| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuang-Hsin Chiu, Kuo-Hsing Ma, Eagle Yi-Kung Huang, Hsien-Wen Chang, Shao-Ju Weng, Tsung-Hsun Yu, Shiou-Shiow Farn, Yu-Yeh Kuo, Wen-Sheng Huang, Cheng-Yi Cheng, Pao-Luh Tao, Skye Hsin-Hsien Ye. Dextromethorphan moderates reward deficiency associated with central serotonin transporter availability in 3,4-methylenedioxy-methamphetamine-treated animals. Journal of the Chinese Medical Association : JCMA. 2024-04-08. PMID:38587377. |
dextromethorphan (dm), an antitussive drug, decreased morphine- or methamphetamine (ma)-induced reward in rats and may prevent mdma-induced serotonergic deficiency in primates, as indicated by increased serotonin transporter (sert) availability. |
2024-04-08 |
2024-04-10 |
rat |
| Xin Ye, Shubhamoy Ghosh, Bo-Chul Shin, Amit Ganguly, Liesbeth Maggiotto, Jonathan P Jacobs, Sherin U Devaska. Brain serotonin and serotonin transporter expression in male and female postnatal rat offspring in response to perturbed early life dietary exposures. Frontiers in neuroscience. vol 18. 2024-04-05. PMID:38576870. |
serotonin (5-ht) is critical for neurodevelopment and the serotonin transporter (sert) modulates serotonin levels. |
2024-04-05 |
2024-04-07 |
rat |
| Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinnin. 5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504103. |
we demonstrate the applicability of the method for the study of a neuronal, high-affinity, low-capacity serotonin transporter (sert) as well as an extraneuronal low-affinity, high-capacity organic cation transporter and mutants thereof. |
2024-03-20 |
2024-03-23 |
Not clear |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
in addition, serotonin transporter (sert) levels were measured in the synaptosome of the dorsal striatum, and serotonin (5-ht) levels were measured in the dorsal striatum of acute mexedreone (50 mg/kg)-treated mice. |
2024-03-02 |
2024-03-06 |
mouse |
| Kyung Oh Jeon, Oc-Hee Kim, Soo Yeon Seo, Jaesuk Yun, Choon-Gon Jang, Ri-Na Lim, Tae Wan Kim, Chae Ha Yang, Seong Shoon Yoon, Eun Young Jan. The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats. European journal of pharmacology. 2024-03-02. PMID:38431243. |
acute mexedrone significantly increased c-fos expression in the dorsal striatum and decreased sert levels in the synaptosome of the dorsal striatum of mice, resulting in elevation of 5-ht levels. |
2024-03-02 |
2024-03-06 |
mouse |
| Mary Beth Bauer, Kevin P M Curri. Serotonin and the serotonin transporter in the adrenal gland. Vitamins and hormones. vol 124. 2024-02-28. PMID:38408804. |
in this article we review serotonin (5-ht) and the serotonin transporter (sert; slc6a4) in the adrenal gland. |
2024-02-28 |
2024-03-01 |
Not clear |
| Michael Tea, Yihang Kevin Pan, Joshua G R Lister, Steve F Perry, Kathleen M Gilmou. Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2024-02-28. PMID:38416162. |
zebrafish (danio rerio) are unusual in having two paralogues of the serotonin re-uptake transporter (sert), slc6a4a (serta) and slc6a4b (sertb), the transporter that serves in serotonin re-uptake from a synapse into the pre-synaptic cell or in serotonin uptake from the extracellular milieu into cells in the peripheral tissues. |
2024-02-28 |
2024-03-01 |
zebrafish |
| Samantha Alvarez-Herrera, Mauricio Rosel Vales, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Yvonne Flores-Medina, José Luis Maldonado-García, Ricardo Saracco-Alvarez, Raúl Escamilla, Lenin Pavó. Risperidone Decreases Expression of Serotonin Receptor-2A (5-HT2A) and Serotonin Transporter (SERT) but Not Dopamine Receptors and Dopamine Transporter (DAT) in PBMCs from Patients with Schizophrenia. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399382. |
risperidone decreases expression of serotonin receptor-2a (5-ht2a) and serotonin transporter (sert) but not dopamine receptors and dopamine transporter (dat) in pbmcs from patients with schizophrenia. |
2024-02-24 |
2024-02-26 |
Not clear |
| Fusun Kili. Serotonin Signaling and the Hyperpermeable Endothelial Barrier in Sepsis: Clues to a Molecular Mechanism. Journal of community medicine & public health. vol 7. issue 4. 2024-02-19. PMID:38371611. |
the actions of 5-ht are mediated by different types of receptors and terminated via an uptake mechanism of a 5-ht transporter (sert) on the platelet and endothelial cell. |
2024-02-19 |
2024-02-21 |
Not clear |
| Dongxue Yang, Eric Gouau. Illumination of serotonin transporter mechanism and role of the allosteric site. Science advances. vol 7. issue 49. 2024-02-14. PMID:34851672. |
the serotonin transporter (sert) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders. |
2024-02-14 |
2024-02-16 |
Not clear |
| Dongxue Yang, Eric Gouau. Illumination of serotonin transporter mechanism and role of the allosteric site. Science advances. vol 7. issue 49. 2024-02-14. PMID:34851672. |
together with elucidation of multiple apo state conformations, we provide previously unseen structural understanding of allosteric modulation, demonstrating how sert binds serotonin from synaptic volumes and promotes unbinding into the presynaptic neurons. |
2024-02-14 |
2024-02-16 |
Not clear |
| Jia-Ya Zheng, Xue-Xin Li, Xiao Liu, Chen-Chen Zhang, Ya-Xin Sun, Yu-Nu Ma, Hong-Li Wang, Yun-Ai Su, Tian-Mei Si, Ji-Tao L. Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. Pharmacology, biochemistry, and behavior. 2024-02-09. PMID:38336220. |
at the molecular level, we largely replicated the es effects, such as reduced serotonin transporter (sert) expression in the amygdala and increased norepinephrine transporter (net) expression in the medial prefrontal cortex (mpfc) and hippocampus. |
2024-02-09 |
2024-02-12 |
mouse |
| Fusun Kilic, Imane Moutkine, Luc Maroteau. Association with serotonin transporter enables the phosphorylation of insulin receptor in placenta. Current topics in biochemical research. vol 20. 2024-02-08. PMID:38327526. |
interestingly the cellular distribution of the serotonin transporter (sert), which utilizes the insulin signaling for posttranslational modification, shows tissue-type-dependent variation: sert function is impaired in gdm-associated placenta, but not in platelets. |
2024-02-08 |
2024-02-10 |
Not clear |
| Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockne. Free energy profile of the substrate-induced occlusion of the human serotonin transporter. Journal of neurochemistry. 2024-02-05. PMID:38316690. |
the serotonin transporter (sert) is a member of the solute carrier 6 (slc6) family and is responsible for maintaining the appropriate level of serotonin in the brain. |
2024-02-05 |
2024-02-09 |
human |
| Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockne. Free energy profile of the substrate-induced occlusion of the human serotonin transporter. Journal of neurochemistry. 2024-02-05. PMID:38316690. |
here, we constructed markov state models (msms) from extensive unbiased molecular dynamics simulations to quantify the free energy profile of serotonin (5ht) triggered sert occlusion and explored the driving forces of the mechanism of occlusion. |
2024-02-05 |
2024-02-09 |
human |
| Leticia Alves da Silva, Erika Lazzarin, Ralph Gradisch, Amy Clarke, Thomas Stockne. Free energy profile of the substrate-induced occlusion of the human serotonin transporter. Journal of neurochemistry. 2024-02-05. PMID:38316690. |
some interactions become repulsive upon full occlusion, suggesting that sert creates pressure on 5ht to promote its movement towards the cytosol. |
2024-02-05 |
2024-02-09 |
human |
| Paula A Gajeswski-Kurdziel, Allison E Walsh, Randy D Blakel. Functional and pathological consequences of being fast on the uptake: Protein kinase G and p38α MAPK regulation of serotonin transporters. Current research in physiology. vol 7. 2024-02-01. PMID:38298474. |
the presynaptic, 5-ht transporter (sert) has a well-established role in regulating 5-ht signaling and is a target of widely prescribed psychotherapeutics, the 5-ht selective reuptake inhibitors (ssris). |
2024-02-01 |
2024-02-03 |
Not clear |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
monoamine content, serotonin (5-ht) release, 5-ht uptake, 5-ht transporter (sert) protein levels, and behaviors were investigated in mice subjected to chronic social defeat stress and in mice with knockdown of slc6a4, in 5-htergic neurons projecting to the prefrontal cortex (pfc). |
2024-02-01 |
2024-02-04 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
increased turnover, increased extracellular basal levels, decreased release and decreased uptake of 5-ht, and decreased sert protein levels were observed in the pfc of the stressed mice. |
2024-02-01 |
2024-02-04 |
mouse |
| Mariko Nakamura, Akira Yoshimi, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Tomoya Miyauchi, Kunihiro Iwamoto, Mikiko Ito, Aiji Sato-Boku, Akihiro Mouri, Toshitaka Nabeshima, Norio Ozaki, Yukihiro Nod. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein. Pain. 2024-01-16. PMID:38227563. |
the aim of this study was to confirm effects of dlx on pain and depressive symptoms, and to associate with their effectiveness in platelet serotonin transporter (sert) expression, which is a target molecule of dlx and plasma serotonin concentration in cop patients with depressive symptoms. |
2024-01-16 |
2024-01-19 |
Not clear |