| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Marie Battaglia, Maria D Sanchez-Pino, Charles D Nichols, Timothy P Foste. Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease. Frontiers in microbiology. vol 13. 2022-04-08. PMID:35391733. |
exogenous addition of serotonin increased hsv-1 yield, while both tph-1/2 and sert pharmacological inhibition reduced viral yield. |
2022-04-08 |
2023-08-13 |
Not clear |
| QiQi Zhou, George Nicholas Vern. Disruption of the Mucosal Serotonin Reuptake Transporter (SERT) through Gut Dysbiosis. Gastroenterology. 2022-03-28. PMID:35341788. |
disruption of the mucosal serotonin reuptake transporter (sert) through gut dysbiosis. |
2022-03-28 |
2023-08-13 |
Not clear |
| Yangfeng Xu, Mitchel Kappen, Kathelijne Peremans, Dimitri De Bundel, Ann Van Eeckhaut, Nick Van Laeken, Filip De Vos, Andre Dobbeleir, Jimmy H Saunders, Chris Baeke. Accelerated HF-rTMS Modifies SERT Availability in the Subgenual Anterior Cingulate Cortex: A Canine [ Journal of clinical medicine. vol 11. issue 6. 2022-03-25. PMID:35329857. |
this sham-controlled study aimed to evaluate the effects of accelerated high frequency rtms (ahf-rtms) over the left frontal cortex on the serotonin transporter (sert) in healthy beagle dogs. |
2022-03-25 |
2023-08-13 |
Not clear |
| Ieva Poceviciute, Rokas Buisas, Osvaldas Ruksenas, Valentina Vengelien. Melatonin Reduces Alcohol Drinking in Rats with Disrupted Function of the Serotonergic System. Journal of personalized medicine. vol 12. issue 3. 2022-03-25. PMID:35330355. |
to achieve this goal, we treated rats neonatally with the selective serotonin transporter (sert) inhibitor escitalopram. |
2022-03-25 |
2023-08-13 |
rat |
| Nadeem, Shumaila Usman, Rehan Imad, Uzair Nisar, Irfan Khan, Ghulam Abba. Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats. Metabolic brain disease. 2022-03-18. PMID:35303245. |
additionally, the brain tryptophan, 5-ht (5-hydroxytryptamine) and its metabolite 5-hiaa (5-hydroxyindoleacetic acid) levels were quantified using enzyme linked immunosorbent assay (elisa), while expression of sert (serotonin receptor), 5-ht |
2022-03-18 |
2023-08-13 |
rat |
| Hongsong Feng, Kaifu Gao, Dong Chen, Li Shen, Alfred J Robison, Edmund Ellsworth, Guo-Wei We. Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks. Journal of chemical theory and computation. 2022-03-16. PMID:35294204. |
among them, the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters are three major targets. |
2022-03-16 |
2023-08-13 |
Not clear |
| Tamires Gregorio, Flaviano Lorenzon, Fernanda Niebisch, Rafaela Carla Kachel Stolte, Alex Rafacho, Gustavo Jorge Dos Santos, Cilene Lino de Oliveira, Fernanda Barbosa Lim. Antidepressant-like activity of gestational administration of vitamin D is suppressed by prenatal overexposure to dexamethasone in female Wistar rats. Physiology & behavior. vol 249. 2022-03-15. PMID:35227701. |
prenatal dexamethasone reduced the protein content of sert, tph, and 5-ht |
2022-03-15 |
2023-08-16 |
rat |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
despite their therapeutic potential, surprisingly little is known about the endocytosis of the serotonin receptors (5-ht receptors) or the serotonin transporter (sert). |
2022-03-14 |
2023-08-13 |
Not clear |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
sert internalizes serotonin from the extracellular space into the cell to limit the availability of serotonin for receptor binding and signaling. |
2022-03-14 |
2023-08-13 |
Not clear |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
endocytosis of sert reduces serotonin uptake, facilitating serotonin signaling. |
2022-03-14 |
2023-08-13 |
Not clear |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
ssris predominantly inhibit sert, preventing serotonin uptake to enhance 5-ht receptor signaling, while hallucinogenic compounds directly activate specific 5-ht receptors, altering their interaction with endocytic adaptor proteins to induce alternate signaling outcomes. |
2022-03-14 |
2023-08-13 |
Not clear |
| Nikita Deo, Gregory Redpat. Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety. Frontiers in cellular neuroscience. vol 15. 2022-03-14. PMID:35280519. |
in this review, we detail the endocytic regulation of 5-ht receptors and sert and outline how ssris and hallucinogenic compounds modulate serotonin signaling through endocytosis. |
2022-03-14 |
2023-08-13 |
Not clear |
| Takuya Nagashima, Takashi Hayakawa, Hayato Akimoto, Kimino Minagawa, Yasuo Takahashi, Satoshi Asa. Identifying antidepressants less likely to cause hyponatremia: triangulation of retrospective cohort, disproportionality, and pharmacodynamic studies. Clinical pharmacology and therapeutics. 2022-03-08. PMID:35258103. |
finally, pharmacoepidemiological-pharmacodynamic analysis revealed a significant correlation between the decrease in serum sodium levels and binding affinity for serotonin transporter (sert; r=-0.84, p=0.02), suggesting that lower binding affinity of mirtazapine, fluvoxamine, and milnacipran against sert is responsible for the above difference. |
2022-03-08 |
2023-08-13 |
Not clear |
| Matthew C Chan, Erik Procko, Diwakar Shukl. Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation. ACS chemical neuroscience. 2022-03-08. PMID:35258286. |
the reuptake of the neurotransmitter serotonin from the synaptic cleft by the serotonin transporter, sert, is essential for proper neurological signaling. |
2022-03-08 |
2023-08-13 |
Not clear |
| Matthew C Chan, Erik Procko, Diwakar Shukl. Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation. ACS chemical neuroscience. 2022-03-08. PMID:35258286. |
biochemical studies have shown that thr276 of transmembrane helix 5 is a site of pkg-mediated sert phosphorylation, which has been proposed to shift the sert conformational equilibria to promote inward-facing states, thus enhancing 5-ht transport. |
2022-03-08 |
2023-08-13 |
Not clear |
| Matthew C Chan, Erik Procko, Diwakar Shukl. Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation. ACS chemical neuroscience. 2022-03-08. PMID:35258286. |
this in turn decreases the free energy barriers for sert to transition to the inward-facing state, thus facilitating 5-ht import. |
2022-03-08 |
2023-08-13 |
Not clear |
| Sharonda S Harris, Sara M Green, Mayank Kumar, Nikhil M Ur. A role for cortical dopamine in the paradoxical calming effects of psychostimulants. Scientific reports. vol 12. issue 1. 2022-02-25. PMID:35210489. |
however, the 5-ht transporter (sert) inhibitor fluoxetine elevates only 5-ht in all three genotypes. |
2022-02-25 |
2023-08-13 |
mouse |
| Kazuki Nagayas. Serotonin transporter: Recent progress of in silico ligand prediction methods and structural biology towards structure-guided in silico design of therapeutic agents. Journal of pharmacological sciences. vol 148. issue 3. 2022-02-18. PMID:35177208. |
serotonin transporter (sert) is a membrane transporter which terminates neurotransmission of serotonin through its reuptake. |
2022-02-18 |
2023-08-13 |
human |
| Jun Gao, Tingting Xiong, Gintautas Grabauskas, Chung Owyan. Mucosal serotonin reuptake transporter (SERT) expression in IBS is modulated by gut microbiota via mast cell-prostaglandin E2. Gastroenterology. 2022-02-15. PMID:35167867. |
mucosal serotonin reuptake transporter (sert) expression in ibs is modulated by gut microbiota via mast cell-prostaglandin e2. |
2022-02-15 |
2023-08-13 |
Not clear |
| Jun Gao, Tingting Xiong, Gintautas Grabauskas, Chung Owyan. Mucosal serotonin reuptake transporter (SERT) expression in IBS is modulated by gut microbiota via mast cell-prostaglandin E2. Gastroenterology. 2022-02-15. PMID:35167867. |
increased colonic serotonin (5-ht) level and decreased serotonin reuptake transporter (sert) expression in irritable bowel syndrome (ibs) may contribute to diarrhea and visceral hypersensitivity. |
2022-02-15 |
2023-08-13 |
Not clear |