| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew C Chan, Balaji Selvam, Heather J Young, Erik Procko, Diwakar Shukl. The Substrate Import Mechanism of the Human Serotonin Transporter. Biophysical journal. 2022-02-03. PMID:35114149. |
the serotonin transporter, sert, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. |
2022-02-03 |
2023-08-13 |
human |
| Matthew C Chan, Balaji Selvam, Heather J Young, Erik Procko, Diwakar Shukl. The Substrate Import Mechanism of the Human Serotonin Transporter. Biophysical journal. 2022-02-03. PMID:35114149. |
the cryo-em structures of sert bound to ibogaine and the physiological substrate serotonin resolved in different states provided a glimpse of functional conformations at atomistic resolution. |
2022-02-03 |
2023-08-13 |
human |
| Roberto Chiocchetti, Giorgia Galiazzo, Fiorella Giancola, Claudio Tagliavia, Chiara Bernardini, Monica Forni, Marco Pietr. Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines. Frontiers in veterinary science. vol 8. 2022-01-24. PMID:35071391. |
the serotonin transporter (sert), responsible for serotonin reuptake and signaling termination, plays a prominent role in gastrointestinal physiology, representing a promising therapeutic target in digestive disorders. |
2022-01-24 |
2023-08-13 |
human |
| Bryony N Thorne, Bart A Ellenbroek, Darren J Da. Sex bias in the serotonin transporter knockout model: implications for neuropsychiatric disorder research. Neuroscience and biobehavioral reviews. 2022-01-23. PMID:35066017. |
the serotonin reuptake transporter (sert) is an important regulator of synaptic serotonin, being an important pharmacological target with genetic variants implicated with risk of developing nsd. |
2022-01-23 |
2023-08-13 |
human |
| Bingqian Zhou, Ge Jin, Xiaoqi Pang, Qi Mo, Jie Bao, Tiaotiao Liu, Jingyi Wu, Runxiang Xie, Xiang Liu, Jinghua Liu, Hongwei Yang, Xin Xu, Bangmao Wang, Hailong Ca. Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood. Pharmacological research. 2022-01-22. PMID:35065201. |
mechanically, lgg colonization activated epithelial growth factor receptor (egfr) and enhanced serotonin transporter (sert) expression and modulated serotonergic system in the intestine, and increased brain-derived neurotrophic factor and γ-aminobutyric acid receptor levels in the hippocampus and amygdala. |
2022-01-22 |
2023-08-13 |
mouse |
| Bryony N Thorne, Bart A Ellenbroek, Darren J Da. The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner. Journal of neuroscience research. 2022-01-19. PMID:35043462. |
the serotonin transporter (sert) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti-depressant drug. |
2022-01-19 |
2023-08-13 |
human |
| Bryony N Thorne, Bart A Ellenbroek, Darren J Da. The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner. Journal of neuroscience research. 2022-01-19. PMID:35043462. |
human allelic variants of the serotonin transporter-linked polymorphic region (5-httlpr) such as the s/s variant, are associated with reduced sert expression and increased susceptibility for developing neuropsychiatric disorders. |
2022-01-19 |
2023-08-13 |
human |
| Hanyi Fang, Samantha Rossano, Xingxing Wang, Nabeel Nabulsi, Brian Kelley, Krista Fowles, Jim Ropchan, Stephen M Strittmatter, Richard E Carson, Yiyun Huan. Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [ Molecular imaging and biology. 2022-01-12. PMID:35020138. |
the presynaptic serotonin transporter (sert) is a marker of 5-ht innervation. |
2022-01-12 |
2023-08-13 |
Not clear |
| Judit Cabana-Domínguez, Bàrbara Torrico, Andreas Reif, Noèlia Fernàndez-Castillo, Bru Corman. Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders. Translational psychiatry. vol 12. issue 1. 2022-01-11. PMID:35013130. |
to do so, we elaborated four different gene sets: two 'wide' selections for dopamine (da) and for serotonin (sert) using the gene ontology and kegg pathways tools, and two'core' selections for the same systems, manually curated. |
2022-01-11 |
2023-08-13 |
Not clear |
| Kyoungjune Pak, Keunyoung Kim, Seongho Seo, Myung Jun Lee, In Joo Ki. Serotonin transporter is negatively associated with body mass index after glucose loading in humans. Brain imaging and behavior. 2022-01-04. PMID:34981428. |
serotonin transporter (sert) is a presynaptically localized membrane protein that regulates the serotonin transmission via its reuptake of released serotonin. |
2022-01-04 |
2023-08-13 |
Not clear |
| Fahad Aldosary, Sandhaya Norris, Philippe Tremblay, Jonathan S James, James C Ritchie, Pierre Blie. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The international journal of neuropsychopharmacology. 2021-12-27. PMID:34958348. |
atomoxetine is a net inhibitor but also has some affinity for the serotonin reuptake transporter (sert). |
2021-12-27 |
2023-08-13 |
Not clear |
| Andrea S Grunst, Melissa L Grunst, Nicky Staes, Bert Thys, Rianne Pinxten, Marcel Een. Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits. Scientific reports. vol 11. issue 1. 2021-12-21. PMID:34930949. |
serotonin transporter (sert) polymorphisms, personality and problem-solving in urban great tits. |
2021-12-21 |
2023-08-13 |
Not clear |
| Andrea S Grunst, Melissa L Grunst, Nicky Staes, Bert Thys, Rianne Pinxten, Marcel Een. Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits. Scientific reports. vol 11. issue 1. 2021-12-21. PMID:34930949. |
genes in the serotonergic signaling pathway, including the serotonin transporter gene (sert), are candidates for affecting animal personality, cognition and fitness. |
2021-12-21 |
2023-08-13 |
Not clear |
| Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Saka. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. Journal of pharmacological sciences. vol 148. issue 1. 2021-12-20. PMID:34924125. |
herein, we investigated the role of flurbiprofen in regulating serotonin transporter (sert) function via membrane trafficking. |
2021-12-20 |
2023-08-13 |
Not clear |
| Jiude Mao, Jessica A Kinkade, Nathan J Bivens, R Michael Roberts, Cheryl S Rosenfel. Placental Changes in the serotonin transporter (Slc6a4) knockout mouse suggest a role for serotonin in controlling nutrient acquisition. Placenta. vol 115. 2021-12-10. PMID:34649169. |
the high affinity 5-ht transporter slc6a4 (also known as sert) is the target of such drugs and likely controls much of 5-ht uptake into ptgc and other placental cells. |
2021-12-10 |
2023-08-13 |
mouse |
| Tatiana de Queiroz Oliveira, Adriano José Maia Chaves Filho, Paloma Marinho Jucá, Michelle Verde Ramos Soares, Natássia Lopes Cunha, Charliene Freire Xavier Vieira, Carlos Venício Jataí Gadelha Filho, Glautemberg de Almeida Viana, Gabriela Mariângela Farias De Oliveira, Danielle Silveira Macedo, Silvânia Maria Mendes Vasconcelo. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. Behavioural brain research. vol 419. 2021-12-10. PMID:34798169. |
also, hippocampus (hc) protein expression of the serotonin transporter (sert), synaptophysin, protein kinase b-akt (total and phosphorylated) and the cytokines il-4 and il-6 were investigated. |
2021-12-10 |
2023-08-13 |
mouse |
| Thomas J F Angenoorth, Stevan Stankovic, Marco Niello, Marion Holy, Simon D Brandt, Harald H Sitte, Julian Maie. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884800. |
many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (slc6) monoamine transporters for norepinephrine (net; norepinephrine transporter), dopamine (dat; dopamine transporter) and serotonin (sert; serotonin transporter). |
2021-12-10 |
2023-08-13 |
human |
| Ian D Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G Bellocchio, Travis Josephs, Sandra J Rosentha. A Novel Biotinylated Homotryptamine Derivative for Quantum Dot Imaging of Serotonin Transporter in Live Cells. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867196. |
the serotonin transporter (sert) is the primary target for selective serotonin reuptake inhibitor (ssri) antidepressants that are thought to exert their therapeutic effects by increasing the synaptic concentration of serotonin. |
2021-12-07 |
2023-08-13 |
Not clear |
| Ian D Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G Bellocchio, Travis Josephs, Sandra J Rosentha. A Novel Biotinylated Homotryptamine Derivative for Quantum Dot Imaging of Serotonin Transporter in Live Cells. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867196. |
we demonstrated that idt785 enabled quantum dot (qd) labeling of membrane sert in transfected hek-293 cultures that could be blocked using the high affinity serotonin reuptake inhibitor paroxetine. |
2021-12-07 |
2023-08-13 |
Not clear |
| Catharine Montgomery, Carl A Robert. Neurological and cognitive alterations induced by MDMA in humans. Experimental neurology. vol 347. 2021-12-03. PMID:34624331. |
mdma produces its acute subjective effects primarily by stimulating the release of serotonin via action at the serotonin transporter (sert). |
2021-12-03 |
2023-08-13 |
Not clear |