Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552962. |
using single molecule microscopy, we previously reported that the serotonin transporter (sert) co-exists as monomers, dimers, and higher-order oligomers, while the dopamine transporter (dat) forms monomers and dimers only. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kevin P Currie, Mary Beth Bauer, Rebecca L Brindle. The Serotonin Transporter Modulates the Kinetics and Quantal Size of Vesicular Fusion Events in Sympathoadrenal Chromaffin Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553323. |
the antidepressant-sensitive serotonin transporter (sert) is a key regulator of serotonin (5-ht) signaling and availability in the cns. |
2022-05-13 |
2023-08-13 |
Not clear |
| Nikhil M Urs, Sharonda Harris, Sara M Green, Mayank M Kuma. A Role for Cortical Dopamine in the Paradoxical Calming Effects of Psychostimulants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554609. |
however, serotonin (5-ht) transporter (sert) inhibitor fluoxetine elevates only serotonin in all three genotypes. |
2022-05-13 |
2023-08-13 |
mouse |
| Nikki J Clauss, W A Owens, Melissa Vitela, Melodi A Bowman, Felix P Mayer, Diethart Schmid, Marion Holy, Harrold H Sitte, Geogianna G Gould, Wouter Koek, Lynette C Daw. Ethanol Inhibits Dopamine Uptake and Augments Rewarding Effects of Cocaine via Organic Cation Transporter 3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554677. |
both cocaine (blocker of dopamine (da), norepinephrine and serotonin transporters, dat, net and sert, respectively) and ethanol (etoh) increase extracellular levels of these monoamines. |
2022-05-13 |
2023-08-13 |
Not clear |
| Amy Fassler, Davis Rens, Ruhi Shah, Kennan Chojnacki, Kai Ren. Understanding of the Serotonin Transporter Mechanism-Targeting Drug Therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555773. |
the serotonin transporter (sert) is a protein located within the presynaptic membrane and is activated by 5-hydroxytryptamine (5-ht), a chemical messenger that releases serotonin. |
2022-05-13 |
2023-08-13 |
Not clear |
| Amy Fassler, Davis Rens, Ruhi Shah, Kennan Chojnacki, Kai Ren. Understanding of the Serotonin Transporter Mechanism-Targeting Drug Therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555773. |
the sert protein re-uptakes 5-ht during its release, leading to the regulation of the neurotransmitter's concentration in the synaptic cleft. |
2022-05-13 |
2023-08-13 |
Not clear |
| Amy Fassler, Davis Rens, Ruhi Shah, Kennan Chojnacki, Kai Ren. Understanding of the Serotonin Transporter Mechanism-Targeting Drug Therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555773. |
over-activation of sert leads to less 5-ht, in turn lowering serotonin concentration, resulting in a higher chance of developing depression. |
2022-05-13 |
2023-08-13 |
Not clear |
| Susan M Greene, Blanka Bordas, Gloria-Andrea Alcala, Yatzil R Sanchez, Mithil K Penta, Lauren E Honan, Jorge A Gomez, Brett C Ginsburg, Lynette C Daws, Georgianna G Goul. Expression of Key Modulators of Serotonergic Neurotransmission after Chronic Metformin Treatment. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555936. |
since btbr social behavior is enhanced by selective serotonin reuptake inhibitors (ssris) such as sertraline, and their chronic use reduces or otherwise alters receptor and transporter expression in the brain, we hypothesized that with chronic metformin treatment, expression of key regulators of serotonin neurotransmission such as the serotonin transporter (sert) or organic cation transporters (octs) responsible for serotonin clearance would be reduced. |
2022-05-13 |
2023-08-13 |
Not clear |
| Suzanne Underhill, Susan Amar. 3,4-methylenedioxymethamphetamine (MDMA) stimulates activation of TAAR1 and subsequent neurotransmitter transporter internalization in serotonin neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556756. |
in this study, we show that mdma enters serotonin neurons through the 5-ht transporter (sert) and activates a similar signaling cascade. |
2022-05-13 |
2023-08-13 |
mouse |
| Shane Comiskey, Aisha Qazi, Abhijith Eathara, Anchal Sharma, Nathan Calzadilla, Seema Saksena, Pradeep K Dudeja, Waddah Alrefai, Ravinder K Gil. Dietary Indole-3-Carbinol Supplementation Restores Epithelial Abnormalities in SAMP1/YitFc Mouse Model of Ileitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557290. |
a decrease in fibroblast growth factor 15 (fgf15) and the epithelial ion transporters serotonin transporter (sert) and organic solute transporter (ost) were observed in ileal mucosa of samp mice vs. akr, and the supplementation of i3c mitigated these decreases by 30-58% (p<.01). |
2022-05-13 |
2023-08-13 |
mouse |
| Georgianna G Gould, Livia F Ferreira, Nikhita Pathapati, Mary C Nunn, Susan M Greene, Brett C Ginsburg, Stephen T Schult. Acute Low Dose Cannabidiol Treatment Boosts Social Interaction Preference in Male Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560572. |
next, acute 10 mg/kg cbd was compared to vehicle treatment in serotonin transporter (sert) knockout mice, as sert deficiency is an autism risk factor, and in c57bl6/j mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Smriti Patodia, Alyma Somani, Joan Liu, Alice Cattaneo, Beatrice Paradiso, Maria Garcia, Muhammad Othman, Beate Diehl, Orrin Devinsky, James D Mills, Jackie Foong, Maria Tho. Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP. Brain pathology (Zurich, Switzerland). 2022-04-28. PMID:35478467. |
the immunohistochemistry labelling index (li) and axonal length (al) of serotonin transporter (sert)-positive axons were quantified in 13 regions of interest with image analysis. |
2022-04-28 |
2023-08-13 |
Not clear |
| Simona Pergolizzi, Alessio Alesci, Antonio Centofanti, Marialuisa Aragona, Socrate Pallio, Ludovico Magaudda, Giuseppina Cutroneo, Eugenia Rita Laurian. Role of Serotonin in the Maintenance of Inflammatory State in Crohn's Disease. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453516. |
these actions are mediated by a large family of serotonin receptors and specialized serotonin transporter (sert) located on a variety of cell types in the gut. |
2022-04-23 |
2023-08-13 |
Not clear |
| Diana Marie Battaglia, Maria D Sanchez-Pino, Charles D Nichols, Timothy P Foste. Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease. Frontiers in microbiology. vol 13. 2022-04-08. PMID:35391733. |
hsv infection induced expression of the critical serotonin synthesis enzymes tph-1, tph-2, and dopa decarboxylase (ddc), as well as the serotonin transporter, sert. |
2022-04-08 |
2023-08-13 |
Not clear |