| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyanka Kumari, Bechan Sharma, Anup So. (2-Cyclohexyl-1-methylpropyl) cyclohexane isolated from garlic extract exhibits antidepressant-like activity: extraction, docking, drug-like properties, molecular dynamics simulations and MM/GBSA studies. Journal of biomolecular structure & dynamics. 2023-04-25. PMID:37097971. |
using computational analyses, these compounds were screened as potential inhibitors (selective serotonin reuptake inhibitor (ssri)) against serotonin transporter (sert)/leucine receptor (leut). |
2023-04-25 |
2023-08-14 |
Not clear |
| Gao Tu, Binbin Xu, Ding Luo, Jin Liu, Zerong Liu, Gang Chen, Weiwei Xu. Multi-state Model-Based Identification of Cryptic Allosteric Sites on Human Serotonin Transporter. ACS chemical neuroscience. 2023-04-17. PMID:37067527. |
serotonin transporter (sert) plays a fundamental role in taking the synaptic cleft serotonin back to the presynaptic neuron. |
2023-04-17 |
2023-08-14 |
human |
| Gao Tu, Binbin Xu, Ding Luo, Jin Liu, Zerong Liu, Gang Chen, Weiwei Xu. Multi-state Model-Based Identification of Cryptic Allosteric Sites on Human Serotonin Transporter. ACS chemical neuroscience. 2023-04-17. PMID:37067527. |
here, based on the cryo-em structures of ibogaine in complex with sert in distinct conformations, the multiple functional structures of the transporter bound to serotonin, including outward-open (oo |
2023-04-17 |
2023-08-14 |
human |
| Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Da. Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression. Cell communication and signaling : CCS. vol 21. issue 1. 2023-04-12. PMID:37046308. |
herein, we report that serotonin transporter (sert) transports serotonin into colorectal cancer cells, enhancing yes-associated protein (yap) expression and promoting in vitro and in vivo colon cancer cell growth. |
2023-04-12 |
2023-08-14 |
mouse |
| Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Da. Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression. Cell communication and signaling : CCS. vol 21. issue 1. 2023-04-12. PMID:37046308. |
blocking sert with citalopram reversed the serotonin-induced yap expression and cell proliferation, inhibiting serotonin's effects on tumour formation in mice. |
2023-04-12 |
2023-08-14 |
mouse |
| Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Da. Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression. Cell communication and signaling : CCS. vol 21. issue 1. 2023-04-12. PMID:37046308. |
moreover, sert expression was correlated with yap in pathological human colorectal cancer samples and the levels of 5-ht were highly significant in the serum of patients with colorectal cancer. |
2023-04-12 |
2023-08-14 |
mouse |
| Huangfei Yu, Tianyin Qu, Jinlan Yang, Qing Da. Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression. Cell communication and signaling : CCS. vol 21. issue 1. 2023-04-12. PMID:37046308. |
together, our findings suggested that serotonin enters cells via sert to activate rhoa/rock/yap signalling to promote colon cancer carcinogenesis. |
2023-04-12 |
2023-08-14 |
mouse |
| Long-Quan Cheng, Fang-Qi Shu, Min Zhang, Yuan-Zhong Kai, Zheng-Quan Tan. Resveratrol prevents hearing loss and a subregion specific- reduction of serotonin reuptake transporter induced by noise exposure in the central auditory system. Frontiers in neuroscience. vol 17. 2023-04-10. PMID:37034161. |
in the current study, we exposed 2-month-old mice to a narrow band noise at 116 db spl for 6 h or sham exposure, assessed auditory brainstem responses as well as examined the expression of serotonin reuptake transporter (sert) in the cochlear nucleus (cn), inferior colliculus (ic), and primary auditory cortex (au1) using immunohistochemistry. |
2023-04-10 |
2023-08-14 |
mouse |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a Common Thread Linking Different Classes of Antidepressants. Research square. 2023-04-10. PMID:37034599. |
we find that pseudo-equivalent doses of these drugs similarly raise ambient serotonin levels, despite their differing pharmacodynamics because of differences in uptake 1 and 2, rapid sert trafficking and modulation of serotonin by histamine. |
2023-04-10 |
2023-08-14 |
mouse |
| Xuelian Cui, Yongjuan Xu, Haiyan Zhu, Li Wang, Jun Zho. Long noncoding RNA NONHSAG045500 regulates serotonin transporter to ameliorate depressive-like behavior via the cAMP-PKA-CREB signaling pathway in a model of perinatal depression. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 36. issue 1. 2023-03-30. PMID:36997170. |
serotonin transporter [sert]) and produces an antidepressant effect. |
2023-03-30 |
2023-08-14 |
Not clear |
| Xiao-Na Wang, Jiu-Cheng Zhang, Hai-Yuan Zhang, Xiao-Fei Wang, Chun-Xiang Yo. Ectopic expression of MmSERT, a mouse serotonin transporter gene, regulates salt tolerance and ABA sensitivity in apple and Arabidopsis. Plant physiology and biochemistry : PPB. vol 197. 2023-03-20. PMID:36940523. |
sert, a conserved serotonin reuptake transporter in animals, regulates intracellular and extracellular concentrations of 5-ht. |
2023-03-20 |
2023-08-14 |
mouse |
| Shaili Aggarwal, Ole Valente Mortense. Discovery and Development of Monoamine Transporter Ligands. Advances in neurobiology. vol 30. 2023-03-17. PMID:36928847. |
the mat family is comprised of three main members - the dopamine transporter (dat), the norepinephrine transporter (net), and the serotonin transporter (sert). |
2023-03-17 |
2023-08-14 |
Not clear |
| Xiao-Na Zhu, Jie Li, Gao-Lin Qiu, Lin Wang, Chen Lu, Yi-Ge Guo, Ke-Xin Yang, Fang Cai, Tao Xu, Ti-Fei Yuan, Ji H. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron. 2023-03-14. PMID:36917979. |
here, we report that propofol actively and directly binds to the dopamine transporter (dat), but not the serotonin transporter (sert), which contributes to the rapid relief of anhedonia. |
2023-03-14 |
2023-08-14 |
mouse |
| Aaron L Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J Knox, Anand K Muthusamy, Jonathan S Marvin, Charlene H Kim, Stephen N Grant, David P Walton, Bruce N Cohen, Rebekkah Hammar, Loren Looger, Per Artursson, Dennis A Dougherty, Henry A Leste. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-03. PMID:36868853. |
the therapeutic mechanisms that take place before, during, or after ssris bind the serotonin transporter (sert) are poorly understood, partially because no studies exist of the cellular and subcellular pharmacokinetic properties of ssris in living cells. |
2023-03-03 |
2023-08-14 |
Not clear |
| Anjani Uma Rani Wunnava, Sony Priya Kurati, Kilari Eswar Kumar, Murali Krishna Kumar Muthyal. Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1 RSC medicinal chemistry. vol 14. issue 2. 2023-02-27. PMID:36846366. |
the docking simulations also ascertained the selectivity of bm212 towards the serotonin reuptake transporter protein (sert) with a docking score of -6.51 kcal mol |
2023-02-27 |
2023-08-14 |
Not clear |
| John L Krstenansky, John Bacsa, Alexander Zambo. Synthesis, structure, in vitro pharmacology, and in vivo activity of trans-3,4-dichloro-N-[[1-(dimethylamino)-4-phenylcyclohexyl]methyl]-benzamide (AP01; 4-phenyl-AH-7921), a novel mixed μ-/κ-opioid. Journal of forensic sciences. 2023-02-22. PMID:36812253. |
ap01 also had a 4 nm affinity for the serotonin transporter (sert), which is a higher level of potency at this receptor than most other opioids. |
2023-02-22 |
2023-08-14 |
rat |
| Fusun Kili. The nature of the binding between insulin receptor and serotonin transporter in placenta (review). Placenta. vol 133. 2023-02-16. PMID:36796293. |
the interplay between the insulin receptor (ir) and serotonin transporter (sert) allows reciprocal regulation of each other's physiological roles to ensure appropriate responses to specific environmental and developmental signals. |
2023-02-16 |
2023-08-14 |
mouse |
| D E Alcantara-Zapata, N Lucero, N De Gregorio, P Astudillo Cornejo, C Ibarra Villanueva, M J Baltodano-Calle, G F Gonzales, C Beh. Women's mood at high altitude. sexual dimorphism in hypoxic stress modulation by the tryptophan-melatonin axis. Frontiers in physiology. vol 13. 2023-02-03. PMID:36733695. |
sexual dimorphism also evidences the overexpression effects of sert, a 5-ht transporter protein. |
2023-02-03 |
2023-08-14 |
human |
| Haejun Lee, Young Hee Sung, Kyung Hoon Hwan. Additional Role of Midbrain F-18 FP-CIT Uptake on PET in Evaluation of Essential Tremor and Parkinsonism. Current medical imaging. 2023-02-03. PMID:36734891. |
its uptake in other areas of the brain, such as serotonin transporters (sert) in the midbrain or thalamus, is also recognised. |
2023-02-03 |
2023-08-14 |
Not clear |
| Laura C Fox, Jamie L Scholl, Michael J Watt, Gina L Forste. GABA Neuroscience. 2023-02-03. PMID:36736883. |
metabolites of progesterone can allosterically enhance gabaergic signaling, and sex steroids are suggested to regulate the expression of the serotonin transporter (sert). |
2023-02-03 |
2023-08-14 |
Not clear |