| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P Mayer, Leticia Alves da Silva, Sophie M C Skopec, Randy D Blakely, Harald H Sitte, Marko D Mihovilovic, Thomas Stockne. Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors. Nature communications. vol 15. issue 1. 2024-01-09. PMID:38195746. |
the presynaptic serotonin transporter (sert) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter homeostasis. |
2024-01-09 |
2024-01-13 |
human |
| Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P Mayer, Leticia Alves da Silva, Sophie M C Skopec, Randy D Blakely, Harald H Sitte, Marko D Mihovilovic, Thomas Stockne. Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors. Nature communications. vol 15. issue 1. 2024-01-09. PMID:38195746. |
in contrast, illicit drugs of abuse like amphetamines reverse sert directionality, causing serotonin efflux. |
2024-01-09 |
2024-01-13 |
human |
| V Sreeja, Anju Jose, Shashikant Patel, Bindu Menon, K V Athira, Sumana Chakravart. Pharmacogenetics of selective serotonin reuptake inhibitors (SSRI): A serotonin reuptake transporter (SERT)-based approach. Neurochemistry international. 2023-12-29. PMID:38157886. |
pharmacogenetics of selective serotonin reuptake inhibitors (ssri): a serotonin reuptake transporter (sert)-based approach. |
2023-12-29 |
2024-01-05 |
Not clear |
| Lauren R Fitzgerald, Brenda M Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E Blough, Michael H Baumann, William E Fantegross. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Neuropharmacology. 2023-12-28. PMID:38154512. |
automated photobeam analysis was used to evaluate effects of drugs on ambulatory activity in mice, whereas in vitro assays were used to determine activities at transporters for dopamine (dat), norepinephrine (net), and 5-ht (sert) in rat brain synaptosomes. |
2023-12-28 |
2023-12-31 |
mouse |
| Loredana Matiș, Lucia Georgeta Daina, Lavinia Maris, Timea Claudia Ghitea, Daniela Florina Trifan, Ioana Moga, Radu Fodo. Variety of Serotonin Levels in Pediatric Gastrointestinal Disorders. Diagnostics (Basel, Switzerland). vol 13. issue 24. 2023-12-22. PMID:38132259. |
a complex process, which includes dysfunctions in gastrointestinal motility and deregulation of the gene responsible for serotonin reuptake (sert), is implicated in the pathophysiology of irritable bowel syndrome (ibs). |
2023-12-22 |
2023-12-24 |
Not clear |
| Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addari. Mild internet use is associated with epigenetic alterations of key neurotransmission genes in salivary DNA of young university students. Scientific reports. vol 13. issue 1. 2023-12-13. PMID:38092954. |
aim of this study was to investigate epigenetic and genetic regulation of oxytocin receptor (oxtr), dopamine transporter (dat1) and serotonin transporter (sert) genes using dna obtained from saliva samples of young university students: the internet addiction test (iat) was administered to evaluate the potential existence and intensity of ia. |
2023-12-13 |
2023-12-17 |
human |
| Selen Öztürk, Merve Demir, E Arzu Koçkaya, Cagatay Karaaslan, Aysun Kılıç Süloğl. Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine. Reproductive toxicology (Elmsford, N.Y.). 2023-12-03. PMID:38043629. |
intercellular junctions and the localisation of serotonin transporter (sert) proteins were demonstrated by immunofluorescence (if) staining in bewo cells. |
2023-12-03 |
2023-12-10 |
human |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). |
2023-12-01 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. |
2023-12-01 |
2023-12-10 |
mouse |
| Zahra Gholami, Ava Soltani Hekmat, Ali Abasi, Kazem Javanmard. Alamandine injection in the periaqueductal gray and rostral ventromedial medulla attenuates allodynia induced by sciatic nerve ligation in rats. Neuroscience letters. 2023-11-26. PMID:38008350. |
this study aimed to investigate the effects of alamandine (10, 40, and 100 pmol) in a rat model of allodynia induced by sciatic nerve ligation, with a specific focus on examining the involvement of mrgd receptors, nmdar1, and serotonin transporter (sert) in the ventrolateral periaqueductal gray (vlpag) and rostral ventromedial medulla (rvm). |
2023-11-26 |
2023-11-28 |
rat |
| Jamie L Archambault, Cassidy A Delane. A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38002049. |
the lung serves as an important site of 5-ht synthesis, uptake, and metabolism with signaling primarily regulated by tryptophan hydroxylase (tph), the 5-ht transporter (sert), and numerous unique 5-ht receptors. |
2023-11-25 |
2023-11-28 |
Not clear |
| Jamie L Archambault, Cassidy A Delane. A Review of Serotonin in the Developing Lung and Neonatal Pulmonary Hypertension. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38002049. |
the expression of tph, sert, and the 5-ht receptors is developmentally regulated, with alterations resulting in pulmonary vasoconstriction and pulmonary vascular remodeling. |
2023-11-25 |
2023-11-28 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a common thread linking different classes of antidepressants. Cell chemical biology. 2023-11-22. PMID:37992715. |
we find that pseudo-equivalent doses of these drugs similarly raise ambient serotonin levels, despite their differing pharmacodynamics because of differences in uptake 1 and 2, rapid sert trafficking, and modulation of serotonin by histamine. |
2023-11-22 |
2023-11-29 |
mouse |
| Neha Sawant, Sudhir Kshirsagar, P Hemachandra Reddy, Arubala P Redd. Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-06. PMID:37931714. |
we then assessed mrna and protein levels of p-tau, total tau, serotonin related proteins such as tph2, sert, and 5htr1a, synaptic proteins and cytoskeletal structure. |
2023-11-06 |
2023-11-08 |
Not clear |
| Gaël Villanueva-Charbonneau, Stéphane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-Édouard Giguère, Marie-Ève Koué, Édouard Kouass. Serotonin Transporter mRNA Expression Is Reduced in the Peripheral Blood Mononuclear Cells of Subjects with Major Depression but Normal in Fibromyalgia. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891852. |
the objectives of this study were to (i) examine the changes in mrna expression of serotonin transporter (sert) on the surface of peripheral blood mononuclear cells (pbmcs) in fm, mdd, and the fm + mdd subjects compared to healthy controls, and to (ii) evaluate the effect of drug treatment on sert expression. |
2023-10-30 |
2023-11-08 |
human |
| Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Son. Implications for Combination Therapy of Selective Monoamine Reuptake Inhibitors on Dopamine Transporters. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893219. |
monoamine transporters, including dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively), are important therapeutic targets due to their essential roles in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Cary Huang, Andre J van Wijnen, Hee-Jeong Im Sampe. Serotonin transporter (5-HTT, SERT, SLC6A4) and sodium-dependent reuptake inhibitors (SRIs) as modulators of pain behaviors and analgesic responses. The journal of pain. 2023-10-18. PMID:37852405. |
serotonin transporter (5-htt, sert, slc6a4) and sodium-dependent reuptake inhibitors (sris) as modulators of pain behaviors and analgesic responses. |
2023-10-18 |
2023-11-08 |
mouse |
| Cary Huang, Andre J van Wijnen, Hee-Jeong Im Sampe. Serotonin transporter (5-HTT, SERT, SLC6A4) and sodium-dependent reuptake inhibitors (SRIs) as modulators of pain behaviors and analgesic responses. The journal of pain. 2023-10-18. PMID:37852405. |
the serotonin transporter (5-htt, sert, slc6a4) modulates the activity of serotonin via sodium-dependent reuptake. |
2023-10-18 |
2023-11-08 |
mouse |
| Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Białasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Małecka-Wojciesk. The Effect of Serotonin Transmission on Depressive and Insomnia Symptoms in Inflammatory Bowel Diseases. Journal of clinical medicine. vol 12. issue 19. 2023-10-14. PMID:37834999. |
the aim of this study was to investigate the relationship between 5-ht, the serotonin transporter (sert), and the clinical course of the disease with the occurrence of sleep and mood disorders. |
2023-10-14 |
2023-10-15 |
human |
| Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Białasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Małecka-Wojciesk. The Effect of Serotonin Transmission on Depressive and Insomnia Symptoms in Inflammatory Bowel Diseases. Journal of clinical medicine. vol 12. issue 19. 2023-10-14. PMID:37834999. |
serum 5-ht, sert protein expression, and mrna levels were quantified. |
2023-10-14 |
2023-10-15 |
human |